European Journal of Plant Pathology

, Volume 152, Issue 4, pp 993–1001 | Cite as

Bioinformatics tools for the discovery of new lipopeptides with biocontrol applications

  • M. Pupin
  • A. Flissi
  • P. Jacques
  • Valérie LeclèreEmail author
SI: Plant Pathology for Innovative Agroecology


As conventional or chemical pesticides have negative impact on environment and health of both farmer and consumers, it becomes relevant to develop alternative solutions to limit their use. In this context, innovative strategies to accelerate the development of biocontrol agents are welcome. For a decade of years, it has been demonstrated that lipopeptides are very efficient weapons against fungi responsible for crop diseases. Lipopeptides are secondary metabolites, produced by many microorganisms including beneficial rhizobacteria. The lipopeptide biosynthetic pathways include nonribosomal peptide synthetases. These modular enzymatic complexes work as assembly lines to build the peptides step by step, leading to the production of original peptide compounds with specific features as the presence of non proteinogenic monomers and cyclic and branched structures. In this paper, Florine and Norine bioinformatics tools, especially dedicated to non-ribosomal synthetases and their products are presented. Their use is mainly focused on the discovery of lipopeptides produced by Bacillus or Pseudomonas because they seem to represent a versatile reservoir of active secondary metabolites with promising activities for applications in phytosanitary area.


NRPS Lipopeptide Biocontrol Bioinformatics Norine 



This work has been carried out in the framework of Alibiotech project which is financed by European Union, French State and the French Region of Hauts-de-France. Authors would like to thank European Union funding through the INTERREG V France-Wallonie-Vlaanderen Project SmartBioControl/BioScreen and the bioinformatics platform bilille.

Compliance with ethical standards

Conflict of interest

No Disclosure of potential conflicts of interest.

Human and animal rights

No Research involving Human Participants and/or Animals.

Informed consent



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Copyright information

© Koninklijke Nederlandse Planteziektenkundige Vereniging 2018

Authors and Affiliations

  • M. Pupin
    • 1
    • 2
  • A. Flissi
    • 1
    • 2
  • P. Jacques
    • 3
  • Valérie Leclère
    • 4
    Email author
  1. 1.Univ. Lille, CNRS, Centrale Lille, UMR 9189 - CRIStAL - Centre de Recherche en Informatique Signal et Automatique de LilleLilleFrance
  2. 2.Inria-Lille Nord Europe, Bonsai TeamVilleneuve d’Ascq CedexFrance
  3. 3.TERRA Research Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech University of LiegeGemblouxBelgium
  4. 4.Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral Côte d’Opale, EA 7394-ICV- Institut Charles ViolletteLilleFrance

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