Abstract
Muir-Torre syndrome (MTS) is a rare cancer-predisposing syndrome that is autosomal dominantly inherited and characterized by the development of sebaceous skin lesions (adenomas, epitheliomas, basaliomas and carcinomas). These lesions are typically associated with tumors that belong to the spectrum of hereditary nonpolyposis colorectal cancer (HNPCC) (i.e. tumors of the colorectum, endometrium, stomach or ovary). Biliary malignancy in association with MTS has only rarely been reported. We report a case of Muir-Torre syndrome associated with intrahepatic cholangiocarcinoma, a location not previously described, and associated with a novel missense mutation of the MSH2 gene (c.2026T > C), predicted to disrupt the function of the gene.
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Abbreviations
- CEA:
-
carcino embryonic antigen
- HNPCC:
-
hereditary non polyposis colon cancer
- MTS:
-
Muir-Torre syndrome
- MRI:
-
magnetic resonance imaging
- MSI:
-
microsatellite instability
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Vernez, M., Hutter, P., Monnerat, C. et al. A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene. Familial Cancer 6, 141–145 (2007). https://doi.org/10.1007/s10689-006-9105-9
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DOI: https://doi.org/10.1007/s10689-006-9105-9