The aim of our study was to assess the association between green tea consumption and all-cause and cause-specific mortality in a pooled analysis of eight Japanese population-based cohort studies. Pooled hazard ratios (HR) and 95% confidence intervals (CI), derived from random effects models, were used to evaluate the associations between green tea consumption, based on self-report at baseline, and risk of all-cause and cause-specific mortality. During a mean follow-up of 17.3 years, among 313,381 persons, 52,943 deaths occurred. Compared with individuals who consumed < 1 cup/day, those in the highest consumption category (≥ 5 cups/day) had a decreased risk of all-cause mortality [the multivariate-adjusted HR was 0.90 (95% CI 0.87–0.94) for men and 0.82 (0.74–0.90) for women]. A similar inverse association was observed for heart disease mortality [HR 0.82 (0.75–0.90) for men, and 0.75 (0.68–0.84) for women], and cerebrovascular disease mortality [HR 0.76 (0.68–0.85) for men, and 0.78 (0.68–0.89) for women]. Among women, green tea consumption was associated with decreased risk of total cancer mortality: 0.89 (0.83–0.96) for the 1–2 cups/day category and 0.91 (0.85–0.98) for the 3–4 cups/day category. Results for respiratory disease mortality were [HR 0.75 (0.61–0.94)] among 3–4 cup daily consumers and [HR 0.66 (0.55–0.79)] for ≥ 5 cups/day. Higher consumption of green tea is associated with lower risk for all-cause mortality in Japanese, especially for heart and cerebrovascular disease. Moderate consumption decreased the risk of total cancer and respiratory disease mortality in women.
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The Japan Public Health Center-based Prospective Study, Cohort I
The Japan Public Health Center-based Prospective Study, Cohort II
The Japan Collaborative Cohort Study
The Miyagi Cohort Study
The Ohsaki National Health Insurance Cohort Study
- 3-pref MIYAGI:
The Three Prefecture Study—Miyagi portion
- 3-pref AICHI:
The Three Prefecture Study—Aichi portion
- 3-pref OSAKA:
The Three Prefecture Study—Osaka portion
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This study was supported by the National Cancer Center Research and Development Funds (30-A-15, 27-A-4, 24-A-3) and the Health and Labour Sciences Research Grants for the Third Term Comprehensive Control Research for Cancer (H21-3jigan-ippan-003, H18-3jigan-ippan-001, H16-3jigan-010). The funders had no role in the design, data collection, analysis, interpretation or manuscript drafting, or in the decision to submit the manuscript for publication.
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For the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan: Research group members are listed at the following site (as of August 2018): http://epi.ncc.go.jp/en/can_prev/796/7955.html.
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Abe, S.K., Saito, E., Sawada, N. et al. Green tea consumption and mortality in Japanese men and women: a pooled analysis of eight population-based cohort studies in Japan. Eur J Epidemiol 34, 917–926 (2019). https://doi.org/10.1007/s10654-019-00545-y
- Green tea
- Cohort study
- Pooled analysis