Skip to main content

Advertisement

SpringerLink
Log in

Ophthalmic epidemiology in Europe: the “European Eye Epidemiology” (E3) consortium

  • NEW STUDY
  • Published:
European Journal of Epidemiology Aims and scope Submit manuscript

Abstract

The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case–control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The aim of the consortium is to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe, with particular focus on the harmonization of methods for future research, estimation and projection of frequency and impact of visual outcomes in European populations (including temporal trends and European subregions), identification of risk factors and pathways for eye diseases (lifestyle, vascular and metabolic factors, genetics, epigenetics and biomarkers) and development and validation of prediction models for eye diseases. Coordinating these existing data will allow a detailed study of the risk factors and consequences of eye diseases and visual impairment, including study of international geographical variation which is not possible in individual studies. It is expected that collaborative work on these existing data will provide additional knowledge, despite the fact that the risk factors and the methods for collecting them differ somewhat among the participating studies. Most studies also include biobanks of various biological samples, which will enable identification of biomarkers to detect and predict occurrence and progression of eye diseases. This article outlines the rationale of the consortium, its design and presents a summary of the methodology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. McKean-Cowdin R, Varma R, Hays RD, et al. Longitudinal changes in visual acuity and health-related quality of life: the Los Angeles Latino Eye study. Ophthalmology. 2010;117:1900–7 (7 e1).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Seland JH, Vingerling JR, Augood CA, et al. Visual impairment and quality of life in the older European population, the EUREYE study. Acta Ophthalmol. 2011;89:608–13.

    Article  PubMed  Google Scholar 

  3. Lam BL, Christ SL, Zheng DD, et al. longitudinal relationships among visual acuity and tasks of everyday life: the Salisbury Eye Evaluation study. Invest Ophthalmol Vis Sci. 2013;54:193–200.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Daien V, Peres K, Villain M, et al. Visual acuity thresholds associated with activity limitations in the elderly. The Pathologies Oculaires Liees a l’Age study. Acta Ophthalmol. 2014;92:e500–6.

    Article  PubMed  Google Scholar 

  5. Carriere I, Delcourt C, Daien V, et al. A prospective study of the bi-directional association between vision loss and depression in the elderly. J Affect Disord. 2013;151:164–70.

    Article  PubMed  Google Scholar 

  6. Lamoureux EL, Fenwick E, Moore K, et al. Impact of the severity of distance and near-vision impairment on depression and vision-specific quality of life in older people living in residential care. Invest Ophthalmol Vis Sci. 2009;50:4103–9.

    Article  PubMed  Google Scholar 

  7. Patino CM, McKean-Cowdin R, Azen SP, et al. Central and peripheral visual impairment and the risk of falls and falls with injury. Ophthalmology. 2010;117(199–206):e1.

    PubMed  Google Scholar 

  8. Yip JL, Khawaja AP, Broadway D, et al. Visual acuity, self-reported vision and falls in the EPIC-Norfolk Eye study. Br J Ophthalmol. 2014;98:377–82.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Gordois A, Cutler H, Pezzullo L, et al. An estimation of the worldwide economic and health burden of visual impairment. Glob Public Health. 2012;7:465–81.

    Article  PubMed  Google Scholar 

  10. Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96:614–8.

    Article  PubMed  Google Scholar 

  11. He M, Abdou A, Naidoo KS, et al. Prevalence and correction of near vision impairment at seven sites in China, India, Nepal, Niger, South Africa, and the United States. Am J Ophthalmol. 2012;154(107–16):e1.

    PubMed  Google Scholar 

  12. World Health Organization. Action plan for the prevention of avoidable blindness and vision impairment, 2009–2013. 2010.

