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European Journal of Epidemiology

, Volume 32, Issue 12, pp 1065–1073 | Cite as

Prenatal exposure to Chernobyl fallout in Norway: neurological and developmental outcomes in a 25-year follow-up

  • Rolv Terje LieEmail author
  • Dag Moster
  • Per Strand
  • Allen James Wilcox
PERINATAL EPIDEMIOLOGY

Abstract

Ionizing radiation at high doses early in life may cause neurodevelopmental problems. Possible effects of lower doses are, however, controversial. We use carefully collected exposure data for Norway following the Chernobyl accident in April 1986 combined with population-based registries to assess long-term effects of fetal exposure on neurodevelopmental outcomes. Radiation doses were estimated for each Norwegian municipality for each calendar month from May 1986 to April 1989. We established a cohort of all Norwegian pregnancies during the three-year period of radiation measurement and compared them with appropriate unexposed groups. All cohorts were followed into adulthood. Risks of cerebral palsy, mental retardation, schizophrenia, epilepsy, vision or hearing problems, school dropout, and low income were estimated. We also conducted an analysis of mathematics and language grades using siblings born after the exposure period as comparison. There was little evidence of associations between radiation exposure and cerebral palsy, mental retardation, schizophrenia, epilepsy, or hearing or vision problems associated with radiation exposure. (p-values for trend with exposure dose were 0.27, 0.14, 0.83, 0.35 and 0.42.) Slightly more of the exposed failed to complete high school (p = 0.05), but there was no increase in the proportion with low income (p = 0.38). The natural advantage of older siblings over younger siblings in mathematics grades was diminished with exposure of older siblings (p = 0.003), but there was no association of exposure with Norwegian language grades (p = 0.37). There is scant evidence that the low-dose fallout from Chernobyl in Norway increased the risk for serious neurodevelopmental problems. We cannot exclude the possibility of lower mathematics grades with exposure, similar to a report from Sweden.

Keywords

Chernobyl Radiation Prenatal Neurological Developmental Pregnancy Long-term follow-up 

Notes

Acknowledgements

This research was supported in part by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences and by travel grants from Meltzer’s Hoyskolefond and Faculty of Medicine, University of Bergen. We thank Dr Maureen Hatch, Dr Walter Rogan, and Dr Clarice Weinberg for valuable comments on the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Supplementary material

10654_2017_350_MOESM1_ESM.pdf (305 kb)
Supplementary Fig. 1 Distribution of 168,644 Norwegian children by the measured radiation exposure in their municipality at the child’s 5th month of gestation, May 1986 to April 1989 (PDF 306 kb)
10654_2017_350_MOESM2_ESM.pdf (224 kb)
Supplementary Fig. 2a Follow-up of persons in the exposed group and the reference group. Supplementary Fig. 2b Follow-up of persons from the exposure period and their younger siblings(PDF 225 kb)
10654_2017_350_MOESM3_ESM.pdf (378 kb)
Supplementary Fig. 3 Association between exposure in month 2, 8, 12, 15 and 18 (counting month of LMP as month 1) for the neurodevelopmental outcomes. None of the trends tests had p-values below 0.14 (PDF 379 kb)
10654_2017_350_MOESM4_ESM.docx (16 kb)
Supplementary material 4 (DOCX 16 kb)
10654_2017_350_MOESM5_ESM.docx (19 kb)
Supplementary material 5 (DOCX 19 kb)

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Rolv Terje Lie
    • 1
    • 2
    Email author
  • Dag Moster
    • 1
    • 3
  • Per Strand
    • 4
    • 5
  • Allen James Wilcox
    • 6
  1. 1.Department of Global Public Health and Primary CareUniversity of BergenBergenNorway
  2. 2.Centre for Fertility and Health, Norwegian Institute of Public HealthOsloNorway
  3. 3.Department of PediatricsHaukeland University HospitalBergenNorway
  4. 4.Norwegian Radiation Protection AuthorityOsloNorway
  5. 5.Faculty of Environmental Sciences and Natural Resource ManagementNorwegian University of Life SciencesÅsNorway
  6. 6.National Institute of Environmental Health Sciences, NIHDurhamUSA

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