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Mutagenic activity of river water from a river near textile industrial complex in Korea

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Abstract

The mutagenic activity of XAD-2 adsorbates and water extracts recovered from nine locations of the Kumho River was tested on S. typhimurium TA98 strain to identify the source of the mutagenicity. A sampling site, receiving effluents from the textile industrial complex located in Daegu City, showed extraordinarily high mutagenic activity, especially in the presence of S9 mixture, at all sampling time in both XAD-2 adsorbates and dichloromethane extracts. This indicated the existence of the frame-shift mutagens in the Kumho River, same type of mutagens detected in previous studies by other researchers in the Nakdong River into which the Kumho River discharges. The fractionation study showed that the mutagenic chemicals in the river water are mid-polar. Furthermore, mean tail length obtained by single cell gel electrophoresis assay (Comet assay) showed consistent dose-dependent DNA damage, indicating that the chemicals in the river water not only act as frame-shift mutagens but also break human lymphocytes DNA strain. Chemical identification of the mutagens should be required.

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Author notes

  1. Jung-Hwan Kwon

    Present address: Department of Environmental Engineering, Ajou University, Wonchun-dong, Yeongtong-gu, Suwon, 443-749, South Korea

Authors and Affiliations

  1. Department of Environmental Toxicology (UTOX), Swiss Federal Institute of Aquatic Science and Technology (EAWAG), Überlandstrasse 133, P.O. Box 611, 8600, Dübendorf, Switzerland

    Jung-Hwan Kwon

  2. Chemon Inc., 334 Jeilri, Yangjimyeon, Yongin, Gyeonggido, 449-826, South Korea

    Hyun-Kul Lee

  3. National Veterinary Research and Quarantine Service Pusan Regional Office 620-2, Amnam-dong, Seo-gu, Pusan, 602-030, South Korea

    Jin-Wook Kwon

  4. Analytical Research Center, Korea Institute of Toxicology (KITOX), P.O. Box 107, Yusong, Daejeon, 305-600, South Korea

    Kyun Kim

  5. Department of Environmental Toxicology, Korea Institute of Toxicology (KITOX), P.O. Box 107, Yusong, Daejeon, 305-600, South Korea

    Yong-Hwa Kim

  6. Department of Life Science, Kyungnam University, 449 Wolyoung-dong, Masan, 631-701, South Korea

    Eunju Park

  7. Department of Food and Nutrition, Hannam University, 133 Ojeong-dong, Daedeok-gu, Daejeon, 306-791, South Korea

    Myung-Hee Kang

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  1. Jung-Hwan Kwon
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  2. Hyun-Kul Lee
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Correspondence to Jung-Hwan Kwon.

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Kwon, JH., Lee, HK., Kwon, JW. et al. Mutagenic activity of river water from a river near textile industrial complex in Korea. Environ Monit Assess 142, 289–296 (2008). https://doi.org/10.1007/s10661-007-9928-3

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  • DOI: https://doi.org/10.1007/s10661-007-9928-3

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