  13. World Health Organization. Universal eye health: a global action plan 2014–2019. 2013.

  14. Drexler W, Fujimoto JG. State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res. 2008;27:45–88.

    Article  PubMed  Google Scholar 

  15. Asbell PA, Dualan I, Mindel J, et al. Age-related cataract. Lancet. 2005;365:599–609.

    Article  PubMed  Google Scholar 

  16. Leske MC, Chylack LT, He QM, et al. Risk factors for nuclear opalescence in a longitudinal study. Am J Epidemiol. 1998;147:36–41.

    Article  CAS  PubMed  Google Scholar 

  17. Delcourt C, Cristol JP, Tessier F, et al. Risk factors for cortical, nuclear, and posterior subcapsular cataracts: the POLA study. Pathologies Oculaires Liees a l’Age. Am J Epidemiol. 2000;151:497–504.

    Article  CAS  PubMed  Google Scholar 

  18. Christen WG, Glynn RJ, Ajani UA, et al. Smoking cessation and risk of age-related cataract in men. JAMA. 2000;284:713–6.

    Article  CAS  PubMed  Google Scholar 

  19. Prokofyeva E, Wegener A, Zrenner E. Cataract prevalence and prevention in Europe: a literature review. Acta Ophthalmol. 2013;91:395–405.

    Article  PubMed  Google Scholar 

  20. Vingerling JR, Hofman A, Grobbee DE, De Jong PT. Age-related macular degeneration and smoking. The Rotterdam Study. Arch Ophthalmol. 1996;114:1193–6.

    Article  CAS  PubMed  Google Scholar 

  21. Delcourt C, Diaz JL, Ponton-Sanchez A, Papoz L. Smoking and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liees a l’Age. Arch Ophthalmol. 1998;116:1031–5.

    Article  CAS  PubMed  Google Scholar 

  22. Smith W, Assink J, Klein R, et al. Risk factors for age-related macular degeneration: pooled findings from three continents. Ophthalmology. 2001;108:697–704.

    Article  CAS  PubMed  Google Scholar 

  23. Chakravarthy U, Augood C, Bentham GC, et al. Cigarette smoking and age-related macular degeneration in the EUREYE Study. Ophthalmology. 2007;114:1157–63.

    Article  CAS  PubMed  Google Scholar 

  24. Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY. Age-related macular degeneration. Lancet. 2012;379:1728–38.

    Article  PubMed  Google Scholar 

  25. Erke MG, Bertelsen G, Peto T, et al. Cardiovascular risk factors associated with age-related macular degeneration: the Tromso Study. Acta Ophthalmol. 2014;92:662–9.

    Article  PubMed  Google Scholar 

  26. Klein R, Klein BE, Moss SE, Meuer SM. The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study. Trans Am Ophthalmol Soc. 2000;98:133–41 (discussion 41–3).

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Cruickshanks KJ, Klein BE, Klein R. Ultraviolet light exposure and lens opacities: the Beaver Dam Eye Study. Am J Public Health. 1992;82:1658–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. West SK, Duncan DD, Munoz B, et al. Sunlight exposure and risk of lens opacities in a population-based study: the Salisbury Eye Evaluation Project. JAMA. 1998;280:714–8.

    Article  CAS  PubMed  Google Scholar 

  29. Delcourt C, Carriere I, Ponton Sanchez A, et al. Light exposure and the risk of cortical, nuclear, and posterior subcapsular cataracts: the Pathologies Oculaires Liées à l’Age (POLA) Study. Arch Ophthalmol. 2000;118:385–92.

    Article  CAS  PubMed  Google Scholar 

  30. McCarty CA, Taylor HR. A review of the epidemiologic evidence linking ultraviolet radiation and cataracts. Dev Ophthalmol. 2002;35:21–31.

    Article  PubMed  Google Scholar 

  31. Delcourt C, Cougnard-Gregroire A, Boniol M, et al. Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration: the Alienor Study. Invest Ophthalmol Vis Sci. 2014;55:7619–27.

  32. Threlfall TJ, English DR. Sun exposure and pterygium of the eye: a dose-response curve. Am J Ophthalmol. 1999;128:280–7.

