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Occurrence of antibiotics in wastewater from hospital and convectional wastewater treatment plants and their impact on the effluent receiving rivers: current knowledge between 2010 and 2019

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Abstract

The increased usage of antibiotics over the recent years has been of great concern all over the world. It is estimated that about 100,000 tons to 200,000 tons of antibiotics are being consumed worldwide. This increased consumption of antibiotics is worrisome as this has resulted in their detection in wastewater treatment plants’ (WWTPs) effluent due to the inability of WWTP to remove them during treatment processes. The antibiotics may emanate from hospital effluents, surface waters, and sediments around the world. However, the migration of antibiotics to the environment is detrimental to public health since it can lead to antibiotics resistance in both humans and animals which has now been reported to be one of the biggest threats to public health in this twenty-first century. This present review work established from literature the presence, concentrations, and types of antibiotics both in influents and effluents of various waste treatment plants, natural water bodies, and hospital wastewaters from different countries over the past 10 years (2010–2019). A total of 78 published articles containing information on the presence of antibiotics in convectional and hospital wastewater and also in surface water were retrieved from scientific databases such as ScienceDirect, Google Scholar, PubMed, and Web of Science. A total of 39 different types of antibiotics from 10 different classes of antibiotics and others were recorded. Among the articles reviewed, the most frequently detected antibiotics are the classes of sulfonamides (sulfamethoxazole) which were present in almost all the WWTPs at concentrations as high as 10–800 ng/l in influent and 3600–68,700 ng/l in effluent samples. Macrolides (clarithromycin, erythromycin, azithromycin), trimethoprim, quinolones (ofloxacin, ciprofloxacin, norfloxacin), and tetracyclines (tetracycline) were also highly present in all treatment plants. β-Lactam antibiotics were seldom detected which might be due to hydrolysis. Most of the antibiotics present were recorded in Asian countries such as China and Singapore which have occurrence frequency of 6–30% and in European countries such as Greece and Spain with frequencies of about 6–10%. Future researches on the need for development of more reliable and cost-effective technologies for antibiotic removal such as advanced oxidation processes and remediation methods are suggested for more research attention.

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References

  • Ashfaq, M., Khan, K. N., Rasool, S., Mustafa, G., Saif-Ur-Rehman, M., Nazar, M. F., Sun, Q., & Yu, C. P. (2016). Occurrence and ecological risk assessment of fluoroquinolone antibiotics in hospital waste of Lahore, Pakistan. Environmental Toxicology and Pharmacology, 42, 16–22. https://doi.org/10.1016/j.etap.2015.12.015

    Article  CAS  Google Scholar 

  • Bizcommunity.com. (2018). https://m.bizcommunity.com/article/196/323/175316.html&ved1551424799335

  • Boleda, M. R., Galceran, M. T., & Ventura, F. (2013). Validation and uncertainty estimation of a multi residue method for pharmaceuticals in surface and treated waters by liquid chromatography–tandem mass spectrometry. Chromatography A, 1286, 146–158.

    Article  CAS  Google Scholar 

  • Boxall, A. B. A., Rudd, M. A., Brooks, B. W., Caldwell, D. J., Choi, K., Hickmann, S., Innes, E., Ostapyk, K., Staveley, J. P., Verslycke, T et al. (2012). Pharmaceuticals and personal care products in the environment: What are the big questions. Environmental Health Perspectives, 120, 1221–1229.

  • Center for Disease Dynamics, Economics & Policy. (2015). State of the world’s antibiotics. Washington, DC: CDDEP, 2015.

  • Chen, K., & Zhou, J. L. (2014). Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China. Chemosphere, 95, 604–612.

    Article  CAS  Google Scholar 

  • Chokshi, A., Sifri, Z., Cennimo, D., & Horng, H. (2019). Global contributors to antibiotics resistance. Global Infectious Diseases, 11, 36–42.

