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Etiological Changes and Prognosis of Hospitalized Patients with Acute Pancreatitis Over a 15-Year Period

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Abstract

Background

The worldwide incidence of acute pancreatitis (AP) is increasing, but the dominant etiology of AP may vary by country. Mixed etiologies are involved in the increase in the number of AP patients.

Aims

This study was to analyze the etiological changes and prognosis of AP patients and explore the prognosis of AP patients with mixed etiologies.

Methods

Using a retrospective analysis method, AP patients hospitalized from January 2007 to December 2021 were selected from a pancreatic center in Nanchang, China. Trends in the main etiologies were analyzed, and the severity and prognosis of different etiologies were compared.

Results

A total of 10,071 patients were included. Cholelithiasis (56.0%), hyperlipidemia (25.3%), and alcohol (6.5%) were the top three etiologies. The proportion of acute biliary pancreatitis (ABP) showed a decreasing trend, while the proportion of hypertriglyceridemic pancreatitis (HTGP) and alcoholic AP showed an increasing trend (all ptrend < 0.001). The incidence of organ failure and necrotizing pancreatitis was higher in patients with HTGP than in those with AP induced by other etiologies (all p < 0.05). There was no statistically significant difference in mortality among patients with different etiologies. Patients with AP due to a mixed hypertriglyceridemia-alcoholic etiology had higher ICU admission rates and were more severe than those with AP induced by other mixed etiologies.

Conclusion

In the past 15 years, the proportion of ABP has trended downward, while those of HTGP and alcoholic AP have risen. Among patients with mixed etiologies, those with a mixed hypertriglyceridemia-alcoholic etiology had a worse prognosis.

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Acknowledgments

All authors have read and approved the submitted manuscript, and the manuscript has not been submitted or published elsewhere either in whole or in part, except as an abstract.

Funding

This research was funded by the National Key Clinical Specialist Project [Award Number: (2011)872], National Natural Science Foundation of China (Grant No. 81860122), Jiangxi Province Outstanding Youth Talent Funding Program (Grant No. 20192BCBL23021), Jiangxi Province Key R&D Program Project (20202BBGL73016), and Jiangxi Clinical Research Center for Gastroenterology (Grant No. 20201ZDG02007).

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Authors and Affiliations

  1. Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People’s Republic of China

    Tianming Lai, Jiarong Li, Zhengang Zhou, Jingwen Rao, Yong Zhu, Liang Xia, Yupeng Lei, Xin Huang, Huajing Ke, Yao Wu, Pi Liu, Hao Zeng, Huifang Xiong, Lingyu Luo, Youxiang Chen, Wenhua He, Yin Zhu & Nonghua Lu

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  1. Tianming Lai
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Contributions

TL: Conception and design, analysis and interpretation of data, drafting the article and final approval of the version to be published. JL, ZZ, JR, YZ, LX, YL, XH, HK, YW, PL, HZ, HX, LL, YC: analysis and interpretation of data, revising it critically for important intellectual content and final approval of the version to be published. WH: Conception and design, analysis and interpretation of data, revising it critically for important intellectual content and final approval of the version to be published. YZ, NL: Conception and design, revising it critically for important intellectual content and final approval of the version to be published.

Corresponding author

Correspondence to Wenhua He.

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The Ethics Committee of the First Affiliated Hospital of Nanchang University approved this study (Approval Number: 2011001).

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Lai, T., Li, J., Zhou, Z. et al. Etiological Changes and Prognosis of Hospitalized Patients with Acute Pancreatitis Over a 15-Year Period. Dig Dis Sci 69, 56–65 (2024). https://doi.org/10.1007/s10620-023-08172-0

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