The inheritance of chemical phenotype in Cannabis sativa L. (II): Cannabigerol predominant plants
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This paper aims to clarify the genetic mechanism that is responsible for the accumulation of cannabigerol (CBG) in certain phenotypes of Cannabis sativa L. CBG is the direct precursor of the cannabinoids CBD, THC and CBC. Plants strongly predominant in CBG have been found in different fibre hemp accessions. Inbred offspring derived from one such individual were crossed with true breeding THC predominant- and CBD predominant plants, respectively. The segregations in the cross progenies indicate that CBG accumulation is due to the homozygous presence of a minimally functional allele, tentatively called B0, at the single locus B that normally controls the conversion of CBG into THC (allele BT) and/or CBD (allele BD). The fact that CBG accumulating plants have so far been found in European fibre hemp populations that are generally composed of BD/BD plants, and the observation that the here investigated B0 allele possesses a residual ability to convert small amounts of CBG into CBD, make it plausible that this B0 is a mutation of normally functional BD. Therefore, B0 is considered as a member of the BD allelic series encoding a CBD synthase isoform with greatly weakened substrate affinity and/or catalytic capacity.
Keywordscannabigerol cannabinoids Cannabis chemotype inheritance
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- Gaoni, Y. & R. Mechoulam, 1964b. The structure and synthesis of cannabigerol a new hashish constituent. Proc Chem Soc, March: 82.Google Scholar
- Gaoni, Y. & R. Mechoulam, 1966. Cannabichromene, a new active principle in hashish. Chem Commun 1: 20–21.Google Scholar
- Hillig, K. & E.P.M. de Meijer, 2004. Letter to the editor ‘On Cannabis’. Econ Bot 58: 328.Google Scholar
- Hillig, K.W. & P.G. Mahlberg, 2004. A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae). Am J Bot 91: 966–975.Google Scholar
- de Meijer, E.P.M., 2004. The breeding of Cannabis cultivars for pharmaceutical end-uses. In: G.W. Guy, B.A. Whittle & P.J. Robson (Eds.), The medicinal uses of Cannabis and cannabinoids, pp. 55–69. Pharmaceutical Press, London.Google Scholar
- Small, E. & D. Marcus, 2003. Tetrahydrocannabinol levels in hemp (Cannabis sativa) germplasm resources. Econ Bot 57: 545–558.Google Scholar
- Virovets, V.G., 1996. Selection for non-psychoactive hemp varieties (Cannabis sativa L.) in the CIS (former USSR). J Int Hemp Assoc 3: 13–15.Google Scholar
- Vree, T.B., D.D. Breimer, C.A.M. van Ginneken & J.M. van Rossum, 1971. Identification of the methyl and propyl homologues of CBD, THC and CBN in hashish by a new method of combined gas chromatography-mass spectrometry. Acta Pharm Suedica 8: 683–684.Google Scholar