    Article  Google Scholar 

  • Ehealth news.co.za. (2018). https://ehealthnews.co.za/global-consuption-antibiotics-skyrockets/&ved1551424589712

  • Gao, L., Yali, S., Wenhui, L., Hongyun, N., Jiemin, L., & Yaqi, C. (2012). Occurrence of antibiotics in eight sewage treatment plants in Beijing, China. Chemosphere, 86, 665–671.

    Article  CAS  Google Scholar 

  • García-Galán, M. J., Díaz-Cruz, M. S., & Barceló, D. (2011). Occurrence of sulfonamide residues along the Ebro river basin: Removal in wastewater treatment plants and environmental impact assessment. Environment International, 37, 462–473.

    Article  Google Scholar 

  • Gavrilescu, M., Demnerova, K., Aamand, J., Agathos, S., & Fava, F. (2015). Emerging pollutants in the environment: Present and future challenges in biomonitoring, ecological risks and bioremediation. Journal New Biotechnology, 32, 147–156.

    Article  CAS  Google Scholar 

  • Golovko, O., Kumar, V., Fedorova, G., Randak, T., & Grabic, R. (2014). Seasonal changes in antibiotics, antidepressant/psychiatric drugs, antihistamines and lipids regulators in wastewater treatment plants. Chemosphere, 111, 418–426.

    Article  CAS  Google Scholar 

  • Gelband, H., Molly, M. P., Pant, S., Gandra, S., Levinson, J., Barter, D., White, A., & Laxminarayan, R. (2015). The state of the world’s antibiotics 2015. Wound Healing Southern Africa, 8(2015), 30–34.

  • Grenni, P., Ancona, V., & Caracciolo, A. B. (2018). Ecological effects of antibiotics on natural ecosystems: A review. Microchemical Journal, 136, 25–39.

  • Gros, M., Rodridguez-Mozaz, S., & Barcelo, D. (2013). Rapid analysis of multiclass antibiotics residue and some of their metabolites in hospital, urban wastewater and river water by ultra-high performance liquid chromatography coupled to quadropolelinear ion trap tandam mass spectrometry. Journal of Chromatology, 1292, 173–188.

    Article  CAS  Google Scholar 

  • Guerra, P., Kim, M., Shah, A., Alaee, M., & Smyth, S. A. (2014). Occurrence and fate of antibiotic, analgesic/anti-inflammatory, and antifungal compounds in five wastewater treatment processes. Science of the Total Environment, 473–474, 235–243.

    Article  Google Scholar 

  • Hanmin, Z., Pengxiao, L., Yujie, F., & Fenglin, Y. (2013). Fate of antibiotics during wastewater treatment and antibiotic distribution in the effluent-receiving waters of the Yellow Sea, northern China. Marine Pollution Bulletin, 73, 282–290.

    Article  Google Scholar 

  • He, Ke., Ethan, H., Anne, T., Mitchell, T., & Lee, B. (2019). Occurrence of antibiotics, estrogenic hormones, and UV-filters in water, sediment, and oyster tissue from the Chesapeake Bay. Science of the Total Environment, 650, 3101–3109.

    Article  CAS  Google Scholar 

  • Hossain, A., Shihori, N., Habillah-Al-Mamun, M. D., Keiichiro, T., Shigeki, M., & Hiroyuki, M. (2018). Occurrence and ecological risk of pharmaceuticals in river surface water of Bangladesh. Environmental Research, 165, 258–266.

    Article  CAS  Google Scholar 

  • Huang, M. H., Zhang, W., Liu, C., & Hu, H. Y. (2015). Fate of trace tetracycline with resistant bacteria and resistance genes in an improved AAO wastewater treatment plant. Process Safety and Environmental Protection, 93, 68–74.

  • Jian, X., Yan, X., Hongmei, W., Changsheng, G., Huiyun, Q., Yan, H., Yuan, Z., Xiaochen, L., & Wei, M. (2015). Occurrence of antibiotics and antibiotic resistance genes in a sewage treatment plant and its effluent-receiving river. Chemosphere, 119, 1379–1385.

