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Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™

Investigational New Drugs volume 23, pages 121–122 (2005)Cite this article

An Erratum to this article was published on 01 August 2005

Summary

Four pure chemicals, ellagic acid (E), caffeic acid (C), luteolin (L) and punicic acid (P), all important components of the aqueous compartments or oily compartment of pomegranate fruit (Punica granatum), and each belonging to different representative chemical classes and showing known anticancer activities, were tested as potential inhibitors of in vitro invasion of human PC-3 prostate cancer cells in an assay employing Matrigel™ artificial membranes. All compounds significantly inhibited invasion when employed individually. When C, P, and L were equally combined at the same gross dosage (4 μ g/ml) as when the compounds were tested individually, a supradditive inhibition of invasion was observed, measured by the Kruskal-Wallis non-parametric test.

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Authors and Affiliations

  1. Rimonest Ltd., P.O.B. 9945, Haifa, Israel

    Ephraim Philip Lansky (MD, Scientific Director)

  2. Metastasis and Angiogenesis Research Group, University of Wales, College of Medicine, Cardiff, UK

    Gregory Harrison & Wen G. Jiang

  3. Department of Epidemiology and Preventive Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Paul Froom

  4. Rimonest Ltd., Horev Center, Box 9945, Haifa, Israel

    Ephraim Philip Lansky (MD, Scientific Director)

Authors
  1. Ephraim Philip Lansky
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  2. Gregory Harrison
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  3. Paul Froom
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  4. Wen G. Jiang
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Corresponding author

Correspondence to Ephraim Philip Lansky.

Additional information

An erratum to this article can be found athttp://dx.doi.org/10.1007/s10637-005-2500-5

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Lansky, E.P., Harrison, G., Froom, P. et al. Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™. Invest New Drugs 23, 121–122 (2005). https://doi.org/10.1007/s10637-005-5856-7

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  • DOI: https://doi.org/10.1007/s10637-005-5856-7

Key words

  • caffeic acid
  • conjugated fatty acid
  • ellagic acid
  • luteolin
  • punicic acid