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Multifocal electroretinography in patients with macular telangiectasia type 2

Documenta Ophthalmologica volume 141, pages 15–21 (2020)Cite this article

Abstract

Purpose

To evaluate the multifocal electroretinographic (mfERG) response in patients with macular telangiectasia (MacTel) type 2.

Methods

Prospective, observational case series. Thirty-four eyes of 18 patients diagnosed with nonproliferative MacTel type 2 underwent recording of best-corrected visual acuity (BCVA), fundus fluorescein angiography, spectral domain optical coherence tomography (SD-OCT) and mfERG using 61 hexagonal elements, in accordance with ISCEV guidelines. The P1 average response densities and implicit times of the first-order kernel responses were grouped into five concentric rings centred on the fovea. Data from the left eyes of cases (18 eyes) were compared with 34 eyes of age- and sex-matched controls. Correlation analyses were performed between BCVA, mfERG parameters and SD-OCT measurements.

Results

Mean BCVA of the cases was 0.3 ± 0.26 ranging from 0 to 1. On SD-OCT, mean central foveal thickness was 205.78 ± 40.92 μm and average mean macular thickness was 248.22 ± 23.08 μm. Mean P1 amplitudes were significantly decreased in eyes with MacTel type 2 as compared to controls in ring 1 (p = 0.039). Mean P1 implicit time in all the rings was comparable between the two groups. BCVA was significantly and negatively correlated with P1 amplitude in ring 1 (r = − 0.518, p = 0.028) in eyes with MacTel type 2.

Conclusion

mfERG reflects localised inner retinal dysfunction in MacTel type 2. Correlation with BCVA reinforces that mfERG should be used to objectively assess the macular function in these patients.

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Funding

No funding was received for this research.

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Affiliations

  1. ICARE Eye Hospital and Postgraduate Institute, Noida, U.P., India

    Neha Goel, Anjula Kumari, Satish Kumar & Aanchal Mehta

  2. Eye7 chaudhary eye centre, Daryaganj, New Delhi, India

    Neha Goel

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  1. Neha Goel
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  2. Anjula Kumari
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  3. Satish Kumar
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  4. Aanchal Mehta
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Correspondence to Neha Goel.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of ICARE eye hospital and postgraduate institute, Noida, UP, India, and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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The procedures followed in this study in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 and 2008.

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Goel, N., Kumari, A., Kumar, S. et al. Multifocal electroretinography in patients with macular telangiectasia type 2. Doc Ophthalmol 141, 15–21 (2020). https://doi.org/10.1007/s10633-019-09746-y

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  • DOI: https://doi.org/10.1007/s10633-019-09746-y

Keywords

  • Multifocal electroretinography
  • Idiopathic macular telangiectasia
  • Macular telangiectasia type 2
  • Spectral domain optical coherence tomography
  • Müller cells