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Phenotypic Subtypes in Attention Deficit Hyperactivity Disorder in an Isolated Population

  • Psychiatric Diseases
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Abstract

We address the use of two informants in genetic studies and whether familial aggregation is similar for the three phenotypic subtypes of ADHD. Lifetime ADHD was diagnosed in a Dutch isolated population using parents and teachers as informants, creating two subgroups (one or two informants), then further divided into three phenotypic categories (inattentive, hyperactive/impulsive, combined). Genealogy was collected for all patients. Mean kinship coefficients for the subgroups were calculated. Fifteen of 26 children were linked to a common ancestor within 10 generations. The mean kinship coefficient of patients confirmed by two informants was significantly higher than in patients only scored positive by one informant (p = 0.03). All patients of the inattentive subtype were connected to a common ancestor, which was significantly higher (p = 0.03) than expected. Eighty-one percent of these patients derive of consanguineous marriages, also higher than expected. This means that recessive mutations may be involved in the inattentive subtype. These patients were more closely related than those with the other phenotypes (p<0.01). Our data suggests that using two informants in diagnosing ADHD helps identify a phenotype with a strong genetic component. The inattentive phenotype showed strong familial clustering and evidence of a recessive origin.

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Authors and Affiliations

  1. Genetic Epidemiology Unit, Department of Epidemiology & Biostatistics, Erasmus Medical Centre, PO Box 1738, 3000, DR Rotterdam, The Netherlands

    Esther A. Croes, Sandra López León, Tessa A.M. Rademaker, Marieke C.J. Dekker, Ben A. Oostra & Cornelia M. Van Duijn

  2. Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, The Netherlands

    Rachid El Galta & Jeanine J. Houwing-Duistermaat

  3. Department of Child and Adolescent Psychiatry, Erasmus MC-Sophia, Rotterdam, The Netherlands

    Robert F. Ferdinand & Frank Verhulst

Authors
  1. Esther A. Croes
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  2. Rachid El Galta
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  3. Jeanine J. Houwing-Duistermaat
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  4. Robert F. Ferdinand
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  5. Sandra López León
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  6. Tessa A.M. Rademaker
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  7. Marieke C.J. Dekker
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  8. Ben A. Oostra
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  9. Frank Verhulst
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  10. Cornelia M. Van Duijn
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Correspondence to Cornelia M. Van Duijn.

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Croes, E., El Galta, R., Houwing-Duistermaat, J. et al. Phenotypic Subtypes in Attention Deficit Hyperactivity Disorder in an Isolated Population. Eur J Epidemiol 20, 789–794 (2005). https://doi.org/10.1007/s10654-005-0366-7

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  • DOI: https://doi.org/10.1007/s10654-005-0366-7

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