    Article  CAS  PubMed  Google Scholar 

  33. McCarty CA, Fu CL, Taylor HR. Epidemiology of pterygium in Victoria, Australia. Br J Ophthalmol. 2000;84:289–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Fletcher AE, Bentham GC, Agnew M, et al. Sunlight exposure, antioxidants, and age-related macular degeneration. Arch Ophthalmol. 2008;126:1396–403.

    Article  PubMed  Google Scholar 

  35. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case–Control Study Group JAMA. 1994;272:1413–20.

    CAS  PubMed  Google Scholar 

  36. Delcourt C, Cristol JP, Tessier F, et al. Age-related macular degeneration and antioxidant status in the POLA study. POLA Study Group. Pathologies Oculaires Liees a l’Age. Arch Ophthalmol. 1999;117:1384–90.

    Article  CAS  PubMed  Google Scholar 

  37. van Leeuwen R, Boekhoorn S, Vingerling JR, et al. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA. 2005;294:3101–7.

    Article  PubMed  Google Scholar 

  38. Tan JS, Wang JJ, Flood V, et al. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology. 2008;115:334–41.

    Article  PubMed  Google Scholar 

  39. Mares Perlman JA, Fisher AI, Klein R, et al. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am J Epidemiol. 2001;153:424–32.

    Article  CAS  PubMed  Google Scholar 

  40. Delcourt C, Carriere I, Delage M, Barberger-Gateau P, Schalch W. Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study. Invest Ophthalmol Vis Sci. 2006;47:2329–35.

    Article  PubMed  Google Scholar 

  41. Ho L, van Leeuwen R, Witteman JC, et al. Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study. Arch Ophthalmol. 2011;129:758–66.

    Article  CAS  PubMed  Google Scholar 

  42. Lyle BJ, Maresperlman JA, Klein BEK, Klein R, Greger JL. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. Am J Epidemiol. 1999;149:801–9.

    Article  CAS  PubMed  Google Scholar 

  43. Gale CR, Hall NF, Phillips DI, Martyn CN. Plasma antioxidant vitamins and carotenoids and age-related cataract. Ophthalmology. 2001;108:1992–8.

    Article  CAS  PubMed  Google Scholar 

  44. Christen WG, Liu S, Glynn RJ, Gaziano JM, Buring JE. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study. Arch Ophthalmol. 2008;126:102–9.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Fletcher AE. Free radicals, antioxidants and eye diseases: evidence from epidemiological studies on cataract and age-related macular degeneration. Ophthalmic Res. 2010;44:191–8.

    Article  CAS  PubMed  Google Scholar 

  46. AREDS. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch. Arch Ophthalmol. 2001;119:1417–36.

    Article  Google Scholar 

  47. Smith W, Mitchell P, Leeder SR. Dietary fat and fish intake and age-related maculopathy. Arch Ophthalmol. 2000;118:401–4.

    Article  CAS  PubMed  Google Scholar 

  48. Cho E, Hung S, Willett WC, et al. Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr. 2001;73:209–18.

    CAS  PubMed  Google Scholar 

  49. Seddon JM, Rosner B, Sperduto RD, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol. 2001;119:1191–9.

    Article  CAS  PubMed  Google Scholar 

  50. Delcourt C, Carriere I, Cristol JP, Lacroux A, Gerber M. Dietary fat and the risk of age-related maculopathy: the POLANUT study. Eur J Clin Nutr. 2007;61:1341–4.

    Article  CAS  PubMed  Google Scholar 

  51. SanGiovanni JP, Agron E, Clemons TE, Chew EY. Omega-3 long-chain polyunsaturated fatty acid intake inversely associated with 12-year progression to advanced age-related macular degeneration. Arch Ophthalmol. 2009;127:110–2.

