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Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical squamous cell carcinoma

Abstract

The programmed cell death 6 (PDCD6), discovered as a proapoptotic calcium-binding protein, has recently been found dysregulated in tumors of various origin and contributed to cancer cell viability. The aim of this study was to determine whether SNPs in PDCD6 are associated with cervical squamous cell carcinoma (CSCC). Polymerase chain reaction-restriction fragment length polymorphism method was used to genotype two tag SNPs (rs3756712 and rs4957014) of PDCD6 in 328 CSCC patients and 541 controls. Significantly increased CSCC risks were found to be associated with T allele of rs3756712 and G allele of rs4957014 (P = 0.017, OR = 1.320, and P = 0.007, OR = 1.321, respectively). CSCC risks were associated with these two SNPs in different genetic model (P = 0.04, OR = 1.78 for rs3756712 in a recessive model, and P = 0.006, OR = 2.01 for rs4957014 in a codominant model, respectively). Results of stratified analyses revealed that rs4957014 is associated with parametrial invasion of CSCC (P = 0.044, OR = 1.414). Our results suggest that these two tag SNPs of PDCD6 are associated with CSCC, indicating that PDCD6 may play an important role in the pathogenesis of CSCC.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81172440, No. 81272821, No. 81172494 and No. 30901596); the Applied Basic Research Programs of Science and Technology Commission Foundation of Sichuan Province (No. 2013JY0008 and No. 2013JY0013); and Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT0935).

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The authors declare that they have no conflict of interest.

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Correspondence to Lin Zhang.

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Bin Zhou and Peng Bai have contributed equally to this work.

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Cite this article

Zhou, B., Bai, P., Xue, H. et al. Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical squamous cell carcinoma. Familial Cancer 14, 1–8 (2015). https://doi.org/10.1007/s10689-014-9767-7

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  • DOI: https://doi.org/10.1007/s10689-014-9767-7

Keywords

  • Cervical squamous cell carcinoma (CSCC)
  • PDCD6
  • SNP
  • Risk