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Superoxide Dismutase Predicts Persistent Circulation Failure and Mortality in the Early Stage of Acute Pancreatitis

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Abstract

Objectives

Oxidative stress is an important event in the pathogenesis of acute pancreatitis. Superoxide dismutase is a major antioxidant enzyme in the body. The aim of this study was to investigate the changes in superoxide dismutase activity early in the onset of acute pancreatitis and its value in predicting the risk of organ failure and mortality.

Methods

Data for 2549 patients hospitalized from 2013 to 2017 were extracted from the prospective database, and we selected 854 adult patients who were admitted within 24 h of disease onset with complete data. Serum superoxide dismutase activities on the first, second, and third days of hospital admission for patients with different severities, organ failure, and mortality were compared. The areas under the curve for the prediction of organ failure, pancreatic necrosis, and mortality were estimated using receiver operating characteristic curves.

Results

Among the 854 adult patients, superoxide dismutase activities were significantly different among patients with mild acute pancreatitis, moderately severe acute pancreatitis, and severe acute pancreatitis (P = 0.005). Superoxide dismutase activity was significantly decreased in patients with persistent renal failure (77.8 ± 37.2), persistent circulatory failure (66.2 ± 14.9), and mortality (64.3 ± 16.0). The accuracy of superoxide dismutase with regard to predicting persistent circulatory failure and mortality was high, and the areas under the receiver operating characteristic curves were 0.83 and 0.84, respectively.

Conclusions

Superoxide dismutase activity was negatively correlated with the severity and clinical outcome of AP. Superoxide dismutase activity is highly accurate at predicting persistent circulation failure and mortality in the early stage of AP.

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Funding

This study was supported by the National Natural Science Foundation of China (81660114) and National Natural Science Foundation of China (81860122).

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Authors and Affiliations

  1. Medical College of Nanchang University, Nanchang, People’s Republic of China

    Xi Zheng, Lei Li, Yue Zhang & Bingjun Yu

  2. Department of Gastroenterology, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, Nanchang, 330006, Jiangxi, People’s Republic of China

    Xi Zheng, Lei Li, Yin Zhu, Xin Huang, Yue Zhang, Bingjun Yu, Wenhua He & Nonghua Lv

Authors
  1. Xi Zheng
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  2. Lei Li
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  3. Yin Zhu
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  4. Xin Huang
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  5. Yue Zhang
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  6. Bingjun Yu
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  7. Wenhua He
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  8. Nonghua Lv
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Contributions

W-HH and N-HL co-designed the study. XZ and LL performed all work related to the data processing, statistical analