Skip to main content

Advertisement

Log in

Prevalence of Pulmonary Diseases in Association with Inflammatory Bowel Disease

  • Original Article
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Background

Prior reports from small studies suggested an increased prevalence of respiratory diseases in patients with inflammatory bowel disease (IBD). Large population-based contemporary studies evaluating this association are lacking.

Methods

In this retrospective observational cohort study utilizing the US Nationwide Readmissions Database year 2014, IBD patients ≥ 15 years of age were identified. Outcomes analyzed were the differences in the rates of diagnosed respiratory diseases between IBD and age- and sex-matched non-IBD control groups, and between patients with ulcerative colitis (UC) and Crohn disease (CD).

Results

The IBD study cohort and the matched non-IBD control group had 87,506 patients each (mean age, 52 years; 57% females). In patients with IBD, obstructive respiratory diseases were the most prevalent (asthma, 8.6%; and chronic obstructive pulmonary disease, 8.7%) followed by pleural diseases (1.9%). Compared with the non-IBD cohort, patients with IBD had a 46% higher rate of bronchiectasis, 52% higher rate of pulmonary vasculitis and interstitial pneumonia, 35% higher risk for lung nodules, 16% higher rate of pulmonary fibrosis, and a 5.5% higher rate of asthma. Among patients with IBD, patients with CD, compared with UC, had a 34% lower age/sex-adjusted risk for bronchiectasis, 56% lower risk for pulmonary vasculitis, 14% lower risk for pleural diseases, and approximately 30% higher risk for chronic obstructive pulmonary diseases.

Conclusion

In this large population-based cohort study, patients with IBD had higher rates of certain respiratory diseases compared with the general population without IBD, and significant differences were present between CD and UC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Casella G, Villanacci V, Di Bella C, Antonelli E, Baldini V, Bassotti G. Pulmonary diseases associated with inflammatory bowel diseases. J Crohns Colitis 2010;4:384–389. https://doi.org/10.1016/j.crohns.2010.02.005.

    Article  PubMed  Google Scholar 

  2. Black H, Mendoza M, Murin S. Thoracic manifestations of inflammatory bowel disease. Chest 2007;131:524–532. https://doi.org/10.1378/chest.06-1074.

    Article  PubMed  Google Scholar 

  3. Massart A, Hunt DP. Pulmonary manifestations of inflammatory bowel disease. Am J Med 2020;133:39–43. https://doi.org/10.1016/j.amjmed.2019.07.007.

    Article  PubMed  Google Scholar 

  4. Chiu K, Wright JL. Large and small airway disease related to inflammatory bowel disease. Arch Pathol Lab Med 2017;141:470–473. https://doi.org/10.5858/arpa.2016-0188-RS.

    Article  PubMed  Google Scholar 

  5. Bernstein CN, Wajda A, Blanchard JF. The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study. Gastroenterology 2005;129:827–836. https://doi.org/10.1053/j.gastro.2005.06.021.

    Article  PubMed  Google Scholar 

  6. Storch I, Sachar D, Katz S. Pulmonary manifestations of inflammatory bowel disease. Inflamm Bowel Dis 2003;9:12.

    Article  Google Scholar 

  7. Loftus EV. Inflammatory bowel disease extending its reach. Gastroenterology 2005;129:1117–1120. https://doi.org/10.1053/j.gastro.2005.07.042.

    Article  PubMed  Google Scholar 

  8. Songür N, Songür Y, Tüzün M et al. Pulmonary function tests and high-resolution CT in the detection of pulmonary involvement in inflammatory bowel disease. J Clin Gastroenterol 2003;37:292–298. https://doi.org/10.1097/00004836-200310000-00006.

    Article  PubMed  Google Scholar 

  9. Zhao Y, Wang J, Liu Z, Lin H, Shi Y, Sun X. Pulmonary dysfunction in 114 patients with inflammatory bowel disease. Medicine (Baltimore) 2017;96:e6808. https://doi.org/10.1097/MD.0000000000006808.

    Article  Google Scholar 

  10. Ceyhan BB, Karakurt S, Cevik H, Sungur M. Bronchial hyperreactivity and allergic status in inflammatory bowel disease. Respir Int Rev Thorac Dis 2003;70:60–66. https://doi.org/10.1159/000068407.

