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Hydrogen sulfide down-regulates the expression and release of osteoprotegerin (OPG) by vascular endothelial cells

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References

  1. 1.

    Simonet WS, Lacey DL, Dunstan C et al (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309–319

    Article  CAS  PubMed  Google Scholar 

  2. 2.

    Milani D, Zauli G, Rimondi E et al (2003) Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in sk-n-mc neuronal cells. J Neurochem 86:126–135

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    DI Pietro R, Zauli G (2004) Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L. J Cell Physiol 201:331–340

    Article  PubMed  Google Scholar 

  4. 4.

    Zauli G, Melloni E, Capitani S, Secchiero P (2009) Role of full-length osteoprotegerin in tumor cell biology. Cell Mol Life Sci 66:841–851

    Article  CAS  PubMed  Google Scholar 

  5. 5.

    Secchiero P, Corallini F, Pandolfi A et al (2006) An increased osteoprotegerin (OPG) serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction. Am J Pathol 169:2236–2244

    Article  CAS  PubMed  Google Scholar 

  6. 6.

    Navarra P, Dello Russo C, Mancuso C, Preziosi P, Grossman A (2000) Gaseous neuromodulators in the control of neuroendocrine stress axis. Ann NY Acad Sci 917:638–646

    Article  CAS  PubMed  Google Scholar 

  7. 7.

    Wang R (2002) Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J 16:1792–1798

    Article  CAS  PubMed  Google Scholar 

  8. 8.

    Moore PK, Bhatia M, Moochhala S (2003) Hydrogen sulfide: from the smell of the past to the gas of the future? Trends Pharmacol Sci 24:609–611

    Article  CAS  PubMed  Google Scholar 

  9. 9.

    Secchiero P, Candido R, Corallini F et al (2006) Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation 114:1522–1530

    Article  CAS  PubMed  Google Scholar 

  10. 10.

    Secchiero P, Corallini F, Gonelli A et al (2007) Anti-angiogenic activity of the MDM2 antagonist nutlin-3. Circ Res 100:61–69

    Article  CAS  PubMed  Google Scholar 

  11. 11.

    Re MC, Zauli G, Gibellini D et al (1993) Uninfected haematopoietic progenitor (CD34+) cells purified from the bone marrow of aids patients are committed to apoptotic cell death in culture. AIDS 7:1049–1055

    Article  CAS  PubMed  Google Scholar 

  12. 12.

    Zauli G, Re MC, Furlini G, Giovannini M, LA Placa M (1992) Human immunodeficiency virus type 1 envelope glycoprotein GP120-mediated killing of human haematopoietic progenitors (CD34+ cells). J Gen Virol 73:417–421

    Article  CAS  PubMed  Google Scholar 

  13. 13.

    Zauli G, Rimondi E, Stea S et al (2008) Trail inhibits osteoclastic differentiation by counteracting rankl-dependent P27KIP1 accumulation in pre-osteoclast precursors. J Cell Physiol 214:117–125

    Article  CAS  PubMed  Google Scholar 

  14. 14.

    Mangan SH, Campenhout AV, Rush C, Golledge J (2007) Osteoprotegerin upregulates endothelial cell adhesion molecule response to tumor necrosis factor-alpha associated with induction of angiopoietin-2. Cardiovasc Res 76:494–505

    Article  CAS  PubMed  Google Scholar 

  15. 15.

    Zauli G, Corallini F, Bossi F et al (2007) Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo. Blood 110:536–543

    Article  CAS  PubMed  Google Scholar 

  16. 16.

    Cross SS, Yang Z, Brown NJ et al (2006) Osteoprotegerin (OPG)–a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis? Int J Cancer 118:1901–1908

    Article  CAS  PubMed  Google Scholar 

  17. 17.

    Li L, Moore P (2008) Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air? Trends Pharmacol Sci 29:84–90

    Article  PubMed  Google Scholar 

  18. 18.

    Szabó C (2007) Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6:917–993

    Article  PubMed  Google Scholar 

  19. 19.

    Secchiero P, Corallini F, DI Iasio MG, Gonelli A, Barbarotto E, Zauli G (2005) Trail counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release. Blood 105:3413–3419

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by a grant from FoRST—Fondazione per la Ricerca Scientifica Termale to GZ.

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Correspondence to Giorgio Zauli.

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Rimondi, E., di Iasio, M.G., Gonelli, A. et al. Hydrogen sulfide down-regulates the expression and release of osteoprotegerin (OPG) by vascular endothelial cells. Invest New Drugs 30, 1731–1735 (2012). https://doi.org/10.1007/s10637-011-9675-8

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Keywords

  • Human Umbilical Vein Endothelial Cell
  • NaHS
  • Cystathionine
  • Endothelial Cell Dysfunction
  • Human Umbilical Vein Endothelial Cell Culture