  • Jiang, Y., Li, M., Guo, C., An, D., Xu, J., Zhang, Y., & Xi, B. (2014). Distribution and ecological risk of antibiotics in a typical effluent-receiving river (Wangyang River) in north China. Chemosphere, 112, 267–274.

    Article  CAS  Google Scholar 

  • Jing, H., Juan, Z., Shaoqi, Z., Pan, W., & Yiu, F. T. (2018). Occurrence and fate of antibiotics in a wastewater treatment plant and their biological effects on receiving waters in Guizhou. Journal Process Safety and Environmental Protection, 113, 483–490.

    Article  Google Scholar 

  • Julia, R., Sara, S., Robert, G., Reinhard, O., & Wilhelm, K. (2014). Simultaneous determination of most prescribed antibiotics in multiple urban wastewaters by SPE-LC-MS/MS. Journal of Chromatography B, 969, 162–170.

    Article  Google Scholar 

  • Klein, J. O. (1997). History of macrolide use in pediatrics. Pediatric Infectious Disease Journal, 16(4), 427–431. https://vpn.lib.ucdavis.edu/sp-3.15.1b/,DanaInfo=ovidsp.tx.ovid.com+ovidweb.cgi?QS2=434f4e1a73d37e8c5a069e886e3737f26717dae44a2a2d92c6e716fb60d3c17d1c6d8ea2372e4ec4cb0b260e9c03c8731fc5722353b49991b8b834dfb4bcdfc3e9c0148c670b61c432cae0a00dcc5fce6c066a02c4d

  • Klein, Y. E., Thomas, P., Van, B., Elena, M. M., Suraj, P., Sumanth, G., Simon, A., Levin, H. G., & Ramanan, L. (2017). Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proceedings of the National Academy of Sciences, 115, 3463–3470. https://doi.org/10.1073/pnas.1717295115

  • K’oreje, K. O., Vergeynst, L., Ombaka, D., De Wispelaere, P., Okoth, M., Van, L. H., & Demeestere, K. (2016). Occurrence patterns of pharmaceutical residues in wastewater, surface water and groundwater of Nairobi and Kisumu city, Kenya. Chemosphere, 149, 238–244.

    Article  CAS  Google Scholar 

  • Kosma, C. I., Lambropoulou, D. A., & Albanis, T. A. (2014). Investigation of PPCPs in waste water treatment plants in Greece: Occurrence, removal and environmental risk assessment. Science of Total Environment, 466–467, 421–438.

    Article  Google Scholar 

  • Ladislav, M., Eleni, K., Nikolaos, S., Mira, P., & Sergi, S. (2018). Contamination patterns and attenuation of pharmaceuticals in a temporary Mediterranean river 2018.

  • La Thi, Q. L., Nguyen, Q. H., Nguyen, T. K. C., Nguyen, T. M. T., Ho, D. P., Vishal, D., Nguyen, T. D., Ashok, J. T., & Cecilia, S. L. (2016). Antibiotics in wastewater of a rural and an urban hospital before and after wastewater treatment, and the relationship with antibiotic use—a one year study from Vietnam. International Journal of Environmental Research and Public Health, 13(6), 588–599. https://doi.org/10.3390/ijerph13060588. PMCID: PMC4924045 PMID: 27314366.

  • Li, W. C. (2014). Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil. Environmental Pollution, 187, 193–201.

    Article  CAS  Google Scholar 

  • Llor C., & Bjerrum L. (2016). Antibiotic prescribing for acute bronchitis. Expert Review of Anti-Infective Therapy, 14(7), 633–642. https://doi.org/10.1080/14787210.2016.1193435

  • López-Serna, R., Mira, P., & Damià, B. (2012). Occurrence and distribution of multi-class pharmaceuticals and their active metabolites and transformation products in the Ebro River basin (NE Spain). Science of the Total Environment, 440, 280–289.

    Article  Google Scholar 

  • Lorenzo, P., Anzil, A., Subirats, J., Borrego, C., Farre, M., Llorca, M., Balcazar, J.L., & Servais, P. (2018). Antibiotic resistance in urban and hospital wastewaters and their impact on a receiving freshwater ecosystem. Chemosphere, 206, 70–82.

