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Familial Cancer

, Volume 16, Issue 3, pp 339–349 | Cite as

The association between prognosis of breast cancer and first-degree family history of breast or ovarian cancer: a systematic review and meta-analysis

  • Jun-Long Song
  • Chuang Chen
  • Jing-Ping Yuan
  • Sheng-Rong SunEmail author
REVIEW
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Abstract

Whether a positive family history of breast cancer or ovarian cancer (FHBOC) would affect the prognosis of breast cancer is still up for debate and further study. This meta-analysis was performed to clarify this issue. We reviewed two databases (PubMed and CNKI) for research articles published at any time from the inception of these databases to April 1, 2016 for articles detecting the impact of FHBOC on the prognosis of breast cancer. A meta-analysis was conducted to generated combined hazard ratios (HR) with 95% confidence intervals (CI) for overall survival (OS) and breast cancer-specific survival (BCSS). Eighteen studies were included in our qualitative analysis, with 15 studies ultimately part of the quantitative analysis. The pooled results demonstrated that a positive FHBOC was associated with better OS (0.89, 95% CI 0.83–0.95) and BCSS (0.90, 95% CI 0.82–0.99). In subgroup analyses, several subgroups (maximally adjusted studies, population based studies, high quality studies, family history of breast cancer, studies from Europe, studies from Asia, 1 affected relative, or tumor size > 2 cm), a positive first-degree FHBOC was associated with better prognosis of breast cancer. Notably, for those patients who underwent breast-conserving surgery, first-degree FHBOC was not a risk factor for OS (HR 1.08, 95% CI 0.53–2.21). Our meta-analysis demonstrated that a first-degree FHBOC was associated with better OS and BCSS in patients with breast cancer. These findings support that clinical management should not differ between women with and without FHBOC.

Keywords

Breast cancer Family history Prognosis Systemic review 

Notes

Acknowledgements

This research was supported by the grants from the National Science Foundation of China (No. 81471781 and 81230031), the National Key Scientific Instrument and Equipment Development Project (20133655893), the Natural Science Foundation of Hubei Province, China (2014CKB509 and 2013CFB374).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Jun-Long Song
    • 1
  • Chuang Chen
    • 1
  • Jing-Ping Yuan
    • 2
  • Sheng-Rong Sun
    • 1
    Email author
  1. 1.Department of Breast and Thyroid SurgeryRenmin Hospital of Wuhan UniversityWuhanPeople’s Republic of China
  2. 2.Department of PathologyRenmin Hospital of Wuhan UniversityWuhanPeople’s Republic of China

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