    PubMed  PubMed Central  Google Scholar 

  52. Tan JS, Wang JJ, Flood V, Mitchell P. Dietary Fatty acids and the 10-year incidence of age-related macular degeneration: the blue mountains eye study. Arch Ophthalmol. 2009;127:656–65.

    Article  CAS  PubMed  Google Scholar 

  53. Merle B, Delyfer MN, Korobelnik JF, et al. Dietary omega-3 Fatty acids and the risk for age-related maculopathy: the alienor study. Invest Ophthalmol Vis Sci. 2011;52:6004–11.

    Article  CAS  PubMed  Google Scholar 

  54. Merle BM, Benlian P, Puche N, et al. Circulating omega-3 fatty acids and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;55:2010–9.

    Article  CAS  PubMed  Google Scholar 

  55. Augood C, Chakravarthy U, Young I, et al. Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration. Am J Clin Nutr. 2008;88:398–406.

    CAS  PubMed  Google Scholar 

  56. Chiu CJ, Milton RC, Gensler G, Taylor A. Dietary carbohydrate intake and glycemic index in relation to cortical and nuclear lens opacities in the age-related Eye Disease study. Am J Clin Nutr. 2006;83:1177–84.

    CAS  PubMed  Google Scholar 

  57. Chiu CJ, Robman L, McCarty CA, et al. Dietary carbohydrate in relation to cortical and nuclear lens opacities in the melbourne visual impairment project. Invest Ophthalmol Vis Sci. 2010;51:2897–905.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Mares JA, Voland R, Adler R, et al. Healthy diets and the subsequent prevalence of nuclear cataract in women. Arch Ophthalmol. 2010;128:738–49.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376:124–36.

    Article  PubMed  Google Scholar 

  60. Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2224–60.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Zins M, Bonenfant S, Carton M, et al. The CONSTANCES cohort: an open epidemiological laboratory. BMC Public Health. 2010;10:479.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Fritsche LG, Chen W, Schu M, et al. Seven new loci associated with age-related macular degeneration. Nat Genet. 2013;45:433–9 (9e1-2).

    Article  CAS  PubMed  Google Scholar 

  63. Verhoeven VJ, Hysi PG, Wojciechowski R, et al. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet. 2013;45:314–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Hysi PG, Cheng CY, Springelkamp H, et al. Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Nat Genet. 2014;46:1126–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Buitendijk GH, Rochtchina E, Myers C, et al. Prediction of age-related macular degeneration in the general population: the Three Continent AMD Consortium. Ophthalmology. 2013;120:2644–55.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Bourne RR, Jonas JB, Flaxman SR, et al. Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe: 1990–2010. Br J Ophthalmol. 2014;98:629–38.

    Article  PubMed  Google Scholar 

  67. Williams KM, Verhoeven VJ, Cumberland P, et al. Prevalence of refractive error in Europe: the European Eye Epidemiology (E3) consortium. Eur J Epidemiol. 2015;30:305–15.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Williams KM, Bertelsen G, Cumberland P, et al. Increasing prevalence of Myopia in Europe and the impact of education. Ophthalmology. 2015;122:1489–97.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

The E3 consortium thanks Cécile Delcourt, Jean-François Korobelnik, Marie-Bénédicte Rougier and Marie-Noëlle Delyfer for organizing the meetings in Bordeaux in 2011, 2012 and 2013, Stefano Piermarocchi for organizing the meeting in Rome in 2014 and Chris Hammond, Paul Foster and Tunde Peto for organizing the meeting in London in 2015. These workshops have received financial support from Carl Zeiss Meditec AG, Laboratoires Théa, Novartis and OOgroup.

