Abstract
This study aimed to investigate the within-participant variability over time of both amplitude and peak latency measures of pattern reversal visual evoked potentials (pVEPs). As a large number of factors are known to contribute to the variability of the pVEPs (such as fixation instability and drowsiness), testing was conducted in controlled conditions with two co-operative participants. PVEPs were recorded during 24 sessions, over an eight-week period using the same equipment and recording settings. The participants viewed a plasma monitor binocularly from a distance of 1 meter. High contrast (97%), black and white checks of side subtense 50′, 25′, and 12.5′ pattern reversed 3/s in a 28 degree test field. The different sized checks were presented in a pseudo-random order. Three runs, each of 100 trials, were acquired to each stimulus from an active electrode placed at Oz referred to aFz. The amplitude of N80-P100 and the latency of P100 were measured. P100 amplitude and latency were stable across sessions and did not depend upon the order of check size presentation. As expected, variation in amplitude was greater than peak latency. The coefficients of variation for different check sizes and participants were 9–14% for pVEP amplitude, but only 1–2% for P100 latency.
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References
Sokol S (1976) Visually evoked potentials: theory, techniques and clinical applications. Surv Ophthalmol 21:18–44
Harding GF (2006) History of visual evoked cortical testing. In: Heckenlively JR, Arden GB (eds) Principles and practice of clinical electrophysiology of vision, 2nd edn. MIT Press, London, pp 15–19
Halliday AM (1978) Clinical applications of evoked potentials. In: Matthews WB, Glaser GH (eds) Recent advances in clinical neurology, 2nd edn. Churchill Livingstone, London, pp 47–73
Trip SA, Schlottmann PG, Jones SJ, Wai-Yung L, Garway-Heath DF, Thompson AJ, Plant GT, Miller DH (2006) Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy. Neuroimage 31:286–293
Brusa A, Jones SJ, Plant GT (2001) Long-term remyelination after optic neuritis: A 2-year visual evoked potential and psychophysical serial study. Brain 124:468–479
Levi DM (1982) Do visual evoked potentials studies reveal amblyopic abnormalities not readily apparent in psychophysical tests? Ann N Y Acad Sci 388:615–621
Oner A, Coskun M, Evereklioglu C, Dogan H (2004) Pattern VEP is a useful technique in monitoring the effectiveness of occlusion therapy in amblyopic eyes under occlusion therapy. Doc Ophthalmol 109:223–227
Liasis A, Nischal KK, Walters B, Thompson D, Hardy S, Towell A, Dunaway D, Jones B, Evans R, Hayward R (2006) Monitoring visual function in children with syndromic craniosynostosis: a comparison of three methods. Arch Ophthalmol 124:1119–1126
Hidajat RR, McLay JL, Goode DH, Hidayat JR (2006) The value of VEP in the diagnosis and post-operative monitoring of meningioma. Doc Ophthalmol 113:165–169
Moradi P, Robson AG, Rose GE, Holder GE (2008) Electrophysiological monitoring in a patient with an optic nerve glioma. Doc Ophthalmol 117:171–174
Taylor MJ, McCulloch DL (1992) Visual evoked potentials in infants and children. J Clin Neurophysiol 9:357–372
Meienberg O, Kutak L, Smolenski C, Ludin HP (1979) Pattern reversal evoked cortical responses in normals: a study of different methods of stimulation and potential reproducibility. J Neurol 222:81–93
Diener HC, Scheibler H (1980) Follow-up studies of visual potentials in multiple sclerosis evoked by checkerboard and foveal stimulation. Electroencephalogr Clin Neurophysiol 49:490–496
de Weerd AW, Jonkman EJ (1982) Changes in visual and short-latency somatosensory evoked potentials in patients with multiple sclerosis. In: Courjon J, Mauguiere F, Revol M (eds) Advances in Neurology: Clinical applications of evoked potentials in neurology. Raven Press, New York, pp 527–534
