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Sources, mechanisms, and fate of steroid estrogens in wastewater treatment plants: a mini review

  • Yien Fang Ting
  • Sarva Mangala PraveenaEmail author
Article

Abstract

Steroid estrogens, such as estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2), are natural and synthetic hormones released into the environment through incomplete sewage discharge. This review focuses on the sources of steroid estrogens in wastewater treatment plants (WWTPs). The mechanisms and fate of steroid estrogens throughout the entire wastewater treatment system are also discussed, and relevant information on regulatory aspects is given. Municipal, pharmaceutical industry, and hospitals are the main sources of steroid estrogens that enter WWTPs. A typical WWTP comprises primary, secondary, and tertiary treatment units. Sorption and biodegradation are the main mechanisms for removal of steroid estrogens from WWTPs. The fate of steroid estrogens in WWTPs depends on the types of wastewater treatment systems. Steroid estrogens in the primary treatment unit are removed by sorption onto primary sludge, followed by sorption onto micro-flocs and biodegradation by microbes in the secondary treatment unit. Tertiary treatment employs nitrification, chlorination, or UV disinfection to improve the quality of the secondary effluent. Activated sludge treatment systems for steroid estrogens exhibit a removal efficiency of up to 100%, which is higher than that of the trickling filter treatment system (up to 75%). Moreover, the removal efficiency of advance treatment systems exceeds 90%. Regulatory aspects related to steroid estrogens are established, especially in the European Union. Japan is the only Asian country that implements a screening program and is actively involved in endocrine disruptor testing and assessment. This review improves our understanding of steroid estrogens in WWTPs, proposes main areas to be improved, and provides current knowledge on steroid estrogens in WWTPs for sustainable development.

Keywords

Steroid estrogens Wastewater treatment system Sources Fate Mechanisms Regulatory 

References

  1. Andersen, H. R., Hansen, M., Kjolholt, J., Stuer-Lauridsen, F., Ternes, T., & Halling-Sorensen, B. (2005). Assessment of the importance of sorption for steroid estrogens removal during activated sludge treatment. Chemosphere, 61, 139–146.CrossRefGoogle Scholar
  2. Andersen, H., Siegrist, H., Halling-Sorensen, B., & Ternes, T. A. (2003). Fate of estrogens in a municipal sewage treatment plant. Environmental Sciences and Technology, 37(18), 4021–4026.CrossRefGoogle Scholar
  3. Atkinson, S. K., Marlatt, V. L., Kimpe, L. E., Lean, D. R. S., Trudeau, V. L., & Blais, J. M. (2012). The occurrence of steroidal estrogens in south eastern Ontario wastewater treatment plants. Science of the Total Environment, 430, 119–125.CrossRefGoogle Scholar
  4. Avbersek, M., Somen, J., & Heath, E. (2011). Dynamics of steroid estrogen daily concentrations in hospital effluent and connected waste water treatment plant. Journal of Environmental Monitoring, 13, 2221.CrossRefGoogle Scholar
  5. Aziz, H.A., Mojiri, A., Ghobahi, Y., & Zarbakhsh, M. (2014). Wastewater engineering: advanced wastewater treatment systems. International Journal of Scientific Research Books, IJSR Publications, ISSN, 2322–4657.Google Scholar
  6. Behera, S. K., Kim, H. W., Oh, J. E., & Park, H. S. (2011). Occurrence and removal of antibiotics, hormones, and several other pharmaceuticals in wastewater treatment plants of the largest industry city of Korea. The Science of the Total Environment, 409, 4351–4360.CrossRefGoogle Scholar
  7. Braga, O., Smythe, G. A., Schafer, A. I., & Feitz, A. J. (2005). Fate of steroid estrogens in Australian inland and coastal wastewater treatment plants. Environmental Science & Technology, 39, 3351–3358.CrossRefGoogle Scholar