Author information

Authors and Affiliations

  1. Univ. Bordeaux, ISPED, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France

    Cécile Delcourt & Jean-François Korobelnik

  2. INSERM, Centre INSERM U897-Epidemiologie-Biostatistique, 33000, Bordeaux, France

    Cécile Delcourt & Jean-François Korobelnik

  3. Service d’Ophtalmologie, CHU de Bordeaux, 33000, Bordeaux, France

    Jean-François Korobelnik

  4. Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands

    Gabriëlle H. S. Buitendijk & Caroline C. W. Klaver

  5. NIHR Biomedical Research Centre, Moorfields Eye Hospital, NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK

    Paul J. Foster, Tunde Peto & Jugnoo S. Rahi

  6. Department of Ophthalmology, Department of Twin Research and Genetic Epidemiology, King’s College London, St Thomas’ Hospital, London, SE1 7EH, UK

    Christopher J. Hammond

  7. Department of Ophthalmology, University of Padua, Padua, Italy

    Stefano Piermarocchi

  8. Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Nomdo Jansonius

  9. Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

    Gabriëlle H. S. Buitendijk, Nomdo Jansonius & Caroline C. W. Klaver

  10. Department Ophthalmology, University Medical Center, Mainz, Germany

    Alireza Mirshahi

  11. Centre for Experimental Medicine, Queen’s University of Belfast, Belfast, UK

    Ruth E. Hogg & Usha Chakravarthy

  12. INRA, UMR1324 Centre des Sciences du Goût et de l’Alimentation, 21000, Dijon, France

    Lionel Bretillon & Catherine Creuzot-Garcher

  13. CNRS, UMR6265 Centre des Sciences du Goût et de l’Alimentation, 21000, Dijon, France

    Lionel Bretillon & Catherine Creuzot-Garcher

  14. Université de Bourgogne, Centre des Sciences du Goût et de l’Alimentation, 21000, Dijon, France

    Lionel Bretillon & Catherine Creuzot-Garcher

  15. Laboratory of Research and Clinical Applications in Ophthalmology, Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece

    Fotis Topouzis

  16. Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria

    Gabor Deak

  17. Research Unit of Ophthalmology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

    Jakob Grauslund & Rebecca Broe

  18. Department of Ophthalmology, Odense University Hospital, 5000, Odense, Denmark

    Jakob Grauslund & Rebecca Broe

  19. Service d’ophtalmologie, Centre Hospitalier Intercommunal de Creteil, CRC, CRB, Universite Paris Est, Creteil, France

    Eric H. Souied

  20. Department of Ophthalmology, CHU, 21000, Dijon, France

    Catherine Creuzot-Garcher

  21. Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, Paris, 75012, France

    José Sahel

  22. INSERM, U968, 75012, Paris, France

    José Sahel

  23. CNRS, UMR_7210, 75012, Paris, France

    José Sahel

  24. Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 1423, 75012, Paris, France

    José Sahel

  25. Fondation Ophtalmologique Rothschild, 75019, Paris, France

    José Sahel

  26. Institute of Ophthalmology, University College London, London, EC1V 9EL, UK

    José Sahel

  27. INSERM, U1061, 34093, Montpellier, France

    Vincent Daien

  28. Univ Montpellier 1, 34000, Montpellier, France

    Vincent Daien

  29. Department of Ophthalmology, Gui De Chauliac Hospital, 34000, Montpellier, France

    Vincent Daien

  30. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland

    Terho Lehtimäki

  31. University of Tampere School of Medicine, Tampere, Finland

    Terho Lehtimäki

  32. Clinical Epidemiology, Institute of Epidemiology and Social Medicine, University Münster, 48129, Münster, Germany

    Hans-Werner Hense

  33. INSERM, U1018, Centre for Research in Epidemiology and Population Health (CESP), Epidemiology of Occupational and Social Determinants of Health, Villejuif, France

