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Mammographic surveillance in women aged 35–39 at enhanced familial risk of breast cancer (FH02)

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Abstract

Although there have been encouraging recent studies showing a potential benefit from annual mammography in women aged 40–49 years of age with an elevated breast cancer risk due to family history there is little evidence of efficacy in women aged <40 years of age. A prospective study (FH02) has been developed to assess the efficacy of mammography screening in women aged 35–39 years of age with a lifetime breast cancer risk of ≥17 % who are not receiving MRI screening. Retrospective analyses from five centres with robust recall systems identified 47 breast cancers (n = 12 in situ) with an interval cancer rate of 15/47 (32 %). Invasive tumour size, lymph node status and current vital status were all significantly better than in two control groups of unscreened women (including those with a family history) recruited to the POSH study. Further evaluation of the prospective arm of FH02 is required to assess the potential added value of digital mammography and the cancer incidence rates in moderate and high risk women in order to inform cost effectiveness analyses.

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Acknowledgments

We thank Breast Cancer Campaign for funding the FH02 study. Prof Gareth Evans is an NIHR senior investigator.

Conflict of interest

The authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Trust, Wythenshawe, Manchester, M23 9LT, UK

    D. G. Evans, L. Roberts & A. Howell

  2. Genetic Medicine, Manchester Academic Health Science Centre, Central Manchester Foundation Trust, St. Mary’s Hospital, The University of Manchester, Oxford Road, Manchester, M13 9WL, UK

    D. G. Evans

  3. Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Withington, Manchester, M20 4BX, UK

    D. G. Evans & A. Howell

  4. Breast Screening Unit, Nightingale Centre, University Hospital of South Manchester NHS Trust, Wythenshawe, Manchester, M23 9LT, UK

    M. Wilson

  5. Breast Test Wales, 18 Cathedral Road, Cardiff, CF11 9LJ, UK

    S. Thomas, J. Caunt & R. Fox

  6. Breast Unit, Royal Derby Hospital, Derby, DE22 3NE, UK

    D. M. Sibbering

  7. Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine’ Charterhouse Square, London, EC1M 6BQ, UK

    S. Moss & S. Duffy

  8. Cambridge Breast Unit and NIHR Cambridge Biomedical Research Unit, Cambridge University Hospitals NHS Foundation Trust, Box 97, Hills Road, Cambridge, CB2 0QQ, UK

    M. G. Wallis

  9. MP131, Southampton General Hospital, Tremona Road, Southampton, Hants, SO16 6YD, UK

    D. M. Eccles

Authors
  1. D. G. Evans
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  2. S. Thomas
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  3. J. Caunt
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  4. L. Roberts
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  5. A. Howell
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  6. M. Wilson
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  7. R. Fox
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  8. D. M. Sibbering
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  9. S. Moss
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  10. M. G. Wallis
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  11. D. M. Eccles
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  12. S. Duffy
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Consortia

FH02 study group

Corresponding author

Correspondence to D. G. Evans.

Additional information

Please see the “Appendix” section for FH02 study group authors.

Appendix

Appendix

FH02 study group authors

Airedale NHS Foundation Trust

Eleanor Waldron

 

Ardmillan Screening Centre, Edinburgh

Dr Lesley Smart

Lynda Luke

Birmingham

Mrs Simerjit Rai

 

Bradford

Dr Richard Linforth

 

BTW Cardiff

Guy Stevens

Jane Evans

BTW Llandudno

Guy Stevens

Jane Evans

BTW Singleton

Guy Stevens

Jane Evans

Burton, Queen’s Hospital

Dr Nick Luft

None

Chester

Ms Hollie Devlin

 

Craigavon Area Hospital, Northern Ireland

Dr Cathy Farnon

Ruth Hall

Derby

Wendy Chorley

Diana Mayor

Great Ormond Street/Barts

Dr Vian Salih

 

Grantham District Hospital

Mr N Potdar

Mr A Modi

Hope Hospital, Salford

Joy Hunter

 

Kettering

Mr Mohammed Rashed

 

Leeds

Mr Philip Turton

Mrs Sue Hartup

Leicester

Dr Julian Barwell

 

Leighton Hospital, Crewe

Tracey Hale

 

Newcastle

Dr Alex Henderson

Irene Jobson

Northwick Park Hospital

Mr William Teh

 

Nottingham

Mr R.D Macmillan

 

Pilgrim Hospital Boston Lincs

Mr N Potdar

Mrs Ambika Anand

Portsmouth

Carmel Sheppard

 

Royal Devon & Exeter

Di Cameron

Mary Davies

Royal Liverpool University Hospital

Sue Holcombe

Laura Francis

Royal Marsden Hospital, London

Mr Gerald Gui

Dr Janet Self

Royal United Hospital, Bath

Dr Diana Dalgliesh

Katherine Knight

Southend

Mr Neil Rothnie

 

Truro

Dr D Christensen

 

Ulster

Dr Janet Newell

Ethna McFerran

University Hospital of South Manchester

Rosemary Greenhalgh

Jenny Affen

University Hospitals Coventry & Warwickshire NHS Trust

Celia Lewis

 

Whiston Hospital, Prescot, Merseyside

Riccardo Audisio

 

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Evans, D.G., Thomas, S., Caunt, J. et al. Mammographic surveillance in women aged 35–39 at enhanced familial risk of breast cancer (FH02). Familial Cancer 13, 13–21 (2014). https://doi.org/10.1007/s10689-013-9661-8

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