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Table 2 Clinical characteristics of Māori gastric cancer patients with pathogenic germline CDH1 mutations

From: Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand Māori

Identifier Agea Gender Nucleotid changeb Protein changeb Subtype Extent Grade Site
Y240 24 Female c.190C>T p.Gln64* Diffuse Local NOS NOS
Y382 29 Male c.190C>T p.Gln64* Diffuse Local NOS Proximal
Y704 48 Female c.190C>T p.Gln64* Diffuse Local NOS NOS
Y647 61 Female c.190C>T p.Gln64* Diffuse Local NOS Distal
Y649 20 Female c.1792C>T p.Arg598* Diffuse Local NOS NOS
Y579 23 Female c.1792C>T p.Arg598* Diffuse Local NOS NOS
Y709 24 Male c.1792C>T p.Arg598* Diffuse Local Poorly differentiated Proximal
Y255 29 Female c.1792C>T p.Arg598* Diffuse Local NOS Proximal
Y616 38 Female c.2195G>A p.Arg732Gln Diffuse Metastatic spread Poorly differentiated NOS
Y435 31 Female c.2287G>T p.Glu763* Diffuse Local Poorly differentiated Proximal
Y670 39 Female c.2287G>T p.Glu763* Diffuse Metastatic spread NOS NOS
Y706 41 Male c.2287G>T p.Glu763* Diffuse Local NOS NOS
Y335 50 Male c.2287G>T p.Glu763* Diffuse Local NOS NOS
Y638 17 Male c.2381_2386insC p.Arg796fs Diffuse Local NOS NOS
Y425 20 Male c.2381_2386insC p.Arg796fs Diffuse Local NOS NOS
Y666 26 Female c.2381_2386insC p.Arg796fs Diffuse Local NOS NOS
Y386 44 Male c.2381_2386insC p.Arg796fs Diffuse Local NOS NOS
  1. NOS not otherwise specified
  2. aAge at time of diagnosis
  3. bVariant positions are reported in reference to NCBI RefSeq NM_004360.3 (mRNA) and NP_004351.1 (protein)
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