    Elena Prokofyeva

  34. Université de Versailles Saint-Quentin, Villejuif, France

    Elena Prokofyeva

  35. Northern State Medical University, Arkhangelsk, Russia

    Elena Prokofyeva

  36. Institute of Human Genetics, Technische Universität München, 81675, Munich, Germany

    Konrad Oexle

  37. Population, Policy and Practice Programme, UCL Institute of Child Health, London, WC1N 1EH, UK

    Jugnoo S. Rahi & Phillippa M. Cumberland

  38. Ulverscroft Vision Research Group, UCL Institute of Child Health, London, WC1N 1EH, UK

    Jugnoo S. Rahi & Phillippa M. Cumberland

  39. Department of Ophthalmology, GRADE Reading Center, University of Bonn, 53127, Bonn, Germany

    Steffen Schmitz-Valckenberg

  40. Center of Ophthalmology, University Hospital Cologne, 50924, Cologne, Germany

    Sascha Fauser

  41. Department of Ophthalmology, University Hospital of North Norway, Tromsø, Norway

    Geir Bertelsen

  42. Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

    Geir Bertelsen

  43. Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands

    Carel Hoyng

  44. Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The Netherlands

    Arthur Bergen

  45. Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal

    Rufino Silva

  46. Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

    Rufino Silva

  47. Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal

    Rufino Silva

  48. Department of Ophthalmology, Inselspital, University Hospital, University of Bern, Bern, Switzerland

    Sebastian Wolf

  49. Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK

    Andrew Lotery

  50. Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK

    Astrid Fletcher

Authors
  1. Cécile Delcourt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jean-François Korobelnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gabriëlle H. S. Buitendijk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Paul J. Foster
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Christopher J. Hammond
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Stefano Piermarocchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Tunde Peto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Nomdo Jansonius
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Alireza Mirshahi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ruth E. Hogg
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Lionel Bretillon
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Fotis Topouzis
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Gabor Deak
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Jakob Grauslund
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Rebecca Broe
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Eric H. Souied
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Catherine Creuzot-Garcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. José Sahel
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Vincent Daien
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Terho Lehtimäki
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Hans-Werner Hense
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Elena Prokofyeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Konrad Oexle
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Jugnoo S. Rahi
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. Phillippa M. Cumberland
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. Steffen Schmitz-Valckenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. Sascha Fauser
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. Geir Bertelsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. Carel Hoyng
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. Arthur Bergen
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. Rufino Silva
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. Sebastian Wolf
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. Andrew Lotery
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. Usha Chakravarthy
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. Astrid Fletcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. Caroline C. W. Klaver
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cécile Delcourt.

Ethics declarations

Conflict of interest

C Delcourt received research grants from Laboratoires Théa and is board member for Bausch + Lomb, Laboratoires Théa and Novartis; JF Korobelnik is consultant for Alcon, Allergan, Bayer, Horus, Novartis, Roche, Théa, Zeiss; P Foster received honoraria from Carl Zeiss Meditech and Allergan (UK) and travel grants and unrestricted research grants from Alcon; A Mirshahi received research grants from Novartis and Bayer; L Bretillon received research grants from Laboratoires Horus Pharma, Laboratoires, THEA, Laboratoires Fournier/Abbott, travel grants from Laboratoires Horus Pharma, honoraria from Laboratoires Chauvin Bausch & Lomb, and is consultant for Novartis; F Topouzis received support from a project sponsor from Pfizer, Novartis, Alcon and Laboratoires Thea, honoraria for speaking at symposia from Alcon and is board member for Alcon, Bausch + Lomb, Humphrey, Zeiss, Allergan, Pfizer, Laboratoires Théa and Novartis; EH Souied is board member for Novartis, Bayer, Thea, Allergan; J Sahel is founder of Pixium Vision and Gensight Biologics and is consultant for Pixium Vision, Gensight Biologics, Sanofi Fovea, Genesignal and Vision Medecine; R Silva is member of Advisory board for Allergan, Bayer, Alimera, Novartis, THEA, Alcon. Other authors have no potential conflict of interest.

Additional information

On behalf of the European Eye Epidemiology (E3) consortium.

