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Intra-familial Transmission of Helicobacter pylori Infection in Children of Households with Multiple Generations in Vietnam

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Abstract

This community-based cross-sectional study in 533 participants from 135 households with multiple generations living in the same household aimed at investigating the relationship between Helicobacter pylori infection in children and the other household members. H. pylori infection in children was found significantly associated with the infection in mothers [OR (95% CI): 2.50 (1.19–5.26)], even after being adjusted for sex, age group and sibling number [adjusted OR (95% CI): 2.47 (1.12–5.47)]. It was also significantly associated with the infection in␣both parents [adjusted OR (95% CI): 4.14 (1.29–13.23)]. No significant association between H. pylori infection in the father, grandparent(s), uncle or aunt with that in their children was found. Results from the present study showed intra-familial transmission in a multi-generation population and supported the␣hypothesis of person-to-person transmission of H.␣pylori infection.

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References

  1. Marshall BJ, Warren JR. (1984) Unclassified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1: 1311–1314

    Article  PubMed  CAS  Google Scholar 

  2. El-Omar EM, Malfertheiner P. (2001) Helicobacter pylori infection and gastric cancer. Curr Opi Gastroenterol 17: S24–S27

    Article  Google Scholar 

  3. Chan KL, Leung WK. (2002) Peptic ulcer disease. Lancet 360: 933–941

    Article  PubMed  Google Scholar 

  4. Riccardi VM, Rotter JI. (1994) Familial Helicobacter pylori infecion. Societal factors, human genetics, and bacterial genrtics. Ann Int Med 120: 1043–1044

    PubMed  CAS  Google Scholar 

  5. Oderda G. (1999) Transmission of Helicobacter pylori infection. Can J Gastroenterol 13: 595–597

    PubMed  CAS  Google Scholar 

  6. Malaty HM, Nyren O. (2003) Epidemiology of Helicobacter pylori infection.. Helicobacter 8: 8–12

    Article  PubMed  Google Scholar 

  7. Mitchell JD, Mitchell HM, Tobias V. (1992) Acute Helicobacter pylori infection in an infant, associated with gastric ulceration and serological evidence of intra-familial transmission. Am J Gastroenterol 87: 382–386

    PubMed  CAS  Google Scholar 

  8. Drumm B, Perez-Perez GI, Blaser MJ, Sherman P. (1990) Intrafamilial clustering of Helicobacter pylori infecion. N Engl J Med 322: 359–363

    Article  PubMed  CAS  Google Scholar 

  9. Malaty HM, Graham DY, Klein PD, Evans DG, Adam E, Evans DJ. (1991) Transmission of Helicobacter pylori infection. Studies in families of healthy individuals. Scand J Gastroenterol 26: 927–932

    Article  PubMed  CAS  Google Scholar 

  10. Mitchell HM, Bohane T, Hawkes RA, Lee A. (1993) Helicobacter pylori infection within families. Zentralbl Bakteriol 280: 128–136

    PubMed  CAS  Google Scholar 

  11. Best LM, Veldhuyzen van Zanten SJO, Sherman PM, Benzanson GS. (1994) Serological detection of Helicobacter pylori antibodies in children and their parents. J Clin Microbiol 32: 1193–1196

    PubMed  CAS  Google Scholar 

  12. Bonamico M, Monti S, Luzzi I, et al. (1996) Helicobacter pylori infection in families of Helicobacter pylori-positive children. Ital J Gastroenterol 28:512–517

    PubMed  CAS  Google Scholar 

  13. Dominici P, Bellentani S, Rita Di Biase R, et al. (1999) Familial clustering of Helicobacter pylori infection: Population-base study. Br Med J 28; 319: 541

    Google Scholar 

  14. Elitsur Y, Adkins L, Saeed D, Neace C. (1999) Helicobacter pylori antibody profile in household members of children with H. pylori infection. J Clin Gastroenterol 29: 178–182

    Article  PubMed  CAS  Google Scholar 

  15. Malaty HM, Kumagai T, Tanaka E, et al. (2000) Evidence from 9-year birth cohort study in Japan of transmission ways in Helicobacter pylori infection. J Clin Microbiol 38: 1971–1973

