Abstract
Asthma is a common chronic heterogeneous disease. Outdoor air pollutants are an important cause of acute asthma. Until now, the association between the risk of acute asthma and outdoor air pollutants is unclear. And the relationship between the different phenotypes of asthma and outdoor air pollutants has not been reported. Thus, an analysis of the association between outdoor air pollutants and daily acute asthma inpatient and outpatient visits in Xi’an, China, from January 1 to December 31, 2018, was conducted. A total of 3395 people were included in the study. The statistical analysis and relational analysis based on the logistic regression were used for illustrating the relatedness of the acute asthma risk factor and phenotype with outdoor air pollutants, while the age, gender, pollen peak and non-pollen peak periods, high type 2 (T2) asthma and non-high T2 asthma were also stratified. Results showed that particulate matter with particle size below 10 μm and 2.5 μm (PM10 and PM2.5), sulfur dioxide(SO2), nitrogen dioxide(NO2), and carbon monoxide(CO) increase the risk of acute asthma and that air pollutants have a lagged effect on asthma patients. PM10, NO2, CO, and Ozone (O3) are associated with an increased risk of acute attacks of high T2 asthma. PM10, PM2.5, SO2, NO2 and CO are associated with an increased risk of acute asthma in males of 0–16 years old. PM10 and PM2.5 are more harmful to asthma patients with abnormal lung function.
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The datasets used in the study are available from the corresponding author on reasonable request.
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This work was supported by the National Natural Science Foundation of China (grant number 82070035, 81770037).
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All the authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by YL, XJ, FZ, DW, HD, HL, HZ, JH, JL, XF, and YL. The first draft of the manuscript was written by YL and XJ. YL and XJ contributed equally to this work and should be considered co-first authors. No conflict of interest exists in submitting this manuscript, and the manuscript is approved by all authors for publication and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript.
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Lu, Y., Jie, X., Zou, F. et al. Investigation analysis of the acute asthma risk factor and phenotype based on relational analysis with outdoor air pollutants in Xi’an, China. Environ Geochem Health 46, 75 (2024). https://doi.org/10.1007/s10653-023-01816-0
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DOI: https://doi.org/10.1007/s10653-023-01816-0