Skip to main content

Advertisement

SpringerLink
Log in

The Challenge of Developing Evidence-Based Genetics Health Care in Practice

  • Published:
Familial Cancer Aims and scope Submit manuscript

Abstract

Evidence-based genetics health care is the conscientious use of current best evidence in decision-making at the clinical, administrative and policy-making levels. As knowledge generated from genomics research is integrated into medical care, the needs for appropriate evidence become more complex. The challenges to evidence-based care include: a lack of policy-relevant evidence in the domains of basic, clinical and health services research (including ethical, legal and social issues); difficulties in translating knowledge into appropriate decisions and actions, particularly in relation to the capacity of audiences to interpret evidence; and competing perspectives on the nature of evidence in genetics and genomics. In meeting these challenges, lessons will be learnt which are likely to be relevant to emerging biotechnologies and health care development more generally.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. DL Sackett WMC Rosenberg JAM, Gray et al. (1996) ArticleTitleEvidence based medicine: What it is and what it isn’t BMJ 312 71–2 Occurrence Handle1:STN:280:BymC2c7ptFE%3D Occurrence Handle8555924

    CAS  PubMed  Google Scholar 

  2. First Annual Nordic Workshop on how to critically appraise and use evidence in decisions about healthcare. National Institute of Public Health, Oslo, Norway, 1996.

  3. SR Tunis DB Stryer CM Clancy (2003) ArticleTitlePractical clinical trials. Increasing the value of clinical research for decision making in clinical and health policy JAMA 290 1624–32 Occurrence Handle10.1001/jama.290.12.1624 Occurrence Handle1:CAS:528:DC%2BD3sXnvVCis7c%3D Occurrence Handle14506122

    Article  CAS  PubMed  Google Scholar 

  4. J Grimshaw B Wilson M Campbell et al. (2001) Epidemiological methods N Fulop P Allen A Clarke N Black (Eds) Studying the Organization, Delivery of Health Services. Research Methods Routledge UK 56–72

    Google Scholar 

  5. MJ Khoury (2003) ArticleTitleGenetics and genomics in practice: The continuum from genetic disease to genetic information in health and disease Genet Med 5 261–8 Occurrence Handle12865755

    PubMed  Google Scholar 

  6. BJ Wilson JM Grimshaw NE Haites (2004) Using human genome epidemiologic evidence in developing genetics services: The UK experience MJ Khoury J Little W Burke (Eds) Human Genome Epidemiology: Scientific Basis for Using Genetic Information to Improve Health and Prevent Disease. Oxford University Press New York 283–301

    Google Scholar 

  7. PA Coventry JV Pickstone (1999) ArticleTitleFrom what and why did genetics emerge as a medical specialism in the 1970s in the UK? A case-history of research, policy and services in the Manchester region of the NHS Soc Sci Med 49 1227–38 Occurrence Handle10.1016/S0277-9536(99)00162-8 Occurrence Handle1:STN:280:DyaK1MvivFOmsw%3D%3D Occurrence Handle10501643

    Article  CAS  PubMed  Google Scholar 

  8. D Wonderling P Hopwood A Cull et al. (2001) ArticleTitleA descriptive study of UK cancer genetics services: An emerging clinical response to the new genetics Br J Cancer 85 166–70 Occurrence Handle10.1054/bjoc.2001.1893 Occurrence Handle1:STN:280:DC%2BD3MvhtF2qtA%3D%3D Occurrence Handle11461071

    Article  CAS  PubMed  Google Scholar 

  9. McIntosh A, Shaw C, Evans G et al. Clinical guidelines and evidence review for the classification and care of women at risk of familial breast cancer. London: National Collaborating Centre for Primary Care/University of Sheffield, 2004.

  10. F Eisinger B Bressac D Castaigne et al. (2004) ArticleTitleIdentification et prise en charge des prédispositions héréditaires aux cancers du sein et de l’ovaire (mise à jour 2004) Bull Cancer 91 219–37 Occurrence Handle15171047

    PubMed  Google Scholar 

  11. JPA Ioannidis (2003) ArticleTitleGenetic associations: False or true? Trends Mol Med 9 135–8 Occurrence Handle10.1016/S1471-4914(03)00030-3 Occurrence Handle12727138

    Article  PubMed  Google Scholar 

  12. MR McClain GE Palomaki KL Nathanson JE Haddow (2005) ArticleTitleAdjusting the estimated proportion of breast cancer cases associated with BRCA1 and BRCA2 mutations: Public health implications Genet Med 7 28–33 Occurrence Handle1:CAS:528:DC%2BD2MXkvFWgug%3D%3D Occurrence Handle15654225

    CAS  PubMed  Google Scholar 

  13. MJ Khoury R Millikan J Little M Gwinn (2004) ArticleTitleThe emergence of epidemiology in the genomics age Int J Epidemiol 33 936–44 Occurrence Handle10.1093/ije/dyh278 Occurrence Handle15319400

    Article  PubMed  Google Scholar 

  14. AL Cochrane (1989) Effectiveness and Efficiency: Random Reflections on the Health Service BMJ Publishing Group London

    Google Scholar 

  15. D Schwartz J Lellouch (1967) ArticleTitleExplanatory and pragmatic attitudes in therapeutic trials J Chron Dis 20 637–48 Occurrence Handle10.1016/0021-9681(67)90041-0 Occurrence Handle1:STN:280:CCeD3c%2Fls1Q%3D Occurrence Handle4860352

    Article  CAS  PubMed  Google Scholar 

  16. D Braithwaite J Emery F Walter et al. (2004) ArticleTitlePsychological impact of genetic counseling for familial cancer: A systematic review and meta-analysis J Natl Cancer Inst 96 122–33 Occurrence Handle14734702

    PubMed  Google Scholar 

  17. M Giacomini F Miller G Browman (2003) ArticleTitleConfronting the “gray zones” of technology assessment: Evaluating genetic testing services for public insurance coverage in Canada Int J Technol Assess Health Care 19 301–16 Occurrence Handle12862188

    PubMed  Google Scholar 

  18. J. Coast (2004) ArticleTitleIs economic evaluation in touch with society’s health values? BMJ 328 1233–6

    Google Scholar 

  19. Lomas J. Improving research dissemination and uptake in the health sector: Beyond the sound of one hand clapping. Hamilton, Ontario, Canada: McMaster University Centre for Health Economics and Policy Analysis. Policy Commentary C97-1, 1997: 1–45.

  20. The 1998 Canadian Biotechnology Strategy: An ongoing renewal process. Ottawa: Industry Canada, 1998.

  21. JM Birdsell J Atkinson-Grosjean R Landry (2002) Knowledge Translation in Two New Programs: Achieving ‘The Pasteur Effect’ Canadian Institutes of Health Research Ottawa

    Google Scholar 

  22. P Lehoux S Blume (2000) ArticleTitleTechnology assessment and the sociopolitics of health technologies J Health Polit Policy Law 25 1083–120 Occurrence Handle1:STN:280:DC%2BD3M%2Fpslynuw%3D%3D Occurrence Handle11142053

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Epidemiology & Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada

    Brenda J. Wilson

Authors
  1. Brenda J. Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brenda J. Wilson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wilson, B.J. The Challenge of Developing Evidence-Based Genetics Health Care in Practice. Familial Cancer 5, 55–59 (2006). https://doi.org/10.1007/s10689-005-2576-2

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10689-005-2576-2

Keywords

Search

Navigation