References
National cancer institute: SEER cancer Stat Facts: Colon and Rectum Cancer. https://seer.cancer.gov/statfacts/html/colorect.html
Shia J (2015) Evolving approach and clinical significance of detecting DNA mismatch repair deficiency in colorectal carcinoma. Semin Diagn Pathol 32:352–361
Salipante SJ, Scroggins SM, Hampel HL, Turner EH, Pritchard CC (2014) Microsatellite instability detection by next generation sequencing. Clin Chem 60:1192–1199
Huang MN, McPherson JR, Cutcutache I, Teh BT, Tan P, Rozen SG (2015) MSIseq: software for assessing microsatellite instability from catalogs of somatic mutations. Sci Rep 5:13321
Niu B, Ye K, Zhang Q et al (2014) MSIsensor: microsatellite instability detection using paired tumor-normal sequence data. Bioinformatics 30:1015–1016
Cheng DT, Mitchell TN, Zehir A et al (2015) Memorial Sloan Kettering-integrated mutation profiling of actionable cancer targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology. J Mol Diagn 17:251–264
Stadler ZK, Battaglin F, Middha S et al (2016) Reliable detection of mismatch repair deficiency in colorectal cancers using mutational load in next-generation sequencing panels. J Clin Oncol 34:2141–2147
Furlow B (2016) Clinton and Trump: competing visions for the Affordable Care Act and US health care. Lancet Oncol 17:1197–1198
Berends MJ, Wu Y, Sijmons RH et al (2002) Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant. Am J Hum Genet 70:26–37
Goel A, Nagasaka T, Hamelin R, Boland CR (2010) An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers. PLoS ONE 5:e9393
Shia J (2008) Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry. J Mol Diagn 10:293–300
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Hechtman, J.F., Middha, S., Stadler, Z.K. et al. Universal screening for microsatellite instability in colorectal cancer in the clinical genomics era: new recommendations, methods, and considerations. Familial Cancer 16, 525–529 (2017). https://doi.org/10.1007/s10689-017-9993-x
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DOI: https://doi.org/10.1007/s10689-017-9993-x