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Transitions of multifocal electroretinography in patients with age-related macular degeneration after combination therapy with photodynamic therapy and intravitreal bevacizumab

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Abstract

To evaluate by multifocal electroretinograms (mfERG) the macular function before and after combined treatment with photodynamic therapy (PDT) and intravitreal bevacizumab in eyes suffering from choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). 15 eyes of 15 patients with subfoveal CNV were studied before and after the combined treatment. The post-treatment follow-up was 6 months. MfERG recordings were performed in each patient before and 1, 3, and 6 months after the treatment. The mean N1 response amplitudes tended to increase after the treatment, and ring 2 response amplitude was significantly increased at 3 and 6 months compared to baseline (P = 0.033, 0.005, respectively). For mean P1 response amplitudes, there was a significant increase in retinal response amplitudes in ring 1–3 at 6 months (P = 0.036, 0.013, 0.008, respectively). No statistically significant difference in both mean N1 and P1 latency was observed for any ring over the course of treatment. PDT combined with intravitreal bevacizumab can increase the response amplitudes of mfERG in neovascular AMD patients.

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References

  1. Klein R, Klein BE, Jensen SC, Meuer SM (1997) The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 104:7–21

    CAS  PubMed  Google Scholar 

  2. Kaiser PK (2006) Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group. Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: 5-year results of two randomized clinical trials with an open-label extension: TAP report no. 8. Graefes Arch Clin Exp Ophthalmol 244:1132–1142

    Google Scholar 

  3. Matsuoka M, Ogata N, Otsuji T, Nishimura T, Takahashi K, Matsumura M (2004) Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy. Br J Ophthalmol 88:809–815

    Article  CAS  PubMed  Google Scholar 

  4. Schmidt-Erfurth U, Schlötzer-Schrehard U, Cursiefen C, Michels S, Beckendorf A, Naumann GO (2003) Influence of photodynamic therapy on expression of vascular endothelial growth factor (VEGF), VEGF receptor 3, and pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 44:4473–4480

    Article  PubMed  Google Scholar 

  5. Ladas ID, Kotsolis AI, Papakostas TD, Rouvas AA, Karagiannis DA, Vergados I (2007) Intravitreal bevacizumab combined with photodynamic therapy for the treatment of occult choroidal neovascularization associated with serous pigment epithelium detachment in age-related macular degeneration. Retina 27:891–896

    Article  PubMed  Google Scholar 

  6. Costa RA, Jorge R, Calucci D, Melo LA Jr, Cardillo JA, Scott IU (2007) Intravitreal bevacizumab (Avastin) in combination with verteporfin photodynamic therapy for choroidal neovascularization associated with age-related macular degeneration (IBeVe Study). Graefes Arch Clin Exp Ophthalmol 245:1273–1280

    Article  CAS  PubMed  Google Scholar 

  7. Smith BT, Dhalla MS, Shah GK, Blinder KJ, Ryan EH Jr, Mittra RA (2008) Intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy for choroidal neovascularization in age-related macular degeneration. Retina 28:675–681

    Article  PubMed  Google Scholar 

  8. Weigert G, Michels S, Sacu S, Varga A, Prager F, Geitzenauer W, Schmidt-Erfurth U (2008) Intravitreal bevacizumab (Avastin) therapy versus photodynamic therapy plus intravitreal triamcinolone for neovascular age-related macular degeneration: 6-month results of a prospective, randomised, controlled clinical study. Br J Ophthalmol 92:356–360

    Article  CAS  PubMed  Google Scholar 

  9. Lazic R, Gabric N (2007) Verteporfin therapy and intravitreal bevacizumab combined and alone in choroidal neovascularization due to age-related macular degeneration. Ophthalmology 114:1179–1185

    Article  PubMed  Google Scholar 

  10. Feigl B, Lovie-Kitchin J, Brown B (2005) Objective functional assessment of age-related maculopathy: a special application for the multifocal electroretinogram. Clin Exp Optom 88:304–312

    Article  PubMed  Google Scholar 

  11. Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group (1999) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials–TAP report. Arch Ophthalmol 117:1329–1345

    Google Scholar 

  12. Hood DC, Bach M, Brigell M et al (2008) ISCEV guidelines for clinical multifocal electroretinography (2007 edition). Doc Ophthalmol 116:1–11

    Article  PubMed  Google Scholar 

  13. Jurklies B, Weismann M, Hüsing J, Sutter EE, Bornfeld N (2002) Monitoring retinal function in neovascular maculopathy using multifocal electroretinography—early and long-term correlation with clinical findings. Graefes Arch Clin Exp Ophthalmol 240:244–264

    Article  CAS  PubMed  Google Scholar 

  14. Mackay AM, Brown MC, Hagan RP, Fisher AC, Grierson I, Harding SP (2007) Deficits in the electroretinogram in neovascular age-related macular degeneration and changes during photodynamic therapy. Doc Ophthalmol 115:69–76

    Article  PubMed  Google Scholar 

  15. Moschos MM, Panayotidis D, Theodossiadis G, Moschos M (2004) Assessment of macular function by multifocal electroretinogram in age-related macular degeneration before and after photodynamic therapy. J Fr Ophtalmol 27:1001–1006

    Article  CAS  PubMed  Google Scholar 

  16. Lai TY, Chan WM, Lam DS (2004) Transient reduction in retinal function revealed by multifocal electroretinogram after photodynamic therapy. Am J Ophthalmol 137:826–833

    Article  PubMed  Google Scholar 

  17. Arias L, Caminal JM, Casas L, Masuet C, Badia MB, Rubio M, Pujol O, Arruga J (2008) A study comparing two protocols of treatment with intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Br J Ophthalmol 92:1636–1641

    Article  CAS  PubMed  Google Scholar 

  18. Roh MI, Kim HS, Song JH, Lim JB, Kwon OW (2009) Effect of intravitreal bevacizumab injection on aqueous humor cytokine levels in clinically significant macular edema. Ophthalmology 116:80–86

    Article  PubMed  Google Scholar 

  19. Moschos MM, Moschos M (2008) Intraocular bevacizumab for macular edema due to CRVO. A multifocal-ERG and OCT study. Doc Ophthalmol 116:147–152

    Article  PubMed  Google Scholar 

  20. Imai H, Honda S, Nakanishi Y, Yamamoto H, Tsukahara Y, Negi A (2006) Different transitions of multifocal electroretinogram recordings between patients with age-related macular degeneration and polypoidal choroidal vasculopathy after photodynamic therapy. Br J Ophthalmol 90:1524–1530

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This study was supported by the National Basic Research Program of China (grant no. 2007CB512206).

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Authors and Affiliations

  1. Department of Ophthalmology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China

    Yan Liu

  2. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, 510060, China

    Feng Wen, Jiaqing Li, Chengguo Zuo & Meng Li

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  1. Yan Liu
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  2. Feng Wen
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  3. Jiaqing Li
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  4. Chengguo Zuo
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  5. Meng Li
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Corresponding author

Correspondence to Feng Wen.

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The study conformed to the provisions of the Declaration of Helsinki and informed consent was obtained from all patients.

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Liu, Y., Wen, F., Li, J. et al. Transitions of multifocal electroretinography in patients with age-related macular degeneration after combination therapy with photodynamic therapy and intravitreal bevacizumab. Doc Ophthalmol 119, 163–169 (2009). https://doi.org/10.1007/s10633-009-9189-2

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  • DOI: https://doi.org/10.1007/s10633-009-9189-2

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