Cohen SN, Syndulko K, Hansch E, Tourtellotte WW, Potvin AR (1982) Variability on serial testing of visual evoked potentials in patients with multiple sclerosis. In: Courjon J, Mauguiere F, Revol M (eds) Advances in Neurology: Clinical applications of evoked potentials in neurology. Raven Press, New York, pp 559–565
Aminoff MJ, Davis SL, Panitch HS (1984) Serial evoked potential studies in patients with definite multiple sclerosis. Arch Neurol 41:1197–1202
Becker WJ, Richards IM (1984) Serial pattern shift visual evoked potentials in multiple sclerosis. Can J Neurol Sci 11:53–59
Skuse NF, Burke D, McKeon B (1984) Reproducibility of the visual evoked potential using a light-emitting diode stimulator. J Neurol Neurosurg Psychiatry 47:623–629
Carroll WM, Barrett G, Halliday AM (1985) Unidirectional preponderance of P100 latency changes in a serial VEP study of multiple sclerosis. Electroencephalogr Clin Neurophysiol 61:S210
Hammond SR, MacCallum S, Yiannikas C, Walsh JC, McLeod JG (1987) Variability on serial testing of pattern reversal visual evoked potential latencies from full-field, half-field and foveal stimulation in control subjects. Electroencephalogr Clin Neurophysiol 66:401–408
Oken BS, Chiappa KH, Gill E (1987) Normal temporal variability of the P100. Electroencephalogr Clin Neurophysiol 68:153–156
Shors TJ, Ary JP, Eriksen KJ, Wright KW (1986) P100 amplitude variability of the pattern visual evoked potential. Electroencephalogr Clin Neurophysiol 65:316–319
Halliday AM, Halliday E, Kriss A, McDonald WI, Mushin J (1976) The pattern-evoked potential in compression of the anterior visual pathways. Brain 99:357–374
Otto T, Bach M (1997) Reproducibility of the pattern electroretinogram. Ophthalmologe 94:217–221
Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL, Tormene AP, Vaegan (2010) ISCEV standard for clinical visual evoked potentials (2009 update). Doc Ophthalmol 120:111–119
Wolery M, Harris SR (1982) Interpreting results of single-subject research designs. Phys Ther 62:445–452
Sarnthein J, Andersson M, Zimmermann MB, Zumsteg D (2009) High test-retest reliability of checkerboard reversal visual evoked potentials (VEP) over 8 months. Clin Neurophysiol 120:1835–1840
Sokol S, Moskowitz A, Towle VL (1981) Age-related changes in the latency of the visual evoked potential: influence of check size. Electroencephalogr Clin Neurophysiol 51:559–562
Torok B, Meyer M, Wildberger H (1992) The influence of pattern size on amplitude, latency and wave form of retinal and cortical potentials elicited by checkerboard pattern reversal and stimulus onset-offset. Electroencephalogr Clin Neurophysiol 84:13–19
Morgan RK, Nugent B, Harrison JM, O’Connor PS (1985) Voluntary alteration of pattern visual evoked responses. Ophthalmology 92:1356–1363
Skuse NF, Burke D (1992) Sequence-dependent deterioration in the visual evoked potential in the absence of drowsiness. Electroencephalogr Clin Neurophysiol 84:20–25
Joost W, Bach M, Schulte-Monting J (1992) Influence of mood on visually evoked potentials: a prospective longitudinal study. Int J Psychophysiol 12:147–153
Stolz G, Aschoff JC, Born J, Aschoff J (1988) VEP, physiological and psychological circadian variations in humans. J Neurol 235:308–313
Cant BR, Hume AL, Shaw NA (1978) Effects of luminance on the pattern visual evoked potential in multiple sclerosis. Electroencephalogr Clin Neurophysiol 45:496–504
Binnie CD, Rowan AJ, Gutter TH (1982) A manual of electroencephalographic technology. Cambridge University Press, Cambridge
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The authors are grateful to Phillippa Cumberland for her statistical advice.
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Mellow, T.B., Liasis, A., Lyons, R. et al. The reproducibility of binocular pattern reversal visual evoked potentials: a single subject design. Doc Ophthalmol 122, 133–139 (2011). https://doi.org/10.1007/s10633-011-9267-0
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DOI: https://doi.org/10.1007/s10633-011-9267-0