  • Madikizela, L. M., Nikita, T. T., & Luke, C. (2017). Status of pharmaceuticals in African water bodies: Occurrence, removal and analytical methods. Journal of Environmental Management, 193(2017), 211–220.

    Article  CAS  Google Scholar 

  • Mandaric, L., Kalogianni, E., Skoulikidis, N., Petrovic, M., & Sabater, S. (2019). Science of the Total Environment Contamination patterns and attenuation of pharmaceuticals in a temporary Mediterranean river. Science of the Total Environment, 647, 561–569. https://doi.org/10.1016/j.scitotenv.2018.07.308

    Article  CAS  Google Scholar 

  • Matongo, S., Grace, B., Brenda, M., & Patrick, N. (2015). Occurrence of selected pharmaceuticals in water and sediment of Umgeni River, KwaZulu-Natal, South Africa. Environmental Science and Pollution Research, 22, 10298–10308. https://doi.org/10.1007/s11356-015-4217-0

  • Mendoza, A., Aceña, J., Pérez, S., Lópezde, A. M., Barceló, D., Gil, A., & Valcárcel, Y. (2015). Pharmaceuticals and iodinated contrast media in a hospital wastewater: A case study to analyse their presence and characterize their environmental risk and hazard. Environmental Research, 140, 225–241.

    Article  CAS  Google Scholar 

  • Michael, I., Rizzo, L., McArdell, C. S., Manaia, C. M., Merlin, C., Schwartz, T., et al. (2013). Urban waste water treatment plants as hotspots for the release of antibiotics in the environment: A review. Water Research, 47, 957–995.

    Article  CAS  Google Scholar 

  • Mirzaei, R., Mesdaghinia, A., Hoseini, S. S., & Yunesian, M. (2019). Antibiotics in urban wastewater and rivers of Tehran, Iran: Consumption, mass load, occurrence, and ecological risk. Chemosphere, 221, 55–66. https://doi.org/10.1016/j.chemosphere.2018.12.187

  • Mohapatra, S., Ching-Hua, H., Suparna, M., & Lokesh, P. P. (2016). Occurrence and fate of pharmaceuticals in WWTPs in India and comparison with a similar study in the United States. Chemosphere, 159, 526–535.

    Article  CAS  Google Scholar 

  • Nadeem, A. K., Sirajuddin, A., Izharul, H. F., Imran, A., Vambol, V., Fazlollah, C., Mahmood, Y., Sergij, V., Saif, U. K., & Afzal, H. K. (2020). Occurrence, sources and conventional treatment techniques for various antibiotics present in hospital wastewaters: A critical review. Trends in Analytical Chemistry, 129, 115921. https://doi.org/10.1016/j.trac.2020.115921

  • National department of health. (2018). Surveillance for antimicrobial resistance and consumption of antibiotics in South Africa. http://www.health.gov.za

  • Ngumba, E., Gachanja, A., & Tuhkanen, T. (2016). Occurrence of selected antibiotics and antiretroviral drugs in Nairobi River Basin, Kenya. Science of Total Environment, 539, 206–213.

    Article  CAS  Google Scholar 

  • Ocsana, O., Ristiou, D., & Maria-loredana, S. (2013). Determination of some frequently used antibiotics in waste water using solid phase extraction followed by high performance liquid chromatography with diode array and mass spectrome. Journal of Chemistry, 8, 1343–1351. https://doi.org/10.2478/s11532-013-0263-y

    Article  CAS  Google Scholar 

  • Olarinmoye, O., Bakare, A., Ugwumba, O., & Hein, A. (2016). Quantification of pharmaceutical residues in wastewater impacted surface waters and sewage sludge from Lagos, Nigeria. Journal of Environmental Chemistry and Ecotoxicology, 8, 14–24.

