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Sreening of pregnant women for hepatitis B markers in a French Provincial University Hospital (Limoges) during 15 years

  • Hepatitis
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Abstract. During the 15 years from January 1984 to December 1998 the Limoges University Hospital screened 22,859 pregnant patients for hepatitis B surface antigen (HBs Ag) and identified 149 positives. The overall prevalence (0.65%) was intermediate between prevalences observed among women of French origin (0.29%), French West Indies islands (5.68%) and of foreign origin particulary South East Asian origin (7.14%) and Sub Saharan African origin (6.52%). Hepatitis B Virus (HBV) replication markers was detected with relative low frequence (HBe Ag: 14.4%; HBV-DNA: 13.7–20%) among HBs Ag positive mothers. Markers of delta hepatitis virus was found among 10.5% of the HBs Ag carrier pregnant women. During the 15 years study period variations of the global prevalence were not statistically significant. Universal prenatal screening and infant immunisation could greatly contribute to the control of HBV infection if the polemic about the hepatitis B vaccination recently propagated in France will not have a negative effect on the acceptance and national programme of vaccination.

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hepatitis B virus

HBs Ag :

hepatitis B surface antigen


ADN of hepatitis B virus

HBe Ag:

hepatitis B “e” antigen

anti HBe Ag :

hepatitis B “e” antibody


hepatitis B immune globulin


  • S Krugman (1985) ArticleTitleViral hepatitis: 1985 update. Pediatr Rev 7 3–11

    Google Scholar 

  • F Barin A Goudeau F Denis et al. (1982) ArticleTitleImmune response in neonates to hepatitis B vaccine. Lancet 1 251–253 Occurrence Handle10.1016/S0140-6736(82)90977-1 Occurrence Handle6120276 Occurrence Handle1:STN:280:DyaL387itl2hsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • RP Beasley LY Hwang CC Lin et al. (1981) ArticleTitleIncidence of hepatitis B virus infections in pre-school children in Taiwan. J Infect Dis 146 198–204

    Google Scholar 

  • RP Beasley LY Hwang CC Lin et al. (1981) ArticleTitleHepatitis B immune globulin (HBIG) efficacy in the interruption of perinatal transmission of hepatitis B virus carrier state. Lancet 2 388–393 Occurrence Handle6115159 Occurrence Handle1:STN:280:DyaL3M3mvFCmuw%3D%3D

    PubMed  CAS  Google Scholar 

  • RP Beasley LY Hwang CE Stevens et al. (1983) ArticleTitleEfficacy of hepatitis B immune globulin for prevention of perinatal transmission of the hepatitis B virus carrier state: Final report of a randomized double-blind, placebo-controlled trial. Hepatology 3 135–141 Occurrence Handle6339349 Occurrence Handle1:STN:280:DyaL3s7lvFWrsA%3D%3D Occurrence Handle10.1002/hep.1840030201

    Article  PubMed  CAS  Google Scholar 

  • RP Beasley LY Hwang (1983) ArticleTitlePostnatal infectivity of hepatitis B surface antigen-carrier mother. J Infect Dis 147 185–190 Occurrence Handle6827135 Occurrence Handle1:STN:280:DyaL3s7jslaktw%3D%3D

    PubMed  CAS  Google Scholar 

  • WK Chung JY Yoo HS Sun HY Lee IJ Lee SM Kim AM Prince (1985) ArticleTitlePrevention of perinatal transmission of hepatitis B virus: A comparison between the efficacy of passive and passive-active immunization in Korea. J Infect Dis 151 280–286 Occurrence Handle3155778 Occurrence Handle1:STN:280:DyaL2M7gs1CisQ%3D%3D

    PubMed  CAS  Google Scholar 

  • K Kanai A Takehiro H Noto et al. (1985) ArticleTitlePrevention of perinatal transmission of hepatitis B virus (HBV) to children of e antigen-positive HBV carier mothers by hepatitis B immune globulin and HBV vaccine. J Infect Dis 151 287–290 Occurrence Handle3155779 Occurrence Handle1:STN:280:DyaL2M7gs1Citg%3D%3D

