The Concept of Causation in Biology
- 447 Downloads
- 6 Citations
Abstract
This paper sets out to analyze how causation works by focusing on biology, as represented by epidemiology and by scientific information on how the body works (“physiology”). It starts by exploring the specificity of evolved physiological systems, in which evolutionary, developmental and proximal causes all fit together, and the concept of function is meaningful; in contrast, this structure does not apply in epidemiology (or outside biology). Using these two contrasting branches of biology, I examine the role both of mechanism and of difference making in causation. I find that causation necessarily involves both mechanism and difference making, and that they play complementary roles. Both are seen as ontologically necessary, even if the evidence is not always available for both. Influential monist accounts that focus on one of these, at the expense of ignoring the other, are found to be inadequate on these and on other grounds. Recent attempts to combine them are reviewed, notably that of Russo and Williamson (Int Stud Philos Sci 21:157–170, 2007), and it is argued that their epistemic view requires there to be a source of the different types of evidence that a rational agent would consider, and that this source must be ontic. I then analyze how causal relationships work in evolved physiological systems and in those studied by epidemiology, with a particular focus on how mechanism interacts with input. Finally, I consider this concept of causation from the perspective of everyday language, and of its possible generalisability outside biology.
Keywords
Causal Relationship Rickets Causal Claim Deterministic Causation Causal RelevanceReferences
- Bechtel, W. (2008). Mental mechanisms: Philosophical perspectives on cognitive neuroscience. New York: Routledge.Google Scholar
- Bechtel, W., & Abrahamsen, A. (2005). Explanation: A mechanist alternative. Studies in the History and Philosophy of the Biological and Biomedical Sciences, 36, 421–441.CrossRefGoogle Scholar
- Brilliant, M. H. (2008). Gene polymorphism and human pigmentation. US Department of Justice Document No. 223980. Retrieved November 13, 2012 from https://www.ncjrs.gov/pdffiles1/nij/grants/223980.pdf.
- Broadbent, A. (2011). Inferring causation in epidemiology: Mechanisms, black boxes, and contrasts. In P. McKay Illari, F. Russo, & J. Williamson (Eds.), Causality in the sciences. Oxford: Oxford University Press.Google Scholar
- Campaner, R., & Galavotti, M. C. (2007). Plurality in causality. In P. Machamer & G. Wolters (Eds.), Thinking about causes (pp. 178–199). Pittsburgh: Pittsburgh University Press.Google Scholar
- Cartwright, N. (1994). Nature’s capacities and their measurement. Oxford: Oxford University Press.CrossRefGoogle Scholar
- Cartwright, N. (2011). Evidence-based practice: mixing methods makes good practice. Presented at the CaEitS2011 conference: Causality and explanation in the sciences, Ghent, Belgium.Google Scholar
- Cartwright, N., & Pemberton J. (2012). Aristotelian powers: Without them, what would modern science do? In J. Greco & R. Groff (Eds.), Powers and capacities in philosophy: The new Aristotelianism (pp. 93–112). Routledge. Retrieved November 13, 2012 from http://personal.lse.ac.uk/PEMBERTO/AP%20v10.0.pdf.
- Craver, F. C. (2007). Explaining the brain: Mechanisms and the mosaic unity of neuroscience. Oxford: Clarendon Press.CrossRefGoogle Scholar
- Dowe, P. (2000). Physical causation. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
- Fisher, J. S., Macpherson, S., Marchetti, N., & Sharpe, R. M. (2003). Human ‘testicular dysgenesis syndrome’: A possible model using in utero exposure of the rat to dibutyl phthalate. Human Reproduction, 18, 1383–1394.CrossRefGoogle Scholar
- Glennan, S. (1996). Mechanisms and the nature of causation. Erkenntnis, 44, 49–71.CrossRefGoogle Scholar
- Glennan, S. (2002). Rethinking mechanistic explanations. Philosophy of Science, 69, S342–S353.CrossRefGoogle Scholar
- Glennan, S. (2008). Mechanisms. In S. Psillos & M. Curd (Eds.), The Routledge companion to the philosophy of science. London & New York: Routledge.Google Scholar
- Glennan, S. (2010a). Ephemeral mechanisms and historical explanation. Erkenntnis, 72, 251–266.CrossRefGoogle Scholar
- Glennan, S. (2010b). Mechanisms, causes, and the layered model of the world. Scholarship and Professional Work—LAS. Paper 73. Retrieved November 13, 2012 from http://digitalcommons.butler.edu/facsch_papers/73/.
