Summary
Osimertinib is a key drug for cancer patients with EGFR mutations. However, there is little information about its safety in cancer patients who require hemodialysis (HD) for chronic renal failure, despite notable increases in their numbers. Herein, we examined osimertinib safety in such a patient via pharmacokinetics analysis. A 66-year-old man was diagnosed with relapsed stage IV non-small cell lung cancer with an EGFR mutation in exon 21 (L858R) 2 years after stereotactic body radiotherapy. He was undergoing HD three times a week owing to worsening diabetic nephropathy. We administered osimertinib (80 mg/day) as the first-line therapy. We measured osimertinib concentrations on multiple days, either before, after, or in the absence of HD. Maximum concentrations and areas under the curve were determined. We found that HD did not affect the pharmacokinetics of osimertinib. We conclude that osimertinib can be safely administered to cancer patients undergoing HD.
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The authors thank Keiko Sakuragawa for administrative assistance.
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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Atsushi Matsunashi, Daichi Fujimoto, Kazutaka Hosoya and Kei Irie. The first draft of the manuscript was written by Atsushi Matsunashi, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Dr. Fujimoto and Dr. Hosoya received lecture fees from AstraZeneca. All the remaining authors have declared no conflicts of interest.
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Matsunashi, A., Fujimoto, D., Hosoya, K. et al. Osimertinib in a patient with non-small cell lung cancer and renal failure undergoing hemodialysis: a case report. Invest New Drugs 38, 1192–1195 (2020). https://doi.org/10.1007/s10637-019-00851-y
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DOI: https://doi.org/10.1007/s10637-019-00851-y