European Journal of Epidemiology

, Volume 29, Issue 2, pp 79–88 | Cite as

Dietary fiber intake and risk of type 2 diabetes: a dose–response analysis of prospective studies

  • Baodong Yao
  • Hong Fang
  • Wanghong Xu
  • Yujie Yan
  • Huilin Xu
  • Yinan Liu
  • Miao Mo
  • Hua Zhang
  • Yanping ZhaoEmail author


Observational studies suggest an association between dietary fiber intake and risk of type 2 diabetes, but the results are inconclusive. We conducted a meta-analysis of prospective studies evaluating the associations of dietary fiber intake and risk of type 2 diabetes. Relevant studies were identified by searching EMBASE (from 1974 to April 2013) and PubMed (from 1966 to April 2013). The fixed or random-effect model was selected based on the homogeneity test among studies. In addition, a 2-stage random-effects dose–response meta-analysis was performed. We identified 17 prospective cohort studies of dietary fiber intake and risk of type 2 diabetes involving 19,033 cases and 488,293 participants. The combined RR (95 % CI) of type 2 diabetes for intake of total dietary fiber, cereal fiber, fruit fiber and insoluble fiber was 0.81 (0.73–0.90), 0.77 (0.69–0.85), 0.94 (0.88–0.99) and 0.75 (0.63–0.89), respectively. A nonlinear relationship was found of total dietary fiber intake with risk of type 2 diabetes (P for nonlinearity < 0.01), and the RRs (95 % CI) of type 2 diabetes were 0.98 (0.90–1.06), 0.97 (0.87–1.07), 0.89 (0.80–0.99), 0.76 (0.65–0.88), and 0.66 (0.53–0.82) for 15, 20, 25, 30, and 35 g/day. The departure from nonlinear relationship was not significant (P for nonlinearity = 0.72), and the risk of type 2 diabetes decreased by 6 % (RR 0.94, 95 % CI 0.93–0.96) for 2 g/day increment in cereal fiber intake. Findings from this meta-analysis indicate that the intakes of dietary fiber may be inversely associated with risk of type 2 diabetes.


Dietary fiber Type 2 diabetes Prospective studies Meta-analysis 




Conflict of interest

No conflict of interest existed for any of the authors.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Baodong Yao
    • 1
  • Hong Fang
    • 1
  • Wanghong Xu
    • 2
  • Yujie Yan
    • 1
  • Huilin Xu
    • 1
  • Yinan Liu
    • 1
  • Miao Mo
    • 2
  • Hua Zhang
    • 2
  • Yanping Zhao
    • 1
    Email author
  1. 1.Shanghai Minhang Center for Disease Control and PreventionShanghaiChina
  2. 2.The Key Laboratory of Public Health Safety of Ministry of Education, Department of Epidemiology, School of Public HealthFudan UniversityShanghaiChina

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