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Ophthalmic epidemiology in Europe: the “European Eye Epidemiology” (E3) consortium

Abstract

The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case–control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The aim of the consortium is to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe, with particular focus on the harmonization of methods for future research, estimation and projection of frequency and impact of visual outcomes in European populations (including temporal trends and European subregions), identification of risk factors and pathways for eye diseases (lifestyle, vascular and metabolic factors, genetics, epigenetics and biomarkers) and development and validation of prediction models for eye diseases. Coordinating these existing data will allow a detailed study of the risk factors and consequences of eye diseases and visual impairment, including study of international geographical variation which is not possible in individual studies. It is expected that collaborative work on these existing data will provide additional knowledge, despite the fact that the risk factors and the methods for collecting them differ somewhat among the participating studies. Most studies also include biobanks of various biological samples, which will enable identification of biomarkers to detect and predict occurrence and progression of eye diseases. This article outlines the rationale of the consortium, its design and presents a summary of the methodology.

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Acknowledgments

The E3 consortium thanks Cécile Delcourt, Jean-François Korobelnik, Marie-Bénédicte Rougier and Marie-Noëlle Delyfer for organizing the meetings in Bordeaux in 2011, 2012 and 2013, Stefano Piermarocchi for organizing the meeting in Rome in 2014 and Chris Hammond, Paul Foster and Tunde Peto for organizing the meeting in London in 2015. These workshops have received financial support from Carl Zeiss Meditec AG, Laboratoires Théa, Novartis and OOgroup.

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Correspondence to Cécile Delcourt.

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Conflict of interest

C Delcourt received research grants from Laboratoires Théa and is board member for Bausch + Lomb, Laboratoires Théa and Novartis; JF Korobelnik is consultant for Alcon, Allergan, Bayer, Horus, Novartis, Roche, Théa, Zeiss; P Foster received honoraria from Carl Zeiss Meditech and Allergan (UK) and travel grants and unrestricted research grants from Alcon; A Mirshahi received research grants from Novartis and Bayer; L Bretillon received research grants from Laboratoires Horus Pharma, Laboratoires, THEA, Laboratoires Fournier/Abbott, travel grants from Laboratoires Horus Pharma, honoraria from Laboratoires Chauvin Bausch & Lomb, and is consultant for Novartis; F Topouzis received support from a project sponsor from Pfizer, Novartis, Alcon and Laboratoires Thea, honoraria for speaking at symposia from Alcon and is board member for Alcon, Bausch + Lomb, Humphrey, Zeiss, Allergan, Pfizer, Laboratoires Théa and Novartis; EH Souied is board member for Novartis, Bayer, Thea, Allergan; J Sahel is founder of Pixium Vision and Gensight Biologics and is consultant for Pixium Vision, Gensight Biologics, Sanofi Fovea, Genesignal and Vision Medecine; R Silva is member of Advisory board for Allergan, Bayer, Alimera, Novartis, THEA, Alcon. Other authors have no potential conflict of interest.

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On behalf of the European Eye Epidemiology (E3) consortium.

Please see “Appendix” section for European Eye Epidemiology (E3) consortium members.

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Appendix: European Eye Epidemiology (E3) consortium members