Please see “Appendix” section for European Eye Epidemiology (E3) consortium members.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 118 kb)

Appendix: European Eye Epidemiology (E3) consortium members

Appendix: European Eye Epidemiology (E3) consortium members

First name

Last name

Institution

City

Country

Niyazi

Acar

Inra-University of Burgundy

Dijon

France

Eleftherios

Anastosopoulos

University of Thessaloniki

Thessaloniki

Greece

Augusto

Azuara-Blanco

Queen’s University

Belfast

UK

Arthur

Bergen

Netherlands Institute for Neurosciences-KNAW

Amsterdam

Netherlands

Geir

Bertelsen

University of Tromso

Tromso

Norway

Christine

Binquet

University Hospital of Dijon

Dijon

France

Alan

Bird

Moorfield’s Eye Hospital

London

UK

Lionel

Brétillon

Inra-University of Burgundy

Dijon

France

Alain

Bron

University Hospital of Dijon

Dijon

France

Gabrielle

Buitendijk

Erasmus Medical Center

Rotterdam

Netherlands

Maria Luz

Cachulo

AIBILI/CHUC

Coimbra

Portugal

Usha

Chakravarthy

Queen’s University

Belfast

UK

Michelle

Chan

UCL Institute of Ophthalmology

London

UK

Petrus

Chang

University of Bonn

Bonn

Germany

Annemarie

Colijn

Erasmus Medical Center

Rotterdam

Netherlands

Audrey

Cougnard-Grégoire

University of Bordeaux Segalen

Bordeaux

France

Catherine

Creuzot-Garcher

University Hospital of Dijon

Dijon

France

Phillippa

Cumberland

UCL Institute of Child Health

London

UK

José

Cunha-Vaz

AIBILI/CHUC

Coimbra

Portugal

Vincent

Daien

Inserm U1061

Montpellier

France

Gabor

Deak

Medical University of Vienna

Vienna

Austria

Cécile

Delcourt

University of Bordeaux Segalen

Bordeaux

France

Marie-Noëlle

Delyfer

University of Bordeaux Segalen

Bordeaux

France

Anneke

den Hollander

Radboud University

Nijmegen

Netherlands

Martha

Dietzel

University of Muenster

Muenster

Germany

Maja Gran

Erke

University of Tromso

Tromso

Norway

Sascha

Fauser

University Eye Hospital

Cologne

Germany

Robert

Finger

University of Bonn

Bonn

Germany

Astrid

Fletcher

London School of Hygiene and Tropical Medicine

London

UK

Paul

Foster

UCL Institute of Ophthalmology

London

UK

Panayiota

Founti

University of Thessaloniki

Thessaloniki

Greece

Arno

Göbel

University of Bonn

Bonn

Germany

Theo

Gorgels

Netherlands Institute for Neurosciences-KNAW

Amsterdam

Netherlands

Jakob

Grauslund

University of Southern Denmark

Odense

Denmark

Franz

Grus

University Medical Center Mainz

Mainz

Germany

Christopher

Hammond

King’s College

London

UK

Catherine

Helmer

University of Bordeaux Segalen

Bordeaux

France

Hans-Werner

Hense

University of Muenster

Muenster

Germany

Manuel

Hermann

University Eye Hospital

Cologne

Germany

René

Hoehn

University Medical Center

Mainz

Germany

Ruth

Hogg

Queen’s University

Belfast

UK

Frank

Holz

University of Bonn

Bonn

Germany

Carel

Hoyng

Radboud University

Nijmegen

Netherlands

Nomdo

Jansonius

Erasmus Medical Center

Rotterdam

Netherlands

Sarah

Janssen

Netherlands Institute for Neurosciences-KNAW

Amsterdam

Netherlands

Anthony

Khawaja

UCL Institute of Ophthalmology

London

UK

Caroline

Klaver

Erasmus Medical Center

Rotterdam

Netherlands

Jean-François