  8. Cajthaml, T., Kresinova, Z., Svobodova, K., Sigler, K., & Rezanka, T. (2009). Microbial transformation of synthetic estrogen 17α-ethinylestradiol. Environmental Pollution, 157, 3325–3335.CrossRefGoogle Scholar
  9. Campbell, C. G., Borglin, S. E., Green, F. B., Grayson, A., Wozei, E., & Stringfellow, W. T. (2006). Biologically directed environmental monitoring, fate, and transport of estrogenic endocrine disrupting compounds in water: a review. Chemosphere, 65, 1265–1280.CrossRefGoogle Scholar
  10. Chang, H., Wan, Y., Wu, S., Fan, Z., & Hu, J. (2011). Occurrence of androgens and progestrogens in wastewater treatment plants and receiving river waters: comparison to estrogens. Water Research, 45, 732–740.CrossRefGoogle Scholar
  11. Chimchirian, R. F., Suri, R. P., & Fu, H. (2007). Free synthetic and natural estrogen hormones in influent and effluent of three municipal wastewater treatment plants. Water Environment Research, 79(9), 969–974.CrossRefGoogle Scholar
  12. Clara, M., Kreuzinger, N., Strenn, B., Gans, O., & Kroiss, H. (2005). The solids retention time—a suitable design parameter to evaluate the capacity of wastewater treatment plants to remove micropollutants. Water Research, 39, 97–106.CrossRefGoogle Scholar
  13. Clara, M., Strenn, B., Saracevic, E., & Kreuzinger, N. (2004). Adsorption of bisphenol-A, 17β-estradiole and 17α-ethinylestradiole to sewage sludge. Chemosphere, 56, 843–851.CrossRefGoogle Scholar
  14. Combalbert, S., & Hernandez-Raquet, G. (2010). Occurrence, fate, and biodegradation of estrogens in sewage and manure. Applied Microbial and Biotechnology, 86, 1671–1692.CrossRefGoogle Scholar
  15. Cui, C. W., Ji, S. L., & Ren, H. Y. (2006). Determination of steroid estrogens in wastewater treatment plant of a contraceptives producing factory. Environmental Monitoring and Assessment, 121, 409–419.CrossRefGoogle Scholar
  16. Cunha, D. L., Silva, S. M. C., Bila, D. M., Mota, O. J. L., Novaes, S. P., & Larentis, A. L. (2016). Regulation of the synthetic estrogen 17α-ethinylestradiol in water bodies in Europe, the United States, and Brazil Cad Saude Publica. Rio de Janeiro., 32(3), 56715.Google Scholar
  17. Diniz, M. S., Mauricio, R., Petrovic, M., Alda, M. J. L., Amaral, L., Peres, I., Barcelo, D., & Santana, F. (2010). Assessing the estrogenic potency in a Portuguese wastewater treatment plant using an integrated approach. Journal of Environmental Sciences, 22(10), 1613–1622.CrossRefGoogle Scholar
  18. Directive 2000/60/EC of the European Parliament and of the Council of 23rd October 2000.Google Scholar
  19. Directive 2008/105/EC of the European Parliament and of the Council of 16th December 2008.Google Scholar
  20. Directive 2013/39/EU of the European Parliament and of the Council of 12th August 2013.Google Scholar
  21. Esperanza, M., Suidan, M. T., Marfil-Vega, R., Gonzalez, C., Sorial, G. A., McCauley, P., & Brenner, R. (2007). Fate of sex hormones in two pilot scale municipal wastewater treatment plants: conventional treatment. Chemosphere, 66, 1535–1544.CrossRefGoogle Scholar
  22. Guedes-Alonso, R., Montesdeoca-Esponda, S., Sosa-Ferrera, Z., & Santana-Rodriguez, J. J. (2014). Liquid chromatography methodologies for the determination of steroid hormones in aquatic environmental systems. Trends in Environmental Analytical Chemistry, 3, 14–27.CrossRefGoogle Scholar
  23. Hamid, H., & Eskicioglu, C. (2012). Fate of estrogenic hormones in wastewater and sludge treatment: a review of properties and analytical detection techniques in sludge matrix. Water Research, 46, 5813–5833.CrossRefGoogle Scholar
  24. Hashimoto, T., Onda, K., Nakamura, Y., Tada, K., Miya, A., & Murakami, T. (2007). Comparison of natural estrogen removal efficiency in the conventional activated sludge process and the oxidation ditch process. Water Research, 41, 2117–2126.CrossRefGoogle Scholar
  25. Hecker, M., & Hollert, H. (2011). Endocrine disruptor screening: regulatory perspectives and needs. Environmental Sciences Europe, 23, 15.CrossRefGoogle Scholar
