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European Journal of Epidemiology

, Volume 19, Issue 11, pp 1011–1019 | Cite as

Some life-style factors and the risk of invasive epithelial ovarian cancer in Swedish women

  • Tomas Riman
  • Paul Dickman
  • Staffan Nilsson
  • Hans Nordlinder
  • Cecilia M. Magnusson
  • Ingemar R. Persson
Article

Abstract

The objective of this nationwide case-control study was to examine body mass index (BMI), alcohol use, coffee consumption, cigarette smoking, and leisure-time physical activity in relation to epithelial ovarian cancer (EOC) risk. Subjects were 655 newly diagnosed EOC cases and 3899 population controls, all 50-74 years of age at recruitment between 1993 and 1995. Data were collected through mailed questionnaires. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Women with a BMI ≥ 30 kg/m2 compared with those with a BMI < 22 kg/m2 appeared to have an elevated EOC risk (OR = 1.37, 95% CI: 1.01-1.85), particularly of mucinous (OR = 2.76, 95% CI: 1.15-6.61) and clear-cell histologies (OR = 2.68, 95% CI: 0.96-7.48). The OR for EOC among coffee users reporting ≥ 6 daily cups compared with non-users was 0.68 (95% CI: 0.42-1.10). Alcohol consumption was unrelated to EOC risk. Compared to non-smokers the ORs of EOC among current smokers were 0.70 (95% CI: 0.52-0.94) for those who smoked 1-10 cigarettes/day and 0.74 (95% CI: 0.53-1.02) for heavier smokers, while former smokers were at an unaltered risk (OR = 0.83, 95% CI: 0.66-1.04). Reduced EOC risks were observed among women in the highest compared with the lowest physical activity levels both at age 18-30 years (OR = 0.67, 95% CI: 0.52-0.87) and during the last years preceding study enrollment (OR = 0.68, 95% CI: 0.53-0.87). We conclude that women may avoid an excess risk of EOC through maintaining a normal BMI and reduce their risk by participation in leisure-time physical activity. The use of coffee, alcohol, or cigarette smoking does not appear␣to increase the risk of EOC.

Alcohol use Body mass index Coffee consumption Epithelial ovarian cancer Physical activity Smoking 

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Tomas Riman
    • 1
    • 2
    • 3
  • Paul Dickman
    • 2
  • Staffan Nilsson
    • 1
    • 2
  • Hans Nordlinder
    • 4
    • 5
  • Cecilia M. Magnusson
    • 2
  • Ingemar R. Persson
    • 2
  1. 1.Department of Obstetrics and Gynecology, Falu HospitalFalunSweden;(
  2. 2.Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden
  3. 3.Center for Clinical ResearchDalarnaSweden
  4. 4.Department of PathologyUppsala UniversityUppsalaSweden
  5. 5.Department of PathologySahlgrenska University HospitalGothenburgSweden

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