    PubMed  CAS  Google Scholar 

  • P Maupas JP Chiron F Barin et al. (1981) ArticleTitleEfficacy of hepatitis B vaccine in prevention of early HBs Ag carrier state in children : Controled clinical trial in an endemic area (Senegal). Lancet 1 289–292 Occurrence Handle10.1016/S0140-6736(81)91908-5 Occurrence Handle6109938 Occurrence Handle1:STN:280:DyaL3M7itFCnsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • HW Reesink EE Reesink-Brongers BJT Lafeber-Schut et al. (1979) ArticleTitlePrevention of chronic HBs Ag carrier state in infants of HBs Ag positive mothers by hepatitis B immunoglobulin. Lancet 2 436–438 Occurrence Handle10.1016/S0140-6736(79)91491-0 Occurrence Handle89499 Occurrence Handle1:STN:280:DyaE1M3ktlGitQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SW Schalm JA Mazel GC Gast Particlede et al. (1989) ArticleTitlePrevention of hepatitis B infection in new-borns through mass screening and delayed vaccination of all infants of mothers with hepatitis B surface antigen. Pediatrics 83 1041–1048 Occurrence Handle2726331 Occurrence Handle1:STN:280:DyaL1M3mtlCksA%3D%3D

    PubMed  CAS  Google Scholar 

  • VCW Wong InstitutionalAuthorNameIp HMH HW Reesink (1987) ArticleTitlePrevention of the HBs Ag carrier state in new-born infants of mothers who are chronic carriers of HBs Ag and HBe Ag by administration of hepatitis B vaccine and hepatitis B immunoglobulin. Lancet 1 921–926

    Google Scholar 

  • P Armitage G Berry (1994) Statistical methods in medical research Blackwell Scientific Publications Oxford

    Google Scholar 

  • F Denis JL Tabaste S Ranger-Rogez InstitutionalAuthorNameThe Multicentric Group (1994) ArticleTitlePrevalence of HBs Ag in about 21,500 pregnant women: Survey at 12 French University Hospitals. Pathol Biol 42 533–538 Occurrence Handle7824328 Occurrence Handle1:STN:280:DyaK2M7isVOksQ%3D%3D

    PubMed  CAS  Google Scholar 

  • F Roudot-Thoraval F Kouadja V Wirquin et al. (1989) ArticleTitlePrevalence of HBs antigen and markers of B virus replication in a population of pregnant women in France. Gastroentérolog Clin Biol 13 353–356 Occurrence Handle1:STN:280:DyaL1M3ptVagsw%3D%3D

    CAS  Google Scholar 

  • P Marib E Havbold (1988) ArticleTitleHepatitis B marker incidence pregnancy. Deut Med Wochenschr 111 1757–1760

    Google Scholar 

  • R Cunnigham JL North Wood CD Kelly EH Box All NJ Andrews (1998) ArticleTitleRoutine antenatal screening for hepatitis B using pooled sera: Validation and review of 10 years experience J Clin Pathol 51 392–395

    Google Scholar 

  • D Woo M Cummins PA Davies DR Harvey R Hurley AP Waterson (1979) ArticleTitleVertical transmission of hepatitis B surface antigen in carrier mothers in two west London hospitals. Arch Dis Child 54 670–675 Occurrence Handle10.1136/adc.54.9.670 Occurrence Handle518104 Occurrence Handle1:STN:280:DyaL3c%2Fos1Gktw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • A Goudeau InstitutionalAuthorNameEuropean Regional study group (1990) ArticleTitleEpidemiology and eradication strategy for hepatitis B in Europe. Vaccine 8 5113–5116 Occurrence Handle10.1016/0264-410X(90)90230-J

    Article  Google Scholar 

  • M Maniez-Montreuil MV Dupressoir A M Courroucé (1996) ArticleTitleRéévaluation de la sensibilité des trousses de dépistage de l’antigène HBs (Ag HBs). Gazette Transfusion 121 15–25

    Google Scholar 

  • J Pillonel C Saura AM Courouce (1998) ArticleTitleScreening of viral markers for HIV, HBV, and HCV infections in blood donors in France and residual risk of viral transmission by blood transfusion. Euro surveillance 3 76–79 Occurrence Handle12631762

    PubMed  Google Scholar 

  • F Denis A Goudeau A Aufrere (1998) ArticleTitleSituation of the hepatitis B vaccination in France in 1996. Bull Soc Pathol Exotique 91 37–40 Occurrence Handle1:STN:280:DyaK1c3hvF2isg%3D%3D