    Article  Google Scholar 

  11. NRD Overview. Accessed March 21, 2019. https://www.hcup-us.ahrq.gov/nrdoverview.jsp

  12. Hedin CRH, Vavricka SR, Stagg AJ et al. The pathogenesis of extraintestinal manifestations: implications for IBD research, diagnosis, and therapy. J Crohns Colitis 2019;13:541–554. https://doi.org/10.1093/ecco-jcc/jjy191.

    Article  CAS  PubMed  Google Scholar 

  13. Loftus EV. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 2004;126:1504–1517. https://doi.org/10.1053/j.gastro.2004.01.063.

    Article  PubMed  Google Scholar 

  14. Cozzi D, Moroni C, Addeo G et al. Radiological patterns of lung involvement in inflammatory bowel disease. Gastroenterol Res Pract. 2018. https://doi.org/10.1155/2018/5697846.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Mahadeva R, Walsh G, Flower CD, Shneerson JM. Clinical and radiological characteristics of lung disease in inflammatory bowel disease. Eur Respir J 2000;15:41–48.

    Article  CAS  Google Scholar 

  16. Camus P, Piard F, Ashcroft T, Gal AA, Colby TV. The lung in inflammatory bowel disease. Medicine (Baltimore) 1993;72:151–183.

    Article  CAS  Google Scholar 

  17. Spira A, Grossman R, Balter M. Large airway disease associated with inflammatory bowel disease. Chest 1998;113:1723–1726. https://doi.org/10.1378/chest.113.6.1723.

    Article  CAS  PubMed  Google Scholar 

  18. Sato H, Okada F, Matsumoto S et al. Chest high-resolution computed tomography findings in 601 patients with inflammatory bowel diseases. Acad Radiol 2018;25:407–414. https://doi.org/10.1016/j.acra.2017.10.010.

    Article  PubMed  Google Scholar 

  19. Desai D, Patil S, Udwadia Z, Maheshwari S, Abraham P, Joshi A. Pulmonary manifestations in inflammatory bowel disease: a prospective study. Indian J Gastroenterol Off J Indian Soc Gastroenterol 2011;30:225–228. https://doi.org/10.1007/s12664-011-0129-1.

    Article  Google Scholar 

  20. Weycker D, Hansen GL, Seifer FD. Prevalence and incidence of noncystic fibrosis bronchiectasis among US adults in 2013. Chron Respir Dis 2017;14:377–384. https://doi.org/10.1177/1479972317709649.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Moeser A, Pletz MW, Hagel S, Kroegel C, Stallmach A. Lung disease and ulcerative colitis–mesalazine-induced bronchiolitis obliterans with organizing pneumonia or pulmonary manifestation of inflammatory bowel disease? Z Gastroenterol 2015;53:1091–1098. https://doi.org/10.1055/s-0041-103377.

    Article  CAS  PubMed  Google Scholar 

  22. Biener AI, Decker SL, Rohde F. Prevalence and treatment of chronic obstructive pulmonary disease (COPD) in the United States. JAMA 2019;322:602–602. https://doi.org/10.1001/jama.2019.10241.

    Article  PubMed  Google Scholar 

  23. CDC. Asthma’s effect on the nation. Centers for Disease Control and Prevention. Published January 28, 2020. Accessed July 30, 2020. https://www.cdc.gov/asthma/asthmadata.htm

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gayatri Pemmasani.

Ethics declarations

Conflict of interest

None of the authors have any relevant conflicts of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Summary

Patients with inflammatory bowel disease had higher rates of clinically diagnosed bronchiectasis, pulmonary vasculitis, interstitial pneumonia, lung nodules, pulmonary fibrosis, and asthma compared to the general population without inflammatory bowel diseases. Significant differences were present between Crohn disease and ulcerative colitis.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pemmasani, G., Loftus, E.V. & Tremaine, W.J. Prevalence of Pulmonary Diseases in Association with Inflammatory Bowel Disease. Dig Dis Sci 67, 5187–5194 (2022). https://doi.org/10.1007/s10620-022-07385-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-022-07385-z

Keywords

Navigation