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Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in chilean subjects: A case-parent study

  • Diabetes Epidemiology
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Abstract

Several reports have found a relation between polymorphisms of the vitamin D receptor gene (VDR) and the development of type 1 diabetes. We have examined the association of three VDR polymorphism with type 1 diabetes in 59 Chilean case-parents trios. Genotyping for Bsm1, Apa1 and Taq1 polymorphism were performed. Transmission/disequiibrium tests were used to assess gene-disease associations through the evaluation of allelic transmission to affected offspring. Non-significant increased transmissions of B allele (probability of transmission=52.5, p=0.69), A allele (probability of transmission=58.4, p=0.17) and T allele (probability of transmission=52.0, p=0.77) were estimated in Bsm1, Apa1 and Taq1 sites, respectively. Haplotype-based analyses showed non-significant preferential transmissions (global p=0.52). The present study does not support the hypothesis of a significant contribution of VDR alleles in the etiology of type 1 diabetes of Chilean cases.

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Authors and Affiliations

  1. Genetic Epidemiology Laboratory, Nutrition and Food Technology Institute (INTA), University of Chile, P.O. Box 138-11, Santiago, Chile

    Bárbara Angel, José Luis Santos, Cecilia Albala & Francisco Pérez-Bravo

  2. Diabetes Unit, San Juan de Dios Hospital, Faculty of Medicine, University of Chile, Santiago, Chile

    Elena Carrasco

Authors
  1. Bárbara Angel
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  2. José Luis Santos
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  3. Elena Carrasco
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  4. Cecilia Albala
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  5. Francisco Pérez-Bravo
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Corresponding author

Correspondence to Francisco Pérez-Bravo.

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Angel, B., Santos, J.L., Carrasco, E. et al. Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in chilean subjects: A case-parent study. Eur J Epidemiol 19, 1085–1087 (2004). https://doi.org/10.1007/s10654-004-1026-z

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