  26. Huang, B., Li, X., Sun, W., Ren, D., Li, X., Li, X., Liu, Y., Li, Q., & Pan, X. (2014). Occurrence, removal, and fate of progestrogens, androgens, estrogens, and phenols in six sewage treatment plants around Dianchi Lake in China. Environmental Science and Pollution Research, 21, 12898–12908.CrossRefGoogle Scholar
  27. Johnson, A. C., Belfroid, A., & Corcia, A. D. (2000). Estimating steroid oestrogen inputs into activated sludge treatment works and observations on their removal from the effluent. Science of the Total Environment, 256, 163–173.CrossRefGoogle Scholar
  28. Johnson, A. C., & Sumpter, J. P. (2001). Removal of endocrine-disrupting chemicals in activated sludge treatment works. Environmental Science and Technology, 35(24), 4697–4703.CrossRefGoogle Scholar
  29. Jugan, M. L., Oziol, L., Bimbot, M., Huteau, V., Tamisier-Karolak, S., Blondeau, J. P., & Levi, Y. (2009). In vitro assessment of thyroid and estrogenic endocrine disruptors in wastewater treatment plants, rivers, and drinking water supplies in the greater Paris area (France). Science of the Total Environment, 407, 3579–3587.CrossRefGoogle Scholar
  30. Jurado, A., Vazquez-Sune, E., Carrera, J., Alda, M. L., Pujades, E., & Barcelo, D. (2012). Emerging organic contaminants in groundwater in Spain: a review of sources, recent occurrence and fate in European context. Science of the Total Environment, 440, 82–94.CrossRefGoogle Scholar
  31. Khanal, S. K., Xie, B., Thompson, M. L., Sung, S., Ong, S. K., & Leeuwen, J. (2006). Fate, transport, and biodegradation of natural estrogens in the environment and engineered systems. Environmental Science and Technology, 40(21), 6536–6546.CrossRefGoogle Scholar
  32. Koh, Y. K. K., Chiu, T. Y., Boobis, A., Cartmell, E., Lester, J. N., & Scrimshaw, M. D. (2007). Determination of steroid estrogens in wastewater by high performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1173, 81–87.CrossRefGoogle Scholar
  33. Koh, Y. K. K., Chiu, T. Y., Boobis, A., Cartmell, E., Scrimshawm, M. D., & Lester, J. N. (2008). Treatment and removal strategies for estrogens from wastewater. Environmental Technology, 29, 245–267.CrossRefGoogle Scholar
  34. Kolodziej, E. P., Harter, T., & Sedlak, D. L. (2004). Dairy wastewater, aquaculture, and spawning fish as sources of steroid hormones in the aquatic environment. Environmental Science and Technology, 38(22), 6377–6384.CrossRefGoogle Scholar
  35. Kumar, V., Nakada, N., Yasojima, M., Yamashita, N., Johnson, A. C., & Tanaka, H. (2011). The arrival and discharge of conjugated estrogens from a range of different sewage treatment plants in the UK. Chemosphere, 82, 1124–1128.CrossRefGoogle Scholar
  36. Kuster, M., Lopez de Alda, M. J., Hernando, M. D., Petrovic, M., Martin-Alonso, J., & Barcelo, D. (2008). Analysis and occurrence of pharmaceuticals, estrogens, progestrogens and polar pesticides in sewage treatment plant effluents, river water and drinking water in the Llobregat river basin (Barcelona, Spain). Journal of Hydrology, 358, 112–123.CrossRefGoogle Scholar
  37. Lagana, A., Bacaloni, A., Leva, I., Faberi, A., Fago, G., & Marino, A. (2004). Analytical methodologies for determining the occurrence of endocrine disrupting chemicals in sewage treatment plants and natural waters. Analytica Chimica Acta, 501, 79–88.CrossRefGoogle Scholar
  38. Lai, K. M., Johnson, K. L., Scrimshw, M. D., & Lester, J. N. (2000). Binding of waterborne steroid estrogens to solid phases in river and estuarine systems. Environmental Science and Technology, 34, 3890–4000.CrossRefGoogle Scholar
  39. Laurenson, J.P., Bloom, R.A, Page, S., & Sadrieh, N. (2014). Ethinyl estradiol and other human pharmaceutical estrogens in environment: a review of recent risk assessment data. American Association of Pharmaceutical Scientists, 16(2), 299–310.Google Scholar
