The authors thank Prof. Jaakko Tuomilehto, National Public Health Institute, Prof. Abdonas Tamosiunas, Institute of Cardiology, Prof. Hugh Tunstall-Pedoe, University of Dundee, Prof. Giancarlo Cesana, Università degli studi di Milano-Bicocca and Prof. Marco Ferrario, Università degli studi dell’Insubria for making their MONICA data available and commenting the manuscript. This work was supported by the GenomEUtwin Project grant from the European Commission under the programme ‘Quality of Life and Management of the Living Resources’ of 5th Framework Programme (No. QLG2-CT-2002-01254) and by the Academy of Finland via its grant number 53646.