European Journal of Epidemiology

, Volume 31, Issue 2, pp 197–210 | Cite as

Ophthalmic epidemiology in Europe: the “European Eye Epidemiology” (E3) consortium

  • Cécile Delcourt
  • Jean-François Korobelnik
  • Gabriëlle H. S. Buitendijk
  • Paul J. Foster
  • Christopher J. Hammond
  • Stefano Piermarocchi
  • Tunde Peto
  • Nomdo Jansonius
  • Alireza Mirshahi
  • Ruth E. Hogg
  • Lionel Bretillon
  • Fotis Topouzis
  • Gabor Deak
  • Jakob Grauslund
  • Rebecca Broe
  • Eric H. Souied
  • Catherine Creuzot-Garcher
  • José Sahel
  • Vincent Daien
  • Terho Lehtimäki
  • Hans-Werner Hense
  • Elena Prokofyeva
  • Konrad Oexle
  • Jugnoo S. Rahi
  • Phillippa M. Cumberland
  • Steffen Schmitz-Valckenberg
  • Sascha Fauser
  • Geir Bertelsen
  • Carel Hoyng
  • Arthur Bergen
  • Rufino Silva
  • Sebastian Wolf
  • Andrew Lotery
  • Usha Chakravarthy
  • Astrid Fletcher
  • Caroline C. W. Klaver
NEW STUDY

Abstract

The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case–control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The aim of the consortium is to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe, with particular focus on the harmonization of methods for future research, estimation and projection of frequency and impact of visual outcomes in European populations (including temporal trends and European subregions), identification of risk factors and pathways for eye diseases (lifestyle, vascular and metabolic factors, genetics, epigenetics and biomarkers) and development and validation of prediction models for eye diseases. Coordinating these existing data will allow a detailed study of the risk factors and consequences of eye diseases and visual impairment, including study of international geographical variation which is not possible in individual studies. It is expected that collaborative work on these existing data will provide additional knowledge, despite the fact that the risk factors and the methods for collecting them differ somewhat among the participating studies. Most studies also include biobanks of various biological samples, which will enable identification of biomarkers to detect and predict occurrence and progression of eye diseases. This article outlines the rationale of the consortium, its design and presents a summary of the methodology.

Keywords

Epidemiology Ophthalmology Eye diseases Prevalence Risk factors Europe 

Notes

Acknowledgments

The E3 consortium thanks Cécile Delcourt, Jean-François Korobelnik, Marie-Bénédicte Rougier and Marie-Noëlle Delyfer for organizing the meetings in Bordeaux in 2011, 2012 and 2013, Stefano Piermarocchi for organizing the meeting in Rome in 2014 and Chris Hammond, Paul Foster and Tunde Peto for organizing the meeting in London in 2015. These workshops have received financial support from Carl Zeiss Meditec AG, Laboratoires Théa, Novartis and OOgroup.

Compliance with ethical standards

Conflict of interest

C Delcourt received research grants from Laboratoires Théa and is board member for Bausch + Lomb, Laboratoires Théa and Novartis; JF Korobelnik is consultant for Alcon, Allergan, Bayer, Horus, Novartis, Roche, Théa, Zeiss; P Foster received honoraria from Carl Zeiss Meditech and Allergan (UK) and travel grants and unrestricted research grants from Alcon; A Mirshahi received research grants from Novartis and Bayer; L Bretillon received research grants from Laboratoires Horus Pharma, Laboratoires, THEA, Laboratoires Fournier/Abbott, travel grants from Laboratoires Horus Pharma, honoraria from Laboratoires Chauvin Bausch & Lomb, and is consultant for Novartis; F Topouzis received support from a project sponsor from Pfizer, Novartis, Alcon and Laboratoires Thea, honoraria for speaking at symposia from Alcon and is board member for Alcon, Bausch + Lomb, Humphrey, Zeiss, Allergan, Pfizer, Laboratoires Théa and Novartis; EH Souied is board member for Novartis, Bayer, Thea, Allergan; J Sahel is founder of Pixium Vision and Gensight Biologics and is consultant for Pixium Vision, Gensight Biologics, Sanofi Fovea, Genesignal and Vision Medecine; R Silva is member of Advisory board for Allergan, Bayer, Alimera, Novartis, THEA, Alcon. Other authors have no potential conflict of interest.