Appendix: European Eye Epidemiology (E3) consortium members

First name Last name Institution City Country
Niyazi Acar Inra-University of Burgundy Dijon France
Eleftherios Anastosopoulos University of Thessaloniki Thessaloniki Greece
Augusto Azuara-Blanco Queen’s University Belfast UK
Arthur Bergen Netherlands Institute for Neurosciences-KNAW Amsterdam Netherlands
Geir Bertelsen University of Tromso Tromso Norway
Christine Binquet University Hospital of Dijon Dijon France
Alan Bird Moorfield’s Eye Hospital London UK
Lionel Brétillon Inra-University of Burgundy Dijon France
Alain Bron University Hospital of Dijon Dijon France
Gabrielle Buitendijk Erasmus Medical Center Rotterdam Netherlands
Maria Luz Cachulo AIBILI/CHUC Coimbra Portugal
Usha Chakravarthy Queen’s University Belfast UK
Michelle Chan UCL Institute of Ophthalmology London UK
Petrus Chang University of Bonn Bonn Germany
Annemarie Colijn Erasmus Medical Center Rotterdam Netherlands
Audrey Cougnard-Grégoire University of Bordeaux Segalen Bordeaux France
Catherine Creuzot-Garcher University Hospital of Dijon Dijon France
Phillippa Cumberland UCL Institute of Child Health London UK
José Cunha-Vaz AIBILI/CHUC Coimbra Portugal
Vincent Daien Inserm U1061 Montpellier France
Gabor Deak Medical University of Vienna Vienna Austria
Cécile Delcourt University of Bordeaux Segalen Bordeaux France
Marie-Noëlle Delyfer University of Bordeaux Segalen Bordeaux France
Anneke den Hollander Radboud University Nijmegen Netherlands
Martha Dietzel University of Muenster Muenster Germany
Maja Gran Erke University of Tromso Tromso Norway
Sascha Fauser University Eye Hospital Cologne Germany
Robert Finger University of Bonn Bonn Germany
Astrid Fletcher London School of Hygiene and Tropical Medicine London UK
Paul Foster UCL Institute of Ophthalmology London UK
Panayiota Founti University of Thessaloniki Thessaloniki Greece
Arno Göbel University of Bonn Bonn Germany
Theo Gorgels Netherlands Institute for Neurosciences-KNAW Amsterdam Netherlands
Jakob Grauslund University of Southern Denmark Odense Denmark
Franz Grus University Medical Center Mainz Mainz Germany
Christopher Hammond King’s College London UK
Catherine Helmer University of Bordeaux Segalen Bordeaux France
Hans-Werner Hense University of Muenster Muenster Germany
Manuel Hermann University Eye Hospital Cologne Germany
René Hoehn University Medical Center Mainz Germany
Ruth Hogg Queen’s University Belfast UK
Frank Holz University of Bonn Bonn Germany
Carel Hoyng Radboud University Nijmegen Netherlands
Nomdo Jansonius Erasmus Medical Center Rotterdam Netherlands
Sarah Janssen Netherlands Institute for Neurosciences-KNAW Amsterdam Netherlands
Anthony Khawaja UCL Institute of Ophthalmology London UK
Caroline Klaver Erasmus Medical Center Rotterdam Netherlands
Jean-François Korobelnik University of Bordeaux Segalen Bordeaux France
Julia Lamparter University Medical Center Mainz Mainz Germany
Mélanie Le Goff University of Bordeaux Segalen Bordeaux France
Sergio Leal AIBILI/CHUC Coimbra Portugal
Yara Lechanteur Radboud University Nijmegen Netherlands
Terho Lehtimäki Pirkanmaa Hospital District Tampere Finland
Andrew Lotery University of Southampton Southampton UK
Irene Leung Moorfield’s Eye Hospital London UK
Matthias Mauschitz University of Bonn Bonn Germany
Bénédicte Merle University of Bordeaux Segalen Bordeaux France
Verena Meyer zu Westrup University of Muenster Muenster Germany
Edoardo Midena University of Padova Padova Italy
Stefania Miotto University of Padova Padova Italy
Alireza Mirshahi University Medical Center Mainz Germany
Sadek Mohan-Saïd Institut de la Vision Paris France
Alyson Muldrew Queen’s University Belfast UK
Michael Mueller Pirkanmaa Hospital District Tampere Finland
Sandrina Nunes AIBILI/CHUC Coimbra Portugal
Konrad Oexle Institue of Human Genetics Munich Germany
Tunde Peto Moorfield’s Eye Hospital London UK
Stefano Piermarocchi University of Padova Padova Italy
Elena Prokofyeva Inserm U1018 Paris France
Jugnoo Rahi UCL Institute of Ophthalmology London UK
Olli Raitakari Pirkanmaa Hospital District Tampere Finland
Luisa Ribeiro AIBILI/CHUC Coimbra Portugal
Marie-Bénédicte Rougier University of Bordeaux Segalen Bordeaux France
José Sahel Institut de la Vision Paris France
Aggeliki Salonikiou University of Thessaloniki Thessaloniki Greece
Clarisa Sanchez Radboud University Nijmegen Netherlands
Steffen Schmitz-Valckenberg University of Bonn Bonn Germany
Cédric Schweitzer University of Bordeaux Segalen Bordeaux France
Tatiana Segato University of Padova Padova Italy
Jasmin Shehata Medical University of Vienna Vienna Austria
Rufino Silva AIBILI/CHUC Coimbra Portugal
Giuliana Silvestri Queen’s University Belfast UK
Christian Simader Medical University of Vienna Vienna Austria
Eric Souied University Hospital of Créteil Créteil France
Henriet Springelkamp Erasmus Medical Center Rotterdam Netherlands
Robyn Tapp Pirkanmaa Hospital District Tampere Finland
Fotis Topouzis University of Thessaloniki Thessaloniki Greece
Virginie Verhoeven Erasmus Medical Center Rotterdam Netherlands
Therese Von Hanno University of Tromso Tromso Norway
Stela Vujosevic University of Padova Padova Italy
Katie Williams King’s College London London UK
Christian Wolfram University Medical Center Mainz Germany
Jennifer Yip UCL Institute of Ophthalmology London UK
Jennyfer Zerbib University Hospital of Créteil Créteil France
Isabella Zwiener University Medical Center Mainz Germany

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Delcourt, C., Korobelnik, JF., Buitendijk, G.H.S. et al. Ophthalmic epidemiology in Europe: the “European Eye Epidemiology” (E3) consortium. Eur J Epidemiol 31, 197–210 (2016). https://doi.org/10.1007/s10654-015-0098-2

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Keywords

  • Epidemiology
  • Ophthalmology
  • Eye diseases
  • Prevalence
  • Risk factors
  • Europe