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Evaluation of pattern electroretinogram in retinal vein occlusion treated with intravitreal triamcinolone acetonide

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Abstract

Purpose

To evaluate pattern electroretinogram (pattern ERG) and anatomical changes in optical coherence tomography (OCT) in acute retinal vein occlusion with macular oedema after intravitreal triamcinolone acetonide (IVTA) injection.

Methods

In this prospective interventional study, 20 patients with acute retinal vein occlusion (branch and central) of less than 1 month duration were evaluated for pattern ERG, best-corrected visual acuity (BCVA), central macular thickness on OCT, and contrast sensitivity (CS) before and 1, 6 and 12 weeks after 1 mg IVTA injection.

Results

The amplitude of P50 wave (pattern ERG) improved from 3.01 ± 1.22 to 3.56 ± 1.29 µv, mean logMAR BCVA improved from 1.10 ± 0.60 to 0.69 ± 0.45, and CS improved from 0.45 ± 0.41 to 0.79 ± 0.29; mean central macular thickness (CMT) decreased from 515.35 ± 202.83 to 358.35 ± 135.4µ at 12 weeks. All the values were statistically significant (p value < 0.001).

Conclusion

IVTA injection in acute retinal vein occlusion with macular oedema results in electrophysiological (pattern ERG) improvement in addition to anatomical (OCT) improvement.

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Authors and Affiliations

  1. Guru Nanak Eye Centre, Maulana Azad Medical College, Maharaja Ranjit Singh Marg, New Delhi, 110002, India

    Jawahar Lal Goyal, Richa Agarwal, Ritu Arora, Pooja Jain & Basudeb Ghosh

Authors
  1. Jawahar Lal Goyal
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  2. Richa Agarwal
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  3. Ritu Arora
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  4. Pooja Jain
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  5. Basudeb Ghosh
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Corresponding author

Correspondence to Pooja Jain.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Statement of human rights

The study was performed in accordance with Universal Declaration of Human Rights.

Statement on the welfare of animals

This article does not contain any studies with animals performed by any of the authors.

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Goyal, J., Agarwal, R., Arora, R. et al. Evaluation of pattern electroretinogram in retinal vein occlusion treated with intravitreal triamcinolone acetonide. Doc Ophthalmol 132, 167–175 (2016). https://doi.org/10.1007/s10633-016-9536-z

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  • DOI: https://doi.org/10.1007/s10633-016-9536-z

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