  40. Layton, A. C., Gregory, B. W., Seward, J. R., Schultz, T. W., & Sayler, G. S. (2000). Mineralization of steroidal hormones by biosolids in wastewater treatment systems in Tennessee U.S.A. Environmental Science and Technology, 34, 3925–3931.CrossRefGoogle Scholar
  41. Lee, H. B., & Liu, D. (2002). Degradation of 17β-estradiol and its metabolites by sewage bacteria. Water Air Soil Pollution, 134, 353–368.CrossRefGoogle Scholar
  42. Leusch, F. D. L., Chapman, H. F., Heuvel, M. R., Tan, B. L. L., Gooneratne, S. R., & Tremblay, L. A. (2006). Bioassay-derived androgenic and estrogenic activity in municipal sewage in Australia and New Zealand. Ecotoxicology and Environmental Safety, 65, 403–411.CrossRefGoogle Scholar
  43. Li, Y.M., Zeng, Q.L., & Yang, S.J. (2011). Removal and fate of estrogens in an anaerobic-anoxic-oxic activated sludge system. Water Science and Technology, 51–56.Google Scholar
  44. Lishman, L., Smyth, S. A., Sarafin, K., Kleywegt, S., Toito, J., Peart, T., Lee, B., Servos, M., Beland, M., & Seto, P. (2006). Occurrence and reductions of pharmaceuticals and personnel care products and estrogens by municipal wastewater treatment plants in Ontario, Canada. Science of the Total Environment, 367, 544–558.CrossRefGoogle Scholar
  45. Liu, Z. H., Ogejo, J. A., Pruden, A., & Knowlton, K. F. (2011). Occurrence, fate and removal of synthetic oral contraceptives (SOCs) in the natural environment: a review. Science of the Total Environment, 409, 5149–5161.CrossRefGoogle Scholar
  46. Liu, S., Ying, G. G., Zhao, J. L., Zhou, L. J., Yang, B., Chen, Z. F., & Lai, H. J. (2012). Occurrence and fate of androgens, estrogens, glucocorticoids and progestagens in two different types of municipal wastewater treatment plants. Journal of Environmental Monitoring, 14, 482.CrossRefGoogle Scholar
  47. Luo, Y. L., Guo, W. S., Ngo, H. H., Nghiem, L. D., Hai, F. I., Zhang, J., Liang, S., & Wang, X. C. (2014). A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment. Science of the Total Environment, 473-474, 619–641.CrossRefGoogle Scholar
  48. Ma, M., Rao, K., & Wang, Z. (2007). Occurrence of estrogenic effect in sewage and industrial wastewaters in Beijing, China. Environmental Pollution, 147, 331–336.CrossRefGoogle Scholar
  49. Manickum, T., & John, W. (2014). Occurrence, fate and environmental risk assessment of endocrine disrupting compounds at the wastewater treatment works in Pietermaritzburg (South Africa). Science of the Total Environment, 468-469, 584–597.CrossRefGoogle Scholar
  50. Manickum, T., & John, W. (2015). The current preference for the immune-analytical ELISA method for quantification of steroid hormones (endocrine-disruptor compounds) in wastewater in South Africa. Analytical and Bioanalytical Chemistry, 407, 4949–4970.CrossRefGoogle Scholar
  51. Martin, J., Camacho-Munoz, D., Santos, J. L., Aparicio, I., & Alonso, E. (2012). Occurrence of pharmaceutical compounds in wastewater and sludge from wastewater treatment plants: removal and exotoxicological impact of wastewater discharges and sludge disposal. Journal of Hazardous Materials, 239-240, 40–47.CrossRefGoogle Scholar
  52. McAdam, E. J., Bagnall, J. P., Koh, Y. K. K., Chiu, T. Y., Pollard, S., Scrimshaw, M. D., Lester, J. N., & Cartmell, E. (2010). Removal of steroid estrogens in carbonaceous and nitrifying activated sludge processes. Chemosphere, 81, 1–6.CrossRefGoogle Scholar
  53. Mes, T., Zeeman, G., & Lettinga, G. (2005). Occurrence and fate of estrone, 17β-estradiol and 17α-ethinylestradiol in STPs for domestic wastewater. Environmental Science and Technology, 4, 275–311.Google Scholar
  54. Mittal, A. (2011). Biological wastewater treatment. Water Today, 32–44.Google Scholar
  55. Mnif, W., Dagnino, S., Escande, A., Pillon, A., Fenet, H., Gomez, E., Casellas, C., Duchesne, M. J., Hernandez-Raquet, G., Cavailles, V., Balaguer, P., & Bartegi, A. (2010). Biological analysis of endocrine disrupting compounds in Tunisian sewage treatment plants. Archives of Environmental Contamination and Toxicology, 59, 1–2.CrossRefGoogle Scholar