    Article  CAS  Google Scholar 

  • Pacific Standard. (n.d.). The Wasteful Disposal of Prescription Drugs From America’s Nursing Homes. PACIFIC STANDARD STAFF UPDATED: JUN 14, 2017 ORIGINAL: APR 28, 2017 BY ALLEN MARSHALL ALLEN

  • Paíga, P., Santos, L. H., Ramos, S., Jorge, S., Silva, J. G., & Delerue-Matos, C. (2016). Presence of pharmaceuticals in The Lis River (Portugal): sources, fate and seasonal variation. Science of the Total Environment, 573, 164–177

  • Paola, B., & Sergio, C. (2017). Presence of residues and metabolites of pharmaceuticals in environmental compartments, food commodities and workplaces: A review spanning the three-year period 2014–2016. Microchemical Journal, 136(2018), 2–24.

    Google Scholar 

  • Papageorgiou, M., Christina, K., & Dimitra, L. (2016). Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece. Science of the Total Environment, 543, 547–569.

    Article  CAS  Google Scholar 

  • Pärnänen, K. M., Narciso-da-Rocha, C., Kneis, D., Berendonk, T. U., Cacace, D., Do, T. T., Elpers, C., Fatta-Kassinos, D., Henriques, I., & Jaeger, T. (2019). Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence. Science Advances, 5(3).

  • Pharmadynamics.co.za. (2018). http://pharmadynamics.co.za/way-to-many-sa-doctors-still-prescribingantibiotics/&ved1551424709989

  • Proia, L., Lupini, G., Osorio, V., Pérez, S., Barceló, D., Schwartz, T., Amalfitano, S., Fazi, S., Romaní, A. M., & Sabater, S. (2013). Response of biofilm bacterial communities to antibiotic pollutants in a Mediterranean river. Chemosphere, 92, 1126–1135.

  • Rachna, S., Akhand, P. S., Sunil, K., & Balendu, S. G. (2019). Antibiotics resistance in major rivers in the world: A systematic review on occurrence, emergence and management strategies. Journal of Cleaner Production, 234, 1484–1505.

    Article  Google Scholar 

  • Rehman, M. S. U., Rashid, N., Ashfaq, M., Saif, A., Ahmad, N., & Han, J. I. (2015). Global risk of pharmaceutical contamination from highly populated developing countries. Chemosphere, 138(2015), 1045–1055.

  • Reis-Santos, P., Pais, M., Duarte, B., Cacador, I., Freitas, A., Vila, P. A. S., Babosa, J., Leston, S., Rosa, J., Ramos, F., Cabral, H. N., Gillanders, B. M., & Fonseca, V. F. (2018). Screening of human and veterinarypharmaceuticals in estuarine waters: a baseline assessment for Tejo estuary. Marine Pollution Bulletin, 135, 1079–1084.

  • Rodriguez-Mozaz, S., Chamorro, S., Marti, E., Huerta, B., Gros, M., Sànchez-Melsió, A., Borrego, C. M., Barceló, D., & Balcázar, J. L. (2015). Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river. Water Research, 69, 234–242. https://doi.org/10.1016/j.watres.2014.11.021

    Article  CAS  Google Scholar 

  • Rodríguez-Mozaz, S., & Howard, S. W. (2010). Meeting report: pharmaceuticals in water—an interdisciplinary approach to a public health challenge environmental health perspectives. 118, 1016–20. https://doi.org/10.1289/ehp.0901532

  • Roya, M., Masud, Y., Simin, N., Mitra, G., Esfandiyar, J., Shahram, S., & Alireza, M. (2018). Occurrence and fate of most prescribed antibiotics in different water environments of Tehran, Iran. Science of the Total Environment, 619–620, 446–459.

    Google Scholar 

  • Sabria, N. A., Schmittb, H., Van der, Z., & B., Gerritsend, H. W., Zuidemad, T., Rijnaartsa, H. H. M., & Langenho, A. A. M. (2018). Prevalence of antibiotics and antibiotic resistance genes in a wastewater effluent-receiving river in the Netherlands Journal of Environmental. Chemical Engineering. https://doi.org/10.1016/j.jece.2018.03.004

    Article  Google Scholar 

  • Senta, I., Terzic, S., & Ahel, M. (2013). Occurrence and fate of dissolved and particulate antimicrobials in municipal waste water treatment. Water Research, 47, 705–714.