Supplementary material

10654_2015_98_MOESM1_ESM.docx (119 kb)
Supplementary material 1 (DOCX 118 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Cécile Delcourt
    • 1
    • 2
  • Jean-François Korobelnik
    • 1
    • 2
    • 3
  • Gabriëlle H. S. Buitendijk
    • 4
    • 9
  • Paul J. Foster
    • 5
  • Christopher J. Hammond
    • 6
  • Stefano Piermarocchi
    • 7
  • Tunde Peto
    • 5
  • Nomdo Jansonius
    • 8
    • 9
  • Alireza Mirshahi
    • 10
  • Ruth E. Hogg
    • 11
  • Lionel Bretillon
    • 12
    • 13
    • 14
  • Fotis Topouzis
    • 15
  • Gabor Deak
    • 16
  • Jakob Grauslund
    • 17
    • 18
  • Rebecca Broe
    • 17
    • 18
  • Eric H. Souied
    • 19
  • Catherine Creuzot-Garcher
    • 12
    • 13
    • 14
    • 20
  • José Sahel
    • 21
    • 22
    • 23
    • 24
    • 25
    • 26
  • Vincent Daien
    • 27
    • 28
    • 29
  • Terho Lehtimäki
    • 30
    • 31
  • Hans-Werner Hense
    • 32
  • Elena Prokofyeva
    • 33
    • 34
    • 35
  • Konrad Oexle
    • 36
  • Jugnoo S. Rahi
    • 5
    • 37
    • 38
  • Phillippa M. Cumberland
    • 37
    • 38
  • Steffen Schmitz-Valckenberg
    • 39
  • Sascha Fauser
    • 40
  • Geir Bertelsen
    • 41
    • 42
  • Carel Hoyng
    • 43
  • Arthur Bergen
    • 44
  • Rufino Silva
    • 45
    • 46
    • 47
  • Sebastian Wolf
    • 48
  • Andrew Lotery
    • 49
  • Usha Chakravarthy
    • 11
  • Astrid Fletcher
    • 50
  • Caroline C. W. Klaver
    • 4
    • 9
  1. 1.Univ. BordeauxISPEDBordeaux CedexFrance
  2. 2.INSERMCentre INSERM U897-Epidemiologie-BiostatistiqueBordeauxFrance
  3. 3.Service d’OphtalmologieCHU de BordeauxBordeauxFrance
  4. 4.Department of OphthalmologyErasmus Medical CenterRotterdamThe Netherlands
  5. 5.NIHR Biomedical Research CentreMoorfields Eye Hospital, NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK
  6. 6.Department of Ophthalmology, Department of Twin Research and Genetic EpidemiologyKing’s College London, St Thomas’ HospitalLondonUK
  7. 7.Department of OphthalmologyUniversity of PaduaPaduaItaly
  8. 8.Department of OphthalmologyUniversity of Groningen, University Medical Center GroningenGroningenThe Netherlands
  9. 9.Department of EpidemiologyErasmus Medical Center RotterdamRotterdamThe Netherlands
  10. 10.Department OphthalmologyUniversity Medical CenterMainzGermany
  11. 11.Centre for Experimental MedicineQueen’s University of BelfastBelfastUK
  12. 12.INRAUMR1324 Centre des Sciences du Goût et de l’AlimentationDijonFrance
  13. 13.CNRSUMR6265 Centre des Sciences du Goût et de l’AlimentationDijonFrance
  14. 14.Université de BourgogneCentre des Sciences du Goût et de l’AlimentationDijonFrance
  15. 15.Laboratory of Research and Clinical Applications in Ophthalmology, Department of OphthalmologyAristotle University of Thessaloniki, AHEPA HospitalThessalonikiGreece
  16. 16.Vienna Reading Center, Department of OphthalmologyMedical University of ViennaViennaAustria
  17. 17.Research Unit of Ophthalmology, Institute of Clinical Research, University of Southern DenmarkOdenseDenmark
  18. 18.Department of OphthalmologyOdense University HospitalOdenseDenmark
  19. 19.Service d’ophtalmologie, Centre Hospitalier Intercommunal de Creteil, CRC, CRBUniversite Paris EstCreteilFrance
  20. 20.Department of OphthalmologyCHUDijonFrance
  21. 21.Institut de la VisionUPMC Univ Paris 06ParisFrance
  22. 22.INSERMParisFrance
  23. 23.CNRSParisFrance
  24. 24.Centre Hospitalier National d’Ophtalmologie des Quinze-VingtsParisFrance
  25. 25.Fondation Ophtalmologique RothschildParisFrance
  26. 26.Institute of OphthalmologyUniversity College LondonLondonUK
  27. 27.INSERMMontpellierFrance
  28. 28.Univ Montpellier 1MontpellierFrance
  29. 29.Department of OphthalmologyGui De Chauliac HospitalMontpellierFrance
  30. 30.Department of Clinical ChemistryFimlab LaboratoriesTampereFinland
  31. 31.University of Tampere School of MedicineTampereFinland
  32. 32.Clinical Epidemiology, Institute of Epidemiology and Social MedicineUniversity MünsterMünsterGermany
  33. 33.INSERM, U1018, Centre for Research in Epidemiology and Population Health (CESP)Epidemiology of Occupational and Social Determinants of HealthVillejuifFrance
  34. 34.Université de Versailles Saint-QuentinVillejuifFrance
  35. 35.Northern State Medical UniversityArkhangelskRussia
  36. 36.Institute of Human GeneticsTechnische Universität MünchenMunichGermany
  37. 37.Population, Policy and Practice ProgrammeUCL Institute of Child HealthLondonUK
  38. 38.Ulverscroft Vision Research GroupUCL Institute of Child HealthLondonUK
  39. 39.Department of Ophthalmology, GRADE Reading CenterUniversity of BonnBonnGermany
  40. 40.Center of OphthalmologyUniversity Hospital CologneCologneGermany
  41. 41.Department of OphthalmologyUniversity Hospital of North NorwayTromsøNorway
  42. 42.Department of Community Medicine, Faculty of Health SciencesUniversity of TromsøTromsøNorway
  43. 43.Department of OphthalmologyRadboud University Medical CenterNijmegenThe Netherlands
  44. 44.Department of Clinical GeneticsAcademic Medical CentreAmsterdamThe Netherlands
  45. 45.Department of OphthalmologyCentro Hospitalar e Universitário de Coimbra (CHUC)CoimbraPortugal
  46. 46.Faculty of Medicine (FMUC)University of CoimbraCoimbraPortugal
  47. 47.Association for Innovation and Biomedical Research on Light and Image (AIBILI)CoimbraPortugal
  48. 48.Department of Ophthalmology, Inselspital, University HospitalUniversity of BernBernSwitzerland
  49. 49.Clinical and Experimental Sciences, Faculty of MedicineUniversity of SouthamptonSouthamptonUK
  50. 50.Faculty of Epidemiology and Population HealthLondon School of Hygiene & Tropical MedicineLondonUK

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