Abstract
Background
Prior reports from small studies suggested an increased prevalence of respiratory diseases in patients with inflammatory bowel disease (IBD). Large population-based contemporary studies evaluating this association are lacking.
Methods
In this retrospective observational cohort study utilizing the US Nationwide Readmissions Database year 2014, IBD patients ≥ 15 years of age were identified. Outcomes analyzed were the differences in the rates of diagnosed respiratory diseases between IBD and age- and sex-matched non-IBD control groups, and between patients with ulcerative colitis (UC) and Crohn disease (CD).
Results
The IBD study cohort and the matched non-IBD control group had 87,506 patients each (mean age, 52 years; 57% females). In patients with IBD, obstructive respiratory diseases were the most prevalent (asthma, 8.6%; and chronic obstructive pulmonary disease, 8.7%) followed by pleural diseases (1.9%). Compared with the non-IBD cohort, patients with IBD had a 46% higher rate of bronchiectasis, 52% higher rate of pulmonary vasculitis and interstitial pneumonia, 35% higher risk for lung nodules, 16% higher rate of pulmonary fibrosis, and a 5.5% higher rate of asthma. Among patients with IBD, patients with CD, compared with UC, had a 34% lower age/sex-adjusted risk for bronchiectasis, 56% lower risk for pulmonary vasculitis, 14% lower risk for pleural diseases, and approximately 30% higher risk for chronic obstructive pulmonary diseases.
Conclusion
In this large population-based cohort study, patients with IBD had higher rates of certain respiratory diseases compared with the general population without IBD, and significant differences were present between CD and UC.
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References
Casella G, Villanacci V, Di Bella C, Antonelli E, Baldini V, Bassotti G. Pulmonary diseases associated with inflammatory bowel diseases. J Crohns Colitis 2010;4:384–389. https://doi.org/10.1016/j.crohns.2010.02.005.
Black H, Mendoza M, Murin S. Thoracic manifestations of inflammatory bowel disease. Chest 2007;131:524–532. https://doi.org/10.1378/chest.06-1074.
Massart A, Hunt DP. Pulmonary manifestations of inflammatory bowel disease. Am J Med 2020;133:39–43. https://doi.org/10.1016/j.amjmed.2019.07.007.
Chiu K, Wright JL. Large and small airway disease related to inflammatory bowel disease. Arch Pathol Lab Med 2017;141:470–473. https://doi.org/10.5858/arpa.2016-0188-RS.
Bernstein CN, Wajda A, Blanchard JF. The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study. Gastroenterology 2005;129:827–836. https://doi.org/10.1053/j.gastro.2005.06.021.
Storch I, Sachar D, Katz S. Pulmonary manifestations of inflammatory bowel disease. Inflamm Bowel Dis 2003;9:12.
Loftus EV. Inflammatory bowel disease extending its reach. Gastroenterology 2005;129:1117–1120. https://doi.org/10.1053/j.gastro.2005.07.042.
Songür N, Songür Y, Tüzün M et al. Pulmonary function tests and high-resolution CT in the detection of pulmonary involvement in inflammatory bowel disease. J Clin Gastroenterol 2003;37:292–298. https://doi.org/10.1097/00004836-200310000-00006.
Zhao Y, Wang J, Liu Z, Lin H, Shi Y, Sun X. Pulmonary dysfunction in 114 patients with inflammatory bowel disease. Medicine (Baltimore) 2017;96:e6808. https://doi.org/10.1097/MD.0000000000006808.
Ceyhan BB, Karakurt S, Cevik H, Sungur M. Bronchial hyperreactivity and allergic status in inflammatory bowel disease. Respir Int Rev Thorac Dis 2003;70:60–66. https://doi.org/10.1159/000068407.
NRD Overview. Accessed March 21, 2019. https://www.hcup-us.ahrq.gov/nrdoverview.jsp
Hedin CRH, Vavricka SR, Stagg AJ et al. The pathogenesis of extraintestinal manifestations: implications for IBD research, diagnosis, and therapy. J Crohns Colitis 2019;13:541–554. https://doi.org/10.1093/ecco-jcc/jjy191.
Loftus EV. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 2004;126:1504–1517. https://doi.org/10.1053/j.gastro.2004.01.063.
Cozzi D, Moroni C, Addeo G et al. Radiological patterns of lung involvement in inflammatory bowel disease. Gastroenterol Res Pract. 2018. https://doi.org/10.1155/2018/5697846.
Mahadeva R, Walsh G, Flower CD, Shneerson JM. Clinical and radiological characteristics of lung disease in inflammatory bowel disease. Eur Respir J 2000;15:41–48.
Camus P, Piard F, Ashcroft T, Gal AA, Colby TV. The lung in inflammatory bowel disease. Medicine (Baltimore) 1993;72:151–183.
Spira A, Grossman R, Balter M. Large airway disease associated with inflammatory bowel disease. Chest 1998;113:1723–1726. https://doi.org/10.1378/chest.113.6.1723.
Sato H, Okada F, Matsumoto S et al. Chest high-resolution computed tomography findings in 601 patients with inflammatory bowel diseases. Acad Radiol 2018;25:407–414. https://doi.org/10.1016/j.acra.2017.10.010.
Desai D, Patil S, Udwadia Z, Maheshwari S, Abraham P, Joshi A. Pulmonary manifestations in inflammatory bowel disease: a prospective study. Indian J Gastroenterol Off J Indian Soc Gastroenterol 2011;30:225–228. https://doi.org/10.1007/s12664-011-0129-1.
Weycker D, Hansen GL, Seifer FD. Prevalence and incidence of noncystic fibrosis bronchiectasis among US adults in 2013. Chron Respir Dis 2017;14:377–384. https://doi.org/10.1177/1479972317709649.
Moeser A, Pletz MW, Hagel S, Kroegel C, Stallmach A. Lung disease and ulcerative colitis–mesalazine-induced bronchiolitis obliterans with organizing pneumonia or pulmonary manifestation of inflammatory bowel disease? Z Gastroenterol 2015;53:1091–1098. https://doi.org/10.1055/s-0041-103377.
Biener AI, Decker SL, Rohde F. Prevalence and treatment of chronic obstructive pulmonary disease (COPD) in the United States. JAMA 2019;322:602–602. https://doi.org/10.1001/jama.2019.10241.
CDC. Asthma’s effect on the nation. Centers for Disease Control and Prevention. Published January 28, 2020. Accessed July 30, 2020. https://www.cdc.gov/asthma/asthmadata.htm
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Summary
Patients with inflammatory bowel disease had higher rates of clinically diagnosed bronchiectasis, pulmonary vasculitis, interstitial pneumonia, lung nodules, pulmonary fibrosis, and asthma compared to the general population without inflammatory bowel diseases. Significant differences were present between Crohn disease and ulcerative colitis.
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Pemmasani, G., Loftus, E.V. & Tremaine, W.J. Prevalence of Pulmonary Diseases in Association with Inflammatory Bowel Disease. Dig Dis Sci 67, 5187–5194 (2022). https://doi.org/10.1007/s10620-022-07385-z
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DOI: https://doi.org/10.1007/s10620-022-07385-z