    PubMed  CAS  Google Scholar 

  16. Ng BL, Ng HC, Goh KT, Ho B. (2001) Helicobacter pylori in familial clusters based on antibody profile. FEMS Immunol Med Microbiol 30: 139–142

    Article  PubMed  CAS  Google Scholar 

  17. Wizla-Derambure N, Michaud L, Ategbo S, et al. (2001) Familial and community environmental risk factors for Helicobacter pylori infection in children and adolescents. J Pediatr Gastroenterol Nutr 33: 58–63

    Article  PubMed  CAS  Google Scholar 

  18. Miyazaki M, Kato M, Takata T, Une H. (2002) Intrafamilial transmission of Helicobacter pylori: The association between a parent and an offspring with respect to the presence of anti-CagA antibody. J Infect Chemother 8:70–75

    PubMed  Google Scholar 

  19. Rothenbacher D, Bode G, Berg G, et al. (1999) Helicobacter pylori among preschool children and their parents: Evidence of parent-child transmission. J Infect Dis 179: 398–402

    Article  PubMed  CAS  Google Scholar 

  20. Rothenbacher D, Winkler M, Gonser T, Adler G, Brenner H. (2002) Role of infected parents in transmission of Helicobacter pylori to their children. Pediatr Infect Dis J 21: 674–679

    Article  PubMed  Google Scholar 

  21. Bodhidatta L, Hoge CW, Churnratananakul S, et al. (1993) Diagnosis of Helicobacter pylori infection in a developing country: Comparison of two ELISAs and a seroprevalence study. J Infect Dis 168: 1549–1553

    PubMed  CAS  Google Scholar 

  22. Graham DY, Adam E, Reddy GT, et al. (1991) Seroepidemiology of Helicobacter pylori in India: Comparison of developing and developed countries. Digest Dis Sci 36: 1084–1088

    Article  PubMed  CAS  Google Scholar 

  23. Sarker SA, Rahman MM, Mahalanabis D, et al. (1995) Prevalence of Helicobacter pylori infection in infants and family contacts in a poor Bangladesh community. Digest Dis Sci 40: 2669–72

    Article  PubMed  CAS  Google Scholar 

  24. McCallion WA, Murray LJ, Bailie AG, Dalzell AM, O’Reilley DPJ, Bamford KB. (1996) Helicobacter pylori infection in children: Relation with current household living conditions. Gut 39: 18–21

    Article  PubMed  CAS  Google Scholar 

  25. Goodman KJ, Correa P, Tegana Aux HJ, et al. (1996) Helicobacter pylori infection in the Colombian Andes: A population-based study of transmission pathways. Am J Epidemiol 144: 290–299

    PubMed  CAS  Google Scholar 

  26. Bamford KB, Bickley J, Collins JS, et al. (1993) Helicobacter pylori: Comparison of DNA fingerprints provides evidence for intrafamilial infection. Gut 34: 1348–1350

    Article  PubMed  CAS  Google Scholar 

  27. Wang JT, Sheu JC, Wang TH, Wu MS. (1993) Direct amplification and restriction pattern analysis of Helicobacter pylori in parents with duodenal ulcers and their families. J Infect Dis 168: 1544–1548

    PubMed  CAS  Google Scholar 

  28. Roma-Giannikou E, Karameris A, Balatsos B, et al. (2003) Intrafamilial spread of Heliocobacter pylori: A genetic analysis Helicobacter 8: 15–20

    Article  PubMed  CAS  Google Scholar 

  29. Kivi M, Tindberg Y, Sorberg M, et al. (2003) Concordance of Helicobacter pylori Strains within Families. J Clin Microbiol 41: 5604–5608

    Article  PubMed  Google Scholar 

  30. Ma JL, You WC, Gail MH, et al. (1998) Helicobacter pylori infection and mode of transmission in a population at high risk of stomach cancer. Int J Epidemiol 27: 570–573

