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Microsatellite instability analysis in uterine cavity washings as a screening tool for endometrial cancer in Lynch syndrome

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Abstract

Although patients with Lynch syndrome (LS) are at high risk of endometrial cancer, gynecologic screening has been poorly investigated and diagnostic value of current screening tests remains unclear. Microsatellite instability (MSI) phenotype is found in more than 90% of endometrial cancers developed in LS patients. Here we report the first two cases of unstable endometrial tumors with detection of MSI in uterine cavity washings cells. This new technique may be a promising screening tool in LS.

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Abbreviations

HNPCC:

Hereditary non polyposis colorectal cancer

LS:

Lynch syndrome

MMR:

Mismatch repair

MSI:

Microsatellite instability

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Authors and Affiliations

  1. Université Paris Descartes, Paris, France

    Julie Bouquier, Hélène Blons, Céline Narjoz, Fabrice Lécuru, Pierre Laurent-Puig & Anne-Sophie Bats

  2. Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Chirurgie Gynécologique et Cancérologique, 20, Rue Leblanc, 75015, Paris, France

    Julie Bouquier, Fabrice Lécuru & Anne-Sophie Bats

  3. Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Paris, France

    Hélène Blons & Céline Narjoz

  4. INSERM UMR S 747, Paris, France

    Fabrice Lécuru & Anne-Sophie Bats

  5. Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, Paris, France

    Pierre Laurent-Puig

  6. INSERM UMR S775, Paris, France

    Pierre Laurent-Puig

Authors
  1. Julie Bouquier
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  2. Hélène Blons
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  3. Céline Narjoz
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  4. Fabrice Lécuru
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  5. Pierre Laurent-Puig
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  6. Anne-Sophie Bats
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Corresponding author

Correspondence to Anne-Sophie Bats.

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Bouquier, J., Blons, H., Narjoz, C. et al. Microsatellite instability analysis in uterine cavity washings as a screening tool for endometrial cancer in Lynch syndrome. Familial Cancer 10, 655–657 (2011). https://doi.org/10.1007/s10689-011-9470-x

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  • DOI: https://doi.org/10.1007/s10689-011-9470-x

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