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Table 2 Association of BNP with selected characteristics in IFS2 and PRIME, adjusted for age

From: Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies

  IFS2 PRIME
N OR (95 % CI) N OR (95 % CI)
Age (years)
 <35 81 0.27 (0.10, 0.69)
 35–39 86 0.25 (0.10, 0.65)
 40–44 105 0.33 (0.15, 0.73)
 45–49 191 0.88 (0.54, 1.42)
 50–54 247 1.00 [ref] 1,006 1.00 [ref]
 55–60 276 2.12 (1.42, 3.16) 800 1.89 (1.50, 2.39)
P value trend    <0.001   
Smoking
 Never smoker 192 1.00 [ref] 614 1.00 [ref]
 Former smoker 179 1.19 (0.67, 2.14) 688 1.00 (0.76, 1.32)
 Current smoker 614 1.91 (1.20, 3.06) 504 0.95 (0.71, 1.29)
P value trend    0.002    0.796
Obesity class
 Underweight 19 0.38 (0.08, 1.76) 5
 Normal weight 395 1.00 [ref] 661 1.00 [ref]
 Over weight 386 0.77 (0.53, 1.10) 922 0.97 (0.75, 1.24)
 Obese 142 0.61 (0.36, 1.04) 180 1.07 (0.71, 1.61)
 Severely obese 38 0.65 (0.25, 1.67) 38 1.42 (0.67, 3.03)
P value trend    0.104    0.620
Hypertension
 Normotensive 407 1.00 [ref] 1,092 1.00 [ref]
 Mild hypertension 309 1.00 (0.66, 1.52) 456 1.04 (0.78, 1.38)
 Moderate hypertension 163 1.35 (0.85, 2.15) 178 1.76 (1.22, 2.52)
 Severe hypertension 103 2.45 (1.48, 4.05) 78 1.70 (1.01, 2.85)
P value trend    0.001    0.001
Angina (Rose questionnaire)
 No 893 1.00 [ref] 1,643 1.00 [ref]
 Yes 83 1.44 (0.95, 2.19) 163 2.77 (1.97, 3.90)
Stop for breath walking
 No 934 1.00 [ref] 1,188 1.00 [ref]
 Yes 44 2.37 (1.25, 4.52) 139 2.47 (1.66, 3.66)
  1. OR—odds ratio of being in the top 20 % of BNP distribution
  2. For IFS2 subjects are all men who had been interviewed themselves and had attended the medical examination. For both studies variation in total numbers reflect missing information
  3. Obesity class BMI ranges = Underweight (≤18.5); Normal weight (≥18.5–24.9); Over weight (≥25–29.9); Obese (≥30–34.9); Severely obese (≥35)
  4. Hypertension = Mild SBP 140–159 or DBP 90–99; Moderate 160–179 or 100–109; Severe 180+ or 110+
  5. Stop for breath walking based on response to question “Do you have to stop for breath when walking at your own pace on level ground?”