    Article  CAS  Google Scholar 

  • Shuaa, A.-M., Ipek, G., Aishah, B. A. L., & B. S. (2019). Antibiotics in hospital effluent and domestic wastewater treatment plants in Doha, Qatar. Journal of Water Processing Engineering, 28, 60–68.

    Article  Google Scholar 

  • Su-fen, Y., Ze-hua, L., Hua, Y., Zhi, D., Ping-xiao, W., Neng-wu, Z., & Zhang, L. (2019). Trace determination of sulfonamide antibiotics and their metabolites via SPE-LC-MS/MS in wastewater and insights from their occurrence in a municipal wastewater. Science of Total Environment, 653, 815–821.

    Article  Google Scholar 

  • Tahrani, L., Joris, V. L., Roel, A., Luc, V., Hedi Ben Mansour., & Tim Reyns. (2017). Identification and risk assessment of human and veterinary antibiotics in the wastewater treatment plants and the adjacent sea in Tunisia. Water Science & Technology | ISS, 76(11), 3000–3021. https://doi.org/10.2166/wst.2017.465

  • Tang, J., Shi, T., Wu, X., Cao, H., Li, X., Hua, R., Tang, F., & Yue, Y. (2015). The occurrence and distribution of antibiotics in Lake Chaohu, China: Seasonal variation, potential source and risk assessment. Chemosphere, 122, 154–161.

  • Thomas, P. V. B., Sumanth, G., Ashvin, A., Quentin, C., Bryan, T. G., Simon, A. L., & Ramanan, L. (2014). Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. The Lancet Infectious Diseases, 14, 742–50. https://doi.org/10.1016/S1473-3099

  • Tran, N. H., Hongjie, C., Martin, R., Feijian, M., & Karina, Y.-H.G. (2016). Occurrence and removal of multiple classes of antibiotics and antimicrobial agents in biological wastewater treatment processes. Water Research, 104, 461–472.

  • Urszula, S., Marek, W., Ireneusz, S., Jarosław, K., Gabriela, W., & Mateusz, K. W. (2019). Presence of antibiotics in the aquatic environment in Europe and their analytical monitoring: Recent trends and perspectives. Microchemical Journal, 147, 729–740.

    Article  Google Scholar 

  • Van Boeckel, T. P., Pires, J., Silvester, R., Zhao, C., Song, J., Criscuolo, N. G., Gilbert, M., Bonhoeffer, S., & Laxminarayan, R. (2019). Global trends in antimicrobial resistance in animals in low-and middle-income countries. Science, 365(6459), eaaw1944.

  • Verlicchi, P., Al Aukidy, M., Galletti, A., Petrovic, M., & Barceló, D. (2012). Hospital effluent: Investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment. Science of the Total Environment, 430, 109–118.

  • Verlicchi, P., Al Aukidy, M., Jelic, A., Petrović, M., & Barceló, D. (2014). Comparison of measured and predicted concentrations of selected pharmaceuticals in wastewater and surface water: A case study of a catchment area in the Po Valley (Italy). Science of the Total Environment, 470–471, 844–854.

  • Violette, G., Hans, M., Erwin, K., Gunter, U., Marti, N., Maetine, V. D. P., Sjoerd, E. A. T. M. Z., & Coen, J. R. (2015). Emerging pollutants in the environment: A challenge for water resource management. Journal for International Soil and Water Conservation Research, 3, 57–65.

  • Vishal, D., Ashok, J. T., Manjeet, A., Shanta, S., Rakesh, K. K., & Cecilia, S. L. (2010). Detection of antibiotics in hospital effluents in India. https://www.researchgate.net/publication/228856836

  • Wang, H. W. B., Zhao, Q., Zhao, Y., Fu, C., Feng, X., Wang, N., Su, M., Tang, C., & Jiang, F. (2015). Antibiotic body burden of Chinese school children: a multisite bio monitoring-based study 2015.

