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Sampling and Analysis of Quaternary Ammonium Compounds (QACs) Traces in Indoor Atmosphere

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Abstract

Quaternary Ammonium Compounds (QACs) are widely found in disinfectants used in hospitals. Benzalkonium chloride (BAC) and didecyldimethylammonium chloride (DDAC) predominate in the disinfecting formulations. These compounds are strong irritants and can play a role in the induction of Occupational Asthma among the professionals of health and cleaning. In order to evaluate the potential health effect of these quaternary ammonium compounds to hospital employers, the development of an analytical method for their quantification in indoor air was developed. DDAC aerosols are trapped by adsorption on XAD-2 resin SKC® tube. The air in hospital buildings was sampled using a constant debit Gillian® pump at a flow of 1.0 l/min (±5%). Ion Chromatography (IC) was chosen for the analysis of DDAC especially for its high sensitivity and specificity. The Limit of Detection (LOD) by IC for DDAC is 0.56 μg/ml. Therefore the LOD of atmospheric DDAC is 28 μg/m3 with an air volume of 100 l and a desorption volume of 5 ml. All DDAC air samples were lower than the LOD of the analytical method by IC. Under the standard conditions of use of the disinfecting solutions (Surfanios®, Ampholysine Plus® and Amphospray 41®), the insignificant volatility of DDAC would not seem to be able to contaminate the indoor hospital atmosphere during the disinfection process. However, the DDAC can contaminate working atmospheres if it is put in suspension by aerosolisation.

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Authors and Affiliations

  1. Laboratoire de Physico-Chimie de l’Atmosphère, Centre de Géochimie de la Surface, UMR 7517 CNRS – Université Louis Pasteur, 1, rue Blessig, 67084, Strasbourg Cedex, France

    Guillaume Vincent, Philippe Mirabel & Maurice Millet

  2. Hôpitaux Universitaires de Strasbourg – Service de Pneumologie, 1 rue des Canonniers, 67000, Strasbourg, France

    Marie Christine Kopferschmitt-Kubler & Gabrielle Pauli

Authors
  1. Guillaume Vincent
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  2. Marie Christine Kopferschmitt-Kubler
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  3. Philippe Mirabel
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  4. Gabrielle Pauli
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  5. Maurice Millet
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Correspondence to Maurice Millet.

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Vincent, G., Kopferschmitt-Kubler, M.C., Mirabel, P. et al. Sampling and Analysis of Quaternary Ammonium Compounds (QACs) Traces in Indoor Atmosphere. Environ Monit Assess 133, 25–30 (2007). https://doi.org/10.1007/s10661-006-9556-3

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  • DOI: https://doi.org/10.1007/s10661-006-9556-3

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