Investigational New Drugs

, Volume 24, Issue 3, pp 177–180 | Cite as

Pre-irradiation 9-Amino [20s] camptothecin (9-AC) in patients with newly diagnosed glioblastoma multiforme

  • Daniel Farray
  • Manmeet S. Ahluwalia
  • Josette Snyder
  • Gene H. Barnett
  • Bruce H. Cohen
  • John H. Suh
  • David M. PeereboomEmail author
Preclinical Studies


Purpose: To evaluate the efficacy of 9-amino [20s] camptothecin (9-AC) given before radiation therapy to patients with newly diagnosed glioblastoma multiforme (GBM). Methods: Eligible patients had newly diagnosed GBM who had residual measurable contrast-enhancing tumor. The trial was a phase 2 trial of 9-AC at 1100 μg/m2 /24 h infused over 72 h every two weeks for up to six cycles in patients with newly diagnosed GBM before radiation therapy. Results: Fourteen patients entered the study and all were evaluable. All of the patients had progressive disease by imaging criteria after at least two cycles of 9-AC (1 month). The median overall survival was 7.5 months (range 1.5–18 months). The most common adverse event was transient lymphopenia (grade 3–4). One patient developed grade 4 neutropenic fever that resolved after three days of diagnosis. Conclusions: 9-AC lacks activity against glioblastoma multiforme (GBM). Further studies looking at the efficacy of 9-AC in GBM may be futile.

Key Words

camptothecin glioblastoma multiforme high grade astrocytomas chemotherapy 


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Copyright information

© Springer Science + Business Media, LLC 2005

Authors and Affiliations

  • Daniel Farray
    • 1
  • Manmeet S. Ahluwalia
    • 2
  • Josette Snyder
    • 3
  • Gene H. Barnett
    • 3
  • Bruce H. Cohen
    • 3
  • John H. Suh
    • 3
  • David M. Peereboom
    • 3
    Email author
  1. 1.Loyola University Medical CenterMaywood
  2. 2.Roswell Park Cancer CenterBuffalo
  3. 3.Cleveland Clinic Brain Tumor InstituteCleveland

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