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Bad “Good” Bile Acids and Gut Microbiota Dysbiosis in Inflammatory Bowel Disease: Mice and Humans Are Not the Same

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Abstract

The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be “bad” (proinflammatory) or “good” (anti-inflammatory). Mouse models of colitis show an increase in conjugated BAs and gut dysbiosis, including DCA-related dysbiosis, with a significant decrease in bile salt hydrolase (bsh) gene-containing taxa. Human patients with inflammatory bowel disease demonstrate, primarily, a decrease in bile acid-inducible (bai) gene-containing taxa and a deficiency in secondary BAs, suggesting their anti-inflammatory role.

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Authors and Affiliations

  1. Department of Internal Diseases, Gastroenterology and Dietetics, North-Western State Medical University Named After I.I. Mechnikov, St. Petersburg, Russia

    Stanislav Sitkin

  2. Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, St. Petersburg, Russia

    Stanislav Sitkin

  3. Department of Microbiology, State Research Institute of Highly Pure Biopreparations, St. Petersburg, Russia

    Stanislav Sitkin

  4. Department of Internal Diseases, Rīga Stradiņš University, Riga, Latvia

    Juris Pokrotnieks

  5. Centre of Gastroenterology, Hepatology and Nutrition, Pauls Stradiņš Clinical University Hospital, Riga, Latvia

    Juris Pokrotnieks

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  1. Stanislav Sitkin
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  2. Juris Pokrotnieks
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All authors drafted and critically revised the manuscript and approved the final version.

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Correspondence to Stanislav Sitkin.

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Sitkin, S., Pokrotnieks, J. Bad “Good” Bile Acids and Gut Microbiota Dysbiosis in Inflammatory Bowel Disease: Mice and Humans Are Not the Same. Dig Dis Sci 66, 925–927 (2021). https://doi.org/10.1007/s10620-020-06650-3

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  • DOI: https://doi.org/10.1007/s10620-020-06650-3

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