  56. Mohagheghian, A., Nabizadeh, R., Mesdghinia, A., Rastkari, N., Mahvi, A. H., Alimohammadi, M., Yunesian, M., Ahmadkhaniha, R., & Nazmara, S. (2014). Distribution of estrogenic steroids in municipal wastewater treatment plants in Tehran, Iran. Journal of Environmental Health Science and Engineering, 12, 97.CrossRefGoogle Scholar
  57. Muz, M., Sonmez, M. S., Komesli, O. T., Barirdere, S., & Gokcay, C. F. (2012). Determination of selected natural hormones and endocrine disrupting compounds in domestic wastewater treatment plants by liquid chromatography electrospray ionization tandem mass spectrometry after solid phase extraction. Analyst, 137, 884.CrossRefGoogle Scholar
  58. Nelson, J., Bishay, F., Roodselaar, A., Ikonomou, M., & Law, F. C. P. (2007). The use of in vitro bioassays to quantify endocrine disrupting chemicals in municipal wastewater treatment plant effluents. Science of the Total Environment, 374, 80–90.CrossRefGoogle Scholar
  59. Noppe, H., Bizec, B. L., Verheyden, K., & Brabander, H. F. (2008). Novel analytical methods for the determination of steroid hormones in edible matrices. Analytica Chimica Acta, 611, 1–16.CrossRefGoogle Scholar
  60. Pal, A., Gin, K. Y. H., Lin, A. Y. C., & Reinhard, M. (2010). Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects. Science of the Total Environment, 408, 6062–6069.CrossRefGoogle Scholar
  61. Pereira, R. O., Postigo, C., Alda, M. L., Daniel, L. A., & Barcelo, D. (2011). Removal of estrogens through water disinfection processes and formation of by-products. Chemosphere, 82, 789–799.CrossRefGoogle Scholar
  62. Pessoa, G., Souza, N. D., Vidal, C., Alves, J. A. C., Firmino, P. I. M., Nascimento, R. F., & Santos, A. B. D. (2014). Occurrence and removal of estrogens in Brazilian wastewater treatment plants. Science of the Total Environment, 490, 288–295.CrossRefGoogle Scholar
  63. Ra, J. S., Lee, S. H., Lee, J., Kim, H. Y., Lim, B. J., Kim, S. H., & Kim, S. D. (2011). Occurrence of estrogenic chemicals in South Korea surface waters and municipal wastewaters. Journal of Environmental Monitoring, 13, 101.CrossRefGoogle Scholar
  64. Racz, L. A., & Goel, R. K. (2009). Fate and removal of estrogens in municipal wastewater. Journal of Environmental Monitoring, 12, 58–70.CrossRefGoogle Scholar
  65. Ren, Y. X., Nakano, K., Nomura, M., Chiba, N., & Nishimura, O. (2007). Effects of bacterial activity on estrogen removal in nitrifying activated sludge. Water Research, 41, 3089–3096.CrossRefGoogle Scholar
  66. Sarmah, A. K., Northcott, G. L., Leusch, F. D. L., & Tremblay, L. A. (2006). A survey of endocrine disrupting chemicals (EDCs) in municipal sewage and animal waste effluents in the Waikato region of New Zealand. Science of the Total. Environment, 355, 135–144.CrossRefGoogle Scholar
  67. Servos, M. R., Bennie, D. T., Burnison, B. K., Jurkovic, A., Mclnnis, R., Neheli, T., Schnell, A., Seto, P., Smyth, S. A., & Ternes, T. A. (2005). Distribution of estrogens, 17β-estradiol and estrone, in Canadian municipal wastewater treatment plants. Science of the Total Environment, 336, 155–170.CrossRefGoogle Scholar
  68. Silva, C. P., Otero, M., & Esteves, V. (2012). Process for the elimination of estrogenic steroid hormones from water: a review. Environmental Pollution, 165, 38–58.CrossRefGoogle Scholar
  69. Sim, W. J., Lee, J. W., Shin, S. K., Song, K. B., & Oh, J. E. (2011). Assessment of fates of estrogens in wastewater and sludge from various types of wastewater treatment plants. Chemosphere, 82, 1448–1453.CrossRefGoogle Scholar
  70. Soto, A. M., Calabro, J. M., Prechtl, N. V., Yau, A. Y., Orlando, E. F., Daxenberger, A., Kolok, A. S., Guillete, L. J., Bizec, B., Lange, I. G., & Sonnenschein, C. (2004). Androgenic and estrogenic activity in water bodies receiving cattle feedlot effluent in Eastern Nebraska, USA. Environmental Health Perspectives, 112(3), 346–352.CrossRefGoogle Scholar
