Abstract
Purpose:
To evaluate the changes in electrooculography (EOG) after photodynamic therapy (PDT).
Methods:
Thirty-eight eyes of 38 patients (21 males, 17 females) with choroidal neovascularization secondary to age related macular degeneration were included in this study. Standart PDT with verteporfin was performed on each patient. Serial EOG recordings were performed before, 1 week, and 1 month after PDT.
Results:
Mean age of the patients was 69.8±9.7 years (range 56 and 90 years). Seven days after PDT the visual acuity improved in 17 eyes, remained unchanged in 16 eyes and deteriorated in 5 eyes. One month after PDT the visual acuity findings were the same as the first week. New hemorrhages were seen in three eyes in the first week after PDT and visual acuity was decreased in those patients. No other patient complained of ocular and systemic adverse events. There was a statistically significant reduction in the Arden ratio of the EOG 1 week after PDT and the reduction persisted in the first month recordings.
Conclusions:
The reduction in Arden ratio of EOG findings may indicate that retina pigment epithelium function could be affected after PDT.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in agerelated macular degeneration with verteporfin. One-year results of 2 randomized clinical trials: TAP report 1. Arch Ophthalmol 1999; 117: 1329–45
Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in agerelated macular degeneration with verteporfin. Two-year results of 2 randomized clinical trials: TAP report 2. Arch Ophthalmol 2001; 119: 198–207
Verteporfin in Photodynamic Therapy Study Group. Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization: verteporfin in photodynamic therapy report 2. Am J Ophthalmol 2001; 131: 541–60
US Schmidt-Erfurth T Hasan (2000) ArticleTitleMechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration Surv Ophthalmol 45 195–214 Occurrence Handle1:STN:280:DC%2BD3M7gslKjsA%3D%3D Occurrence Handle11094244
DM Moshfeghi PK Kaiser HE Grossniklaus et al. (2003) ArticleTitleClinicopathologic study after submacular removal of choroidal neovascular membranes treated with verteporfin ocular photodynamic therapy Am J Ophthalmol 135 343–50 Occurrence Handle10.1016/S0002-9394(02)01936-0 Occurrence Handle1:CAS:528:DC%2BD3sXhsValsbs%3D Occurrence Handle12614752
RW Flower C Kerczek Particlevon L Zhu et al. (2001) ArticleTitleTheoretical investigation of the role of choriocapillaris blood flow in the treatment of subfoveal choroidal neovascularization associated with age-related macular degeneration Am J Ophthalmol 132 85–93 Occurrence Handle10.1016/S0002-9394(01)00872-8 Occurrence Handle1:STN:280:DC%2BD3MzosVajug%3D%3D Occurrence Handle11438059
J Wachtlin T Behme H Heimann U Kellner MH Foerster (2003) ArticleTitleConcentric retinal pigment epitheliumium atrophy after a single photodynamic therapy Graefes Arch Clin Exp Ophthalmol 241 518–21 Occurrence Handle10.1007/s00417-003-0734-5 Occurrence Handle12734707
Fishman GA. The electro-oculogram in retinal disorders. In: Fishman GE, Sokol S, eds. Electrophysiologic testing in disorders of the retina, optic nerve, and visual pathway. Ophthalmology monographs; 2. American Academy of Ophthalmology San Francisco 1975: 96
HE Kolder (1991) Electro-oculography JR Heckenlively GB Arden (Eds) Principles and practice of clinical electrophysiology and vision Mosby Year Book St Louis 301–14
MF Marmor E Zrenner (1993) ArticleTitleStandard for clinical electro-oculography Doc Ophthalmol 85 115–24 Occurrence Handle10.1007/BF01371127 Occurrence Handle1:STN:280:ByuA28vhslM%3D Occurrence Handle8082543
AH Rogers A Martidis PB Greenberg CA Puliafito (2002) ArticleTitleOptical cohorence tomography findings following photodynamic therapy of choroidal neovascularization Am J Ophthalmol 134 566–76 Occurrence Handle10.1016/S0002-9394(02)01566-0 Occurrence Handle12383814
S Michels U Schmidt-Erfurth (2003) ArticleTitleSequence of early vascular events after photodynamic therapy Invest Ophthalmol Vis Sci 44 2147–54 Occurrence Handle10.1167/iovs.02-0604 Occurrence Handle12714655
T Laı ı W Chan D Lam (2004) ArticleTitleTransient reduction in retinal function revealed by multifocal electroretinogram after photodynamic therapy Am J Ophthalmol 137 826–33
M Battaglia Parodi S Pozzo ParticleDa G Ravalico (2003) ArticleTitlePhotodynamic therapy for choroidal neovascularization associated with pattern dystrophy Retina 23 171–6 Occurrence Handle12707595
M Marmor (1998) ArticleTitleStandardization notice: EOG standard reapproved Doc Ophthalmol 95 91–2 Occurrence Handle10.1023/A:1001788731171 Occurrence Handle1:STN:280:DyaK1M3gtlSltQ%3D%3D Occurrence Handle10189184
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Oner, A., Karakucuk, S., Mirza, E. et al. Electrooculography After Photodynamic Therapy. Doc Ophthalmol 111, 83–86 (2005). https://doi.org/10.1007/s10633-005-4410-4
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10633-005-4410-4