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Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium

Ecotoxicology volume 26, pages 74–80 (2017)Cite this article

Abstract

Cadmium (Cd) is one of the most important metal contaminants in the Bohai Sea. In this work, NMR-based metabolomics was used to investigate the toxicological effects of Cd at an environmentally relevant concentration (50 µg L−1) in three different life stages (D-shape larval, juvenile and adult) of mussels Mytilus galloprovincialis. Results indicated that the D-shape larval mussel was the most sensitive life stage to Cd. The significantly different metabolic profiles meant that Cd induced differential toxicological effects in three life stages of mussels. Basically, Cd caused osmotic stress in all the three life stages via different metabolic pathways. Cd exposure reduced the anaerobiosis in D-shape larval mussels and disturbed lipid metabolism in juvenile mussels, respectively. Compared with the D-shape larval and juvenile mussels, the adult mussels reduced energy consumption to deal with Cd stress.

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Acknowledgments

This work was supported by NSFC (41676114) and Natural Science Foundation of Shandong Province (No. JQ201310). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Prof. Mark Viant (School of Bioscience, The University of Birmingham) for the use of ProMetab software.

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Affiliations

  1. Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, YICCAS, Yantai, 264003, P. R. China

    Huifeng Wu, Lanlan Xu, Deliang Yu & Chenglong Ji

  2. University of Chinese Academy of Sciences, Beijing, 100049, P. R. China

    Lanlan Xu & Deliang Yu

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  1. Huifeng Wu
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  2. Lanlan Xu
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  3. Deliang Yu
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  4. Chenglong Ji
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Correspondence to Huifeng Wu.

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Wu, H., Xu, L., Yu, D. et al. Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium. Ecotoxicology 26, 74–80 (2017). https://doi.org/10.1007/s10646-016-1741-8

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  • DOI: https://doi.org/10.1007/s10646-016-1741-8

Keywords

  • Mytilus galloprovincialis
  • Cadmium
  • Toxicological effects
  • NMR
  • Metabolomics