  • Wang, J., Libing, C., László, W., & Erzsébet, T. (2020). Occurrence and fate of antibiotics, antibiotic resistant genes (ARGs) and antibiotic resistant bacteria (ARB) in municipal wastewater treatment plant: An overview. Science of the Total Environment, 744, 140997. https://doi.org/10.1016/j.scitotenv.2020.140997

  • Wang, R., Min, J., Hongyan, Z., Yuing, G., Yuan, L. (2021). Occurrence of antibiotics resistance genes in WWTP effluent receiving water bodies and reclaimed wastewater treatment plants. Science of Total Environment, 796, 148919.

  • Wenjing, D., Na, L., Hailong, Z., & Huiying, L. (2016). Occurrence and risk assessment of antibiotics in river water in Hong Kong. Ecotoxicology and Environmental Safety, 125, 121–127.

    Article  Google Scholar 

  • Willis, G., & Nhamo, C. (2018). Organic contaminants in African aquatic systems: Current knowledge, health risks, and future research directions. Science of the Total Environment, 619–620, 1493–1514.

    Google Scholar 

  • World Health Organization. (2014). Antimicrobial Resistance: Global Report on Surveillance 2014. Environmental Science & Technology, 49, 5070–5079. Available online http://www.who.int/en/. Accessed on 6 February 2017.

  • World Health Organization. (2018). WHO Report on survelliance of antibiotics consumption: 2016–2018 early implementations Geneva: CC BY-NC-SA 3.0IGO.

  • Yang, J. F., Ying, G. G., Zhao, J. L., Tao, R., Su, H. C., & Liu, Y. S. (2011). Spatial and seasonal distribution of selected antibiotics in surface waters of the Pearl Rivers, China. Journal of Environmental Science and Health Part. B, 46, 272–280.

    Article  Google Scholar 

  • Ying, H., Xue, Y., Yun, S., Mingxiao, D., & Jun, W. (2018). Antibiotics in surface water and sediments from Hanjiang River, Central China: Occurrence, behavior and risk assessment. Ecotoxicology and Environmental Safety, 157, 150–158.

    Article  Google Scholar 

  • Younes, H. A., Mahmoud, H. M., Abdelrahman, M. M., & Nassar, H. F. (2019). Seasonal occurrence, removal efficiency and associated ecological risk assessment of three antibiotics in a municipal wastewater treatment plant in Egypt. Environmental Nanotechnology, Monitoring and Management, 12(June), 100239. https://doi.org/10.1016/j.enmm.2019.100239

  • Zhang, R. J., Zhang, G., Zheng, Q., Tang, J., Chen, Y., Xu, W., Zou, Y., & Chen, X. (2012). Occurrence and risks of antibiotics in the Laizhou Bay, China: Impacts of river discharge. Ecotoxicology and Environmental Safety, 80, 208–215.

  • Zhou, L. J., Ying, G. G., Liu, S., Zhao, J. L., Yang, B., Chen, Z. F., & Lai, H. J. (2013). Occurrence and fate of eleven classes of antibiotics in two typical wastewater treatment plants in South China. Science of the Total Environment, 452–453, 365–376. https://doi.org/10.1016/j.scitotenv.2013.03.010

    Article  CAS  Google Scholar 

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  1. Department of Chemistry, Sefako Makgatho Health Sciences University, Pretoria, South Africa

    Loveth Oke Omuferen & B. Maseko

  2. Department of Biology, Sefako Makgatho Health Sciences University, Pretoria, South Africa

    J. O. Olowoyo

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Omuferen, L.O., Maseko, B. & Olowoyo, J.O. Occurrence of antibiotics in wastewater from hospital and convectional wastewater treatment plants and their impact on the effluent receiving rivers: current knowledge between 2010 and 2019. Environ Monit Assess 194, 306 (2022). https://doi.org/10.1007/s10661-022-09846-4

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