Abstract
Hypertension has long been recognized as the global health burden. Heavy metal pollution may be one of the environmental risk factors of hypertension. However, the association remains unclear. We studied the levels of aluminum (Al), vanadium (V), manganese (Mn), arsenic (As), selenium (Se), strontium (Sr), barium (Ba), titanium (Ti), lead (Pb) and cobalt (Co) in whole blood, and the relationship between trace element exposure and hypertension in the elderly community-based Chinese population. A total of 1013 participants from the west of Anhui Province in China were consecutively enrolled in this study in 2016. The general sociodemographic characteristics, lifestyles, disease history and physical examination information were collected by face-to-face survey and physical examination. The levels of ten trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS). Multivariable logistic regression model was used to assess the association of trace element exposure with the risk of hypertension. Results showed that the odds ratio of hypertension in the highest quartile was 1.811 (95% CI 1.175–2.790, P trend = 0.005) and 1.772 (95% CI 1.121–2.800, P trend = 0.022), respectively, after adjusting for potential confounders, as compared with the lowest quartile of blood Pb and Sr levels.
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The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Acknowledgements
We thank all participants in this study, including the Lu’an Center for Disease Control and Prevention, Cheng bei Township Health Center and Bei shi community health service center. This work was supported by National Natural Science Foundation of China (No. 81102125) and the Grants for Major Projects on College Leading Talent Team Introduced of Anhui (0303011224).
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This study was supported by National Natural Science Foundation of China (No. 81102125) and Grants for Scientific Research of BSKY (Serial Number: XJ201705) from Anhui Medical University.
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SW and JZ had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. SW and JS contributed to study concept and design. All authors contributed to investigation, analysis or interpretation of data. JZ, XY, CX and YG drafted the manuscript. JS, XJ and Qi Tao contributed to measurement of trace elements. FT contributed to study supervision. SW, CX and JS critically revised the manuscript.
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Zhang, J., Xu, C., Guo, Y. et al. Increased hypertension risk for the elderly with high blood levels of strontium and lead. Environ Geochem Health 45, 1877–1888 (2023). https://doi.org/10.1007/s10653-022-01317-6
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DOI: https://doi.org/10.1007/s10653-022-01317-6