  71. Spellman, F.R. (1999). Spellman’s standard handbooks for wastewater operators. 1.Google Scholar
  72. Sperling, M. (2006). Wastewater characteristics, treatment and disposal. Biological Wastewater Treatment Series. 1.Google Scholar
  73. Surujlal-Naicker, S., & Bux, F. (2013). Application of radio-immunoassays to assess the fate of estrogen EDCs in full scale wastewater treatment plants. Journal of Environmental Science and Health, 48, 37–47.CrossRefGoogle Scholar
  74. Svenson, A., Allard, A. S., & Ek, M. (2003). Removal of estrogenicity in Swedish municipal sewage treatment plants. Water Research, 37, 4433–4443.CrossRefGoogle Scholar
  75. Swart, N., & Pool, E. (2007). Rapid detection of selected steroid hormones from sewage effluents using an ELISA in Kuils River water catchment area, South Africa. Journal of Immunoassay and Immunochemistry, 28(4), 395–408.CrossRefGoogle Scholar
  76. Tan, B. L. L., Hawker, D. W., Muller, J. F., Leusch, F. D. L., Tremblay, L. A., & Chapman, H. F. (2007). Comprehensive study of endocrine disrupting compounds using grab and passive sampling at selected wastewater treatment plants in South East Queensland, Australia. Environment International, 33, 654–669.CrossRefGoogle Scholar
  77. Ternes, T. A., Kreckel, P., & Mueller, J. (1999). Behaviour and occurrence of estrogens in municipal sewage treatment plants—II. Aerobic batch experiments with activated sludge. Science of the Total Environment, 225, 91–99.Google Scholar
  78. Xu, N., Xu, Y. F., Xu, S., Li, J., & Tao, H. C. (2012). Removal of estrogens in municipal wastewater treatment plants: a Chinese perspective. Environmental Pollution, 165, 215–224.CrossRefGoogle Scholar
  79. Yang, M., Wang, K., Shen, Y., & Wu, M. (2011). Evaluation of estrogenic activity in surface water and municipal wastewater in Shanghai, China. Bulletin of Environmental Contamination and Toxicology, 87, 215–219.CrossRefGoogle Scholar
  80. Ye, X., Guo, X., Cui, X., Zhang, X., Zhang, H., Wang, M. K., Qiu, L., & Chen, S. (2012). Occurrence and removal of endocrine disrupting chemicals in wastewater treatment plants in the Three Gorges Reservoir area, Chongqing, China. Journal of Environmental Monitoring, 14, 2204.CrossRefGoogle Scholar
  81. Ying, G. G., Kookana, R. S., & Ru, Y. J. (2002). Occurrence and fate of hormone steroids in the environment. Environmental International, 28, 545–551.CrossRefGoogle Scholar
  82. Yu, C. P., Deeb, R. A., & Chu, K. H. (2013). Microbial degradation of steroidal estrogens. Chemosphere, 9, 1225–1235.CrossRefGoogle Scholar
  83. Zeng, Q. L., Li, Y. M., Gu, G. W., Zhao, J. M., Zhang, C. J., & Luan, J. F. (2008). Sorption and biodegradation of 17β-estradiol by acclimated aerobic activated sludge and isolation of the bacterial strain. Environmental Engineering Science, 26(4), 783–790.CrossRefGoogle Scholar
  84. Zhang, Z., Feng, Y., Gao, P., Wang, C., & Ren, N. (2011). Occurrence and removal efficiencies of eight EDCs and estrogenicity in a STP. Journal of Environmental Monitoring, 13, 1366.CrossRefGoogle Scholar
  85. Zhang, Y., & Zhou, J. L. (2008). Occurrence and removal of endocrine disrupting chemicals in wastewater. Chemosphere, 73, 848–853.CrossRefGoogle Scholar
  86. Zhou, Y., Zha, J., Xu, Y., Lei, B., & Wang, Z. (2012). Occurrence of six steroid estrogens from different effluents in Beijing, China. Environmental Monitoring Assessment, 184, 1719–1729.CrossRefGoogle Scholar
  87. Zorita, S., Martensson, L., & Mathiasson, L. (2009). Occurrence and removal of pharmaceuticals in a municipal sewage treatment system in the south of Sweden. Science of the Total Environment, 407, 2760–2770.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of Environmental and Occupational Health, Faculty Of Medicine and Health SciencesUniversiti Putra Malaysia (UPM)SerdangMalaysia

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