    CAS  Google Scholar 

  • S Ranger M Mounier F Denis J Alain et al. (1990) ArticleTitlePrévalence des marqueurs des virus des hépatites B (Ag HBs, Ag HBc, ADN) et delta chez près de dix milles femmes enceintes à  Limoges (France). Pathol Biol (Paris) 38 694–699 Occurrence Handle1:STN:280:DyaK3M%2FksVGmtQ%3D%3D

    CAS  Google Scholar 

  • JC Soulié A Goudeau M Larsen F Parnet et al. (1991) ArticleTitlePrévention de la transmission périnatale du virus de l’hépatite B. Epidémiologie et rapport coût/efficacité da ns la région de Paris. Presse Med 20 939–44

    Google Scholar 

  • G Papaevangelou G Farmaki H Kada (1998) ArticleTitleHepatitis B maternal-fetal transmission in Southern Europe Intervirology 41 197–200 Occurrence Handle10.1159/000024936 Occurrence Handle10213896 Occurrence Handle1:STN:280:DyaK1M3jsVWmtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • RL Pierce S Smith B Rowe-West B Sterritt (1999) ArticleTitleHepatitis B maternal screening, infant vaccination and infant prophylaxis practices in North Carolina. Arch Pediatr Adolescent Med 153 619–623 Occurrence Handle1:STN:280:DyaK1M3osVWqtA%3D%3D

    CAS  Google Scholar 

  • PR Summers MK Biswas JG Pastorek ML Pernoll LG Smith BE Bean (1987) ArticleTitleThe pregnant hepatitis B carrier: Evidence favouring comprehensive antepartum screening. Obstet Gynecol 69 701–704 Occurrence Handle3574797 Occurrence Handle1:STN:280:DyaL2s3gt1Ogsw%3D%3D

    PubMed  CAS  Google Scholar 

  • HS Yusuf FJ Mahoney CN Shapiro E Maste L Polish (1996) ArticleTitleHospital-based evaluation of programs to prevent perinatal hepatitis B virus transmission. Arch Pediat Adol Med 150 593–597 Occurrence Handle1:STN:280:DyaK283ktVaksA%3D%3D

    CAS  Google Scholar 

  • GL Gilbert (1984) ArticleTitlePrevention of vertical transmission of hepatitis B. The place of routine screening in antenatal care, and the case for immunization of infants at risk Med J Aust 141 213–216 Occurrence Handle6482756 Occurrence Handle1:STN:280:DyaL2M%2Fht1WgtQ%3D%3D

    PubMed  CAS  Google Scholar 

  • PF Coleman YC Jack Chen IK Mushahwar (1999) ArticleTitleImmunoassay detection of hepatitis B surface antigen mutants. J Med Virol 59 19–24 Occurrence Handle10.1002/(SICI)1096-9071(199909)59:1<19::AID-JMV4>3.0.CO;2-B Occurrence Handle10440803 Occurrence Handle1:STN:280:DyaK1MznvFamuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • F Andre AJ Zuckerman (1994) ArticleTitleReview: Protective efficacy of hepatitis in neonates. J Med Virol 44 144–151 Occurrence Handle7852954 Occurrence Handle1:STN:280:DyaK2M7ls1Siug%3D%3D

    PubMed  CAS  Google Scholar 

  • A Goudeau P Coursaget F Barin F Dubois JP Chiron F Denis I Diop Mar (1982) Prevention of hepatitis B active and passive immunization Szmuness (Eds) et al. “Viral Hepatitis” The Franklin Institut Presse Philadelphia 509–525

    Google Scholar 

  • F Denis (1999) ArticleTitleControversy on the hepatitis B vaccine. Bull Soc Fr Microbiol 14 7–10

    Google Scholar 

  • E Marshall (1998) ArticleTitleA shadow falls on hepatitis B vaccination effort. Science 281 630–631 Occurrence Handle10.1126/science.281.5377.630 Occurrence Handle9714670 Occurrence Handle1:CAS:528:DyaK1cXltFegs7c%3D

    Article  PubMed  CAS  Google Scholar 

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Correspondence to François Denis.

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Denis, F., Ranger-Rogez, S., Alain, S. et al. Sreening of pregnant women for hepatitis B markers in a French Provincial University Hospital (Limoges) during 15 years. Eur J Epidemiol 19, 973–978 (2004).

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