    Article  PubMed  CAS  Google Scholar 

  31. Al Knawy BA, Ahmed ME, Mirdad S, El Mekki A, Al Ammari O. (2000) Intrafamilial clustering of Helicobacter pylori infection in Saudi Arabia. Can J Gastroenterol 14:772–774

    PubMed  CAS  Google Scholar 

  32. Goodman KJ, Correa P. (2000) Transmission of Helicobacter pylori among siblings. Lancet 355: 358–362

    Article  PubMed  CAS  Google Scholar 

  33. Yilmaz E, Dogan Y, Gurgoze MK, Unal S. (2002) Seroprevalence of Helicobacter pylori infection among children and their parents in eastern Turkey. J Paediatr Child Health 38: 183–186

    Article  PubMed  CAS  Google Scholar 

  34. Zhou H, Chan KL, Chu KM, Tam PK. (2000) Intrafamilial spread of Helicobacter pylori: A prospective study using urea breath test. J Pediatr Surg 35: 1672–1675

    Article  PubMed  CAS  Google Scholar 

  35. Glynn MK, Friedman CR, Gold BD, et al. (2002) Seroincidence of Helicobacter pylori infection in a cohort of rural Bolivian children: Acquisition and analysis of possible risk factors. Clin Infect Dis 35: 1059–1065

    Article  PubMed  Google Scholar 

  36. Rocha GA, Rocha AM, Silva LD, et al. (2003) Transmission of Helicobacter pylori infection in families of preschool-aged children from Minas Gerais, Brazil. Trop Med Int Health 8: 987–991

    Article  PubMed  Google Scholar 

  37. Sedlackova M, Soucek A, Dohnalova A. (1995) Helicobacter pylori infections: Familial clustering and transmission. Cas Lek Cesk 134: 651–654

    PubMed  CAS  Google Scholar 

  38. Hoang HT, Bengtsson C, Phung CD, Nyren O, Granstrom M. (2003) Seroprevalence of Helicobacter pylori infection in urban and rural Vietnam. Helicobacter 8: 481–482

    Google Scholar 

  39. Hoang TTH, Wheeldon TU, Bengtsson C, Phung DC, Sorberg M, Granstrom M. (2004) Enzyme-linked immunosorbent assay for Helicobacter pylori needs adjustment for the population investigated. J Clin Microbiol 42: 627–630

    Article  PubMed  CAS  Google Scholar 

  40. Hook-Nikanne J, Sistonen P, Kosunen TU. (1990) Effect of ABO blood group and secretory status on the frequency of Helicobacter pylori antibodies. Scand J Gastroenterol 25: 815–818

    Article  PubMed  CAS  Google Scholar 

  41. Malaty HM, Engstrand L, Pederson NL, Graham DY. (1994) Helicobacter pylori infection, genetic and environmental influences. A study of twins. Ann Intern Med 120: 982–986

    PubMed  CAS  Google Scholar 

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Acknowledgement

We would like thank Hanoi Medical University and the National Institute of Epidemiology and Hygiene for supporting the techniques and materials indispensable for this study; the personnel of the Digestive Division of the National Institute of Epidemiology and Hygiene, whose invaluable assistance makes these findings possible; Vietnam–USA REI for donation of iron and vitamins distributed to study participants; the authority and the staff of Bavi District Health Center and Tienphong Commune Health Center for their primordial involvement in the organization and participation of the field work; and the village inhabitants for their welcoming and participation.

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  1. Hanoi Medical University, Hanoi, Vietnam

    Van Bang Nguyen, Gia Khanh Nguyen, Dac Cam Phung, Karen Okrainec, Josette Raymond, Christophe Dupond, Odile Kremp, Nicolas Kalach & Gwenaelle Vidal-Trecan

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  1. Van Bang Nguyen
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  2. Gia Khanh Nguyen
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Correspondence to Van Bang Nguyen.

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Nguyen, V.B., Nguyen, G.K., Phung, D.C. et al. Intra-familial Transmission of Helicobacter pylori Infection in Children of Households with Multiple Generations in Vietnam. Eur J Epidemiol 21, 459–463 (2006). https://doi.org/10.1007/s10654-006-9016-y

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