- Glennan, S. (2011). Singular and general causal relations: A mechanist perspective. In P. McKay Illari, F. Russo, & J. Williamson (Eds.), Causality in the sciences. Oxford: Oxford University Press.Google Scholar
- Hall, N. (2004). Two concepts of causation. In J. Collins, N. Hall, & L. A. Paul (Eds.), Causation and counterfactuals. Cambridge, MA: Bradford Book/MIT Press.Google Scholar
- Hill, A. B. (1965). The environment and disease: Association or causation? Proceedings of the Royal Society of Medicine, 58, 295–300.Google Scholar
- Illari, P., & Williamson, J. (2012). What is a mechanism? Thinking about mechanisms across the sciences. European Journal for Philosophy of Science, 2, 119–135.CrossRefGoogle Scholar
- Joffe, M. (2010). What has happened to human fertility? Human Reproduction, 25, 295–307.CrossRefGoogle Scholar
- Joffe, M. (2011a). Causality and evidence discovery in epidemiology. In D. Dieks, W. J. Gonzalez, S. Hartmann, T. Uebel, & M. Weber (Eds.), Explanation, prediction, and confirmation. New trends and old ones reconsidered (pp. 153–166). Dordrecht: Springer.CrossRefGoogle Scholar
- Joffe, M. (2011b). The gap between evidence discovery and actual causal relationships. Preventive Medicine, 53, 246–249.CrossRefGoogle Scholar
- Joffe, M., Gambhir, M., Chadeau-Hyam, M., & Vineis, P. (2012). Causal diagrams in systems epidemiology. Emerging Themes in Epidemiology, 9, 1.CrossRefGoogle Scholar
- Knowles, J. R. (1970). On the mechanism of action of pepsin. Philosophical transactions of the Royal Society of London Series B, 257, 135–146.CrossRefGoogle Scholar
- Machamer, P., Darden, L., & Craver, C. F. (2000). Thinking about mechanisms. Philosophy of Science, 67, 1–25.CrossRefGoogle Scholar
- Neilson, H. K., Friedenreich, C. M., Brockton, N. T., & Millikan, R. C. (2009). Physical activity and postmenopausal breast cancer: Proposed biologic mechanisms and areas for future research. Cancer Epidemiology, Biomarkers and Prevention, 18, 11–27.CrossRefGoogle Scholar
- Norton, J. D. (2009). Is there an independent principle of causality in physics? British Journal for the Philosophy of Science, 60, 475–486.CrossRefGoogle Scholar
- Pearl, J. (2000). Causality: Models, reasoning and inference. New York: Cambridge University Press.Google Scholar
- Pearl, J. (2002). Causal inference in the health sciences: A conceptual introduction. Health Services and Outcomes Research Methodology, 2, 189–220.CrossRefGoogle Scholar
- Pemberton, J. (2011). Integrating mechanist and nomological machine ontologies to make sense of what-how-that causal evidence. Retrieved November 13, 2012 from http://personal.lse.ac.uk/pemberto/PNMO%20paper%20v6%200%20pdf.pdf.
- Psillos, S. (2004). A glimpse of the secret connexion: Harmonising mechanisms with counterfactuals. Perspectives on Science, 12, 288–319.CrossRefGoogle Scholar
- Rose, G. (2001). Sick individuals and sick populations. International Journal of Epidemiology, 30, 427–432. [first published 1985].CrossRefGoogle Scholar
- Ruse, M. (1973). The philosophy of biology (p. 195). London: Hutchinson & Co. Ltd.Google Scholar
- Russell, B. (1913). On the notion of cause. Proceedings of the Aristotelian Society, 13, 1–26.Google Scholar
- Russo, F. (2012). Correlational data, causal hypotheses, and validity. Journal of the General Philosophy of Science, 42, 85–107.CrossRefGoogle Scholar
- Russo, F., & Williamson, J. (2007). Interpreting causality in the health sciences. International Studies in the Philosophy of Science, 21, 157–170.CrossRefGoogle Scholar
- Russo, F., Wunsch, G., & Mouchart, M. (2011). Inferring causality through counterfactuals in observational studies. Some epistemological issues. Bulletin de Méthodologie Sociologique [Bulletin of Sociological Methodology], 111, 43–64.Google Scholar
- Strand, A., & Oftedal, G. (2009). Functional stability and systems level causation. Philosophy of Science, 76, 809–820.Google Scholar
- Strevens, M. (2007). Review of Woodward “making things happen”. Philosophy and Phenomenological Research, 74, 233–249.CrossRefGoogle Scholar
- Tabery, J. (2009). Difference mechanisms: Explaining variation within mechanisms. Biology and Philosophy, 24, 645–664.CrossRefGoogle Scholar
- Vineis, P., & Perera, F. (2007). Molecular epidemiology and biomarkers in etiologic cancer research: The new in light of the old. Cancer Epidemiology, Biomarkers and Prevention, 16, 1954–1965.CrossRefGoogle Scholar
- Woodward, J. (2003). Making things happen: A theory of causal explanation. New York: Oxford University Press.Google Scholar
- Woodward, J. (2010). Causation in biology: Stability, specificity, and the choice of levels of explanation. Biology and Philosophy, 25, 287–318.CrossRefGoogle Scholar
- Wouters, A. (2013). Explanation in biology. In W. Dubitzky , O. Wolkenhauer, H. Yokota, & K.-H. Cho (Eds.), Encyclopedia of systems biology. Dordrecht: Springer (in press).Google Scholar