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CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia

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Abstract

A truncating mutation (1100delC) in the cell cycle checkpoint kinase-2 gene, CHEK2, has been identified as a risk factor for familial and sporadic breast cancer in some Northern and Western European populations. However, the prevalence of CHEK2*1100delC in breast cancer appears to be population dependent. We analysed the prevalence of CHEK2*1100delC in 668 breast cancer cases, of which 542 were invasive breast cancers, from a hospital-based cohort of breast cancer patients from Kuala Lumpur, Malaysia. The variant was not found in any patients in this cohort, suggesting that CHEK2*1100delC is rare in our population, and unlikely to contribute significantly to risk to breast cancer among the Malay, Chinese and Indian ethnic groups in Malaysia. This suggests that screening for this allele should not be routinely conducted in Malaysia.

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Acknowledgments

Grant support: E-Science fund from Ministry of Science, Technology and Innovation, Malaysia (02-04-03-SF0002)

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Authors and Affiliations

  1. Cancer Research Initiatives Foundation, 2nd Floor Outpatient Centre, Sime Darby Medical Centre, 47500, Subang Jaya, Malaysia

    Eswary Thirthagiri, Leng San Cheong & Soo-Hwang Teo

  2. Department of General and Breast Surgery, University Malaya Medical Centre, 50603, Kuala Lumpur, Malaysia

    Cheng Har Yip

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  1. Eswary Thirthagiri
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  2. Leng San Cheong
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  4. Soo-Hwang Teo
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Correspondence to Soo-Hwang Teo.

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Thirthagiri, E., Cheong, L.S., Yip, C.H. et al. CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia. Familial Cancer 8, 355–358 (2009). https://doi.org/10.1007/s10689-009-9244-x

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  • DOI: https://doi.org/10.1007/s10689-009-9244-x

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