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Fundus autofluorescence in cone dystrophy

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Abstract

Purpose To describe fundus autofluorescence (FAF) finding in a case of cone dystrophy. Methods Interventional case report. Results A 23-year-old woman presented with increasing photophobia and decreasing vision in both eyes for 2 years. Fundus examination showed several drusen-like dots. FAF revealed hyper-autofluorescence in the foveola. Electroretinogram (ERG) demonstrated a pure “cone” dystrophy. Conclusion Hyper-autofluorescence in the foveola is a non-specific manifestation of photoreceptor-retinal pigment epithelium dysfunction. ERG studies are essential for accurate diagnosis.

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Acknowledgments

Burroughs-Wellcome Program in Biomedical Sciences Fellow, Charles Culpeper Scholarship, Foundation Fighting Blindness, Hirschl Trust, Schneeweiss Stem Cell Fund, Joel Hoffmann Foundation, Jonas Family Fund, Crowley Research Fund, Jahnigen/Hartford/American Geriatrics Society, Eye Surgery Fund, Bernard Becker-Association of University Professors in Ophthalmology-Research to Prevent Blindness (RPB), and EY018213.

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Authors and Affiliations

  1. Bernard and Shirlee Brown Glaucoma Laboratory, Edward S. Harkness Eye Institute, 160 Fort Washington Ave, Research Annex, Room 513, New York, NY, 10032, USA

    Nan-Kai Wang, Chai Lin Chou, Wener Cella, Joaquin Tosi & Stephen H. Tsang

  2. Department of Pathology and Cell Biology, Columbia University, New York, NY, USA

    Nan-Kai Wang, Chai Lin Chou, Wener Cella, Joaquin Tosi & Stephen H. Tsang

  3. Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan

    Nan-Kai Wang

  4. Vitreous, Retina, Macula Consultants of New York, New York, NY, USA

    Luiz H. Lima & Lawrence A. Yannuzzi

  5. The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, NY, USA

    Lawrence A. Yannuzzi

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  1. Nan-Kai Wang
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  2. Chai Lin Chou
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  3. Luiz H. Lima
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  4. Wener Cella
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  5. Joaquin Tosi
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  6. Lawrence A. Yannuzzi
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  7. Stephen H. Tsang
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Corresponding author

Correspondence to Stephen H. Tsang.

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Wang, NK., Chou, C.L., Lima, L.H. et al. Fundus autofluorescence in cone dystrophy. Doc Ophthalmol 119, 141–144 (2009). https://doi.org/10.1007/s10633-009-9172-y

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  • DOI: https://doi.org/10.1007/s10633-009-9172-y

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