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Lung cancer and β-glucans: review of potential therapeutic applications

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Summary

The potential of natural substances with immunotherapeutic properties has long been studied. β-glucans, a cell wall component of certain bacteria and fungi, potentiate the immune system against microbes and toxic substances. Moreover, β-glucans are known to exhibit direct anticancer effects and can suppress cancer proliferation through immunomodulatory pathways. Mortality of lung cancer has been alarmingly increasingly worldwide; therefore, treatment of lung cancer is an urgent necessity. Numerous researchers are now dedicated to using β-glucans as a therapy for lung cancer. In the present attempt, we have reviewed the studies addressing therapeutic effects of β-glucans in primary and metastatic lung cancer published in the time period of 1991–2016.

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Authors and Affiliations

  1. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran

    Raheleh Roudi

  2. Department of Medical Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Shahla Roudbar Mohammadi

  3. Department of Medical Mycology and Parasitology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Maryam Roudbary

  4. Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

    Monireh Mohsenzadegan

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  1. Raheleh Roudi
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Correspondence to Maryam Roudbary or Monireh Mohsenzadegan.

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Raheleh Roudi declares that she has no conflict of interest.

Shahla Roudbar Mohammadi declares that she has no conflict of interest.

Maryam Roudbary declares that she has no conflict of interest.

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Roudi, R., Mohammadi, S.R., Roudbary, M. et al. Lung cancer and β-glucans: review of potential therapeutic applications. Invest New Drugs 35, 509–517 (2017). https://doi.org/10.1007/s10637-017-0449-9

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  • DOI: https://doi.org/10.1007/s10637-017-0449-9

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