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Motion and pattern cortical potentials in adults with high-functioning autism spectrum disorder

Documenta Ophthalmologica volume 125, pages 219–227 (2012)Cite this article

Abstract

Purpose

Autism spectrum disorder (ASD) is a condition in which visual perception to both static and moving stimuli is altered. The aim of this study was to investigate the early cortical responses of subjects with ASD to simple patterns and moving radial rings using visual evoked potentials (VEPs).

Methods

Male ASD participants (n = 9) and typically developing (TD) individuals (n = 7) were matched for full, performance and verbal IQ (p > 0.263). VEPs were recorded to the pattern reversing checks of 50′ side length presented with Michelson contrasts of 98 and 10 % and to the onset of motion—either expansion or contraction of low-contrast concentric rings (33.3 % duty cycle at 10 % contrast).

Results

There were no significant differences between groups in the VEPs elicited by pattern reversal checkerboards of high (98 %) or low (10 %) contrast. The ASD group had a significantly larger N160 peak (1.85 x) amplitude to motion onset VEPs elicited by the expansion of radial rings (p = 0.001). No differences were evident in contraction VEP peak amplitudes nor in the latencies of the motion onset N160 peaks. There was no evidence of a response that could be associated with adaptation to the motion stimulus in the interstimulus interval following an expansion or contraction phase of the rings.

Conclusion

These data support a difference in processing of motion onset stimuli in this adult high-functioning ASD group compared to the TD group.

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Fig. 1

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Acknowledgments

This work was funded by the College of Optometrists UK. The author (PAC) is a College of Optometrists Research Fellowship. Parts of this work were presented at ISCEV 2011, Quebec. We would thank the participants for their time whilst carrying out this study. We would like to thank Dr Alki Liasis and Dr Say Soriano for advice on MRI segmentation and field analysis. Thank you to the two anonymous reviewers for their helpful suggestions on this manuscript.

Conflict of interest

The author declares no conflict of interest.

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Authors and Affiliations

  1. Division of Optometry, City University London, Northampton Square, London, EC1V 0HB, UK

    Paul A. Constable

  2. Department of Psychology, City University London, Autism Research Group, Social Sciences Building, Northampton Square, London, EC1V 0HB, UK

    Paul A. Constable, Sebastian B. Gaigg & Dermot M. Bowler

  3. Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children, London, WC1N 3JH, UK

    Dorothy A. Thompson

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  1. Paul A. Constable
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Correspondence to Paul A. Constable.

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Constable, P.A., Gaigg, S.B., Bowler, D.M. et al. Motion and pattern cortical potentials in adults with high-functioning autism spectrum disorder. Doc Ophthalmol 125, 219–227 (2012). https://doi.org/10.1007/s10633-012-9349-7

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Keywords

  • Autism spectrum disorder
  • Motion onset
  • Pattern reversal
  • VEPs
  • Contrast