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Determination of urinary levels of Bisphenol A in a Turkish population

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Abstract

Bisphenol A (BPA) is one of the environmental endocrine disrupting chemicals that is widely used in common consumer products. The aim of this study was to report the total urinary BPA concentrations (free plus conjugated) in 200 urine samples (children: 57; male: 74; female: 69) obtained from residents of a Mediterranean city, Mersin. Analyses were performed by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and for assessing environmental exposure to free BPA and its major metabolite bisphenol A glucuronide (BPAG) in human urine were determinated. Our results indicated that the free BPA and BPAG concentrations were in the range of 0.06-0.99 μg/g creatinine and 0.24-615 μg/g creatinine, respectively. No statistically significant difference obtained in BPA concentrations between genders (male and female) or domicile of residence (rural and urban) (p > 0.05). In our study, the mean level of detected free BPA was 0.46 μg/g creatinine in the urban area and 0.37 μg/g creatinine in the rural area. The average amount of BPAG was 60.56 μg/g creatinine in the urban area and 30.28 μg/g creatinine in the rural area. The data demonstrate that determined amount of total BPA in the present study is lower than the results of similar studies conducted in developed countries. There is no data about the levels of BPA in humans and environment in Turkey. Because of this reason, present study is very important since it is the first study in Turkey which determined the concentrations of free BPA and total BPA in human.

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Acknowledgements

This work was supported by Mersin University, Department of Scientific Research Projects [Grant number: BAP-SBE FT (DB) 2011–7 YL].

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The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Toxicology, Mersin University, 33169, Mersin, Turkey

    Dilek Battal & Ayca Aktas

  2. Faculty of Pharmacy, Department of Toxicology, Gazi University, 06330, Ankara, Turkey

    Ismet Cok

  3. Acibadem Lab Med Research and Development Laboratory, 34662, Istanbul, Turkey

    Irfan Unlusayin

  4. Faculty of Pharmacy, Department of Pharmacology, Mersin University, 33169, Mersin, Turkey

    Bahar Tunctan

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  1. Dilek Battal
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  2. Ismet Cok
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Correspondence to Dilek Battal.

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Battal, D., Cok, I., Unlusayin, I. et al. Determination of urinary levels of Bisphenol A in a Turkish population. Environ Monit Assess 186, 8443–8452 (2014). https://doi.org/10.1007/s10661-014-4015-z

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