Korobelnik

University of Bordeaux Segalen

Bordeaux

France

Julia

Lamparter

University Medical Center Mainz

Mainz

Germany

Mélanie

Le Goff

University of Bordeaux Segalen

Bordeaux

France

Sergio

Leal

AIBILI/CHUC

Coimbra

Portugal

Yara

Lechanteur

Radboud University

Nijmegen

Netherlands

Terho

Lehtimäki

Pirkanmaa Hospital District

Tampere

Finland

Andrew

Lotery

University of Southampton

Southampton

UK

Irene

Leung

Moorfield’s Eye Hospital

London

UK

Matthias

Mauschitz

University of Bonn

Bonn

Germany

Bénédicte

Merle

University of Bordeaux Segalen

Bordeaux

France

Verena

Meyer zu Westrup

University of Muenster

Muenster

Germany

Edoardo

Midena

University of Padova

Padova

Italy

Stefania

Miotto

University of Padova

Padova

Italy

Alireza

Mirshahi

University Medical Center

Mainz

Germany

Sadek

Mohan-Saïd

Institut de la Vision

Paris

France

Alyson

Muldrew

Queen’s University

Belfast

UK

Michael

Mueller

Pirkanmaa Hospital District

Tampere

Finland

Sandrina

Nunes

AIBILI/CHUC

Coimbra

Portugal

Konrad

Oexle

Institue of Human Genetics

Munich

Germany

Tunde

Peto

Moorfield’s Eye Hospital

London

UK

Stefano

Piermarocchi

University of Padova

Padova

Italy

Elena

Prokofyeva

Inserm U1018

Paris

France

Jugnoo

Rahi

UCL Institute of Ophthalmology

London

UK

Olli

Raitakari

Pirkanmaa Hospital District

Tampere

Finland

Luisa

Ribeiro

AIBILI/CHUC

Coimbra

Portugal

Marie-Bénédicte

Rougier

University of Bordeaux Segalen

Bordeaux

France

José

Sahel

Institut de la Vision

Paris

France

Aggeliki

Salonikiou

University of Thessaloniki

Thessaloniki

Greece

Clarisa

Sanchez

Radboud University

Nijmegen

Netherlands

Steffen

Schmitz-Valckenberg

University of Bonn

Bonn

Germany

Cédric

Schweitzer

University of Bordeaux Segalen

Bordeaux

France

Tatiana

Segato

University of Padova

Padova

Italy

Jasmin

Shehata

Medical University of Vienna

Vienna

Austria

Rufino

Silva

AIBILI/CHUC

Coimbra

Portugal

Giuliana

Silvestri

Queen’s University

Belfast

UK

Christian

Simader

Medical University of Vienna

Vienna

Austria

Eric

Souied

University Hospital of Créteil

Créteil

France

Henriet

Springelkamp

Erasmus Medical Center

Rotterdam

Netherlands

Robyn

Tapp

Pirkanmaa Hospital District

Tampere

Finland

Fotis

Topouzis

University of Thessaloniki

Thessaloniki

Greece

Virginie

Verhoeven

Erasmus Medical Center

Rotterdam

Netherlands

Therese

Von Hanno

University of Tromso

Tromso

Norway

Stela

Vujosevic

University of Padova

Padova

Italy

Katie

Williams

King’s College London

London

UK

Christian

Wolfram

University Medical Center

Mainz

Germany

Jennifer

Yip

UCL Institute of Ophthalmology

London

UK

Jennyfer

Zerbib

University Hospital of Créteil

Créteil

France

Isabella

Zwiener

University Medical Center

Mainz

Germany

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Delcourt, C., Korobelnik, JF., Buitendijk, G.H.S. et al. Ophthalmic epidemiology in Europe: the “European Eye Epidemiology” (E3) consortium. Eur J Epidemiol 31, 197–210 (2016). https://doi.org/10.1007/s10654-015-0098-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10654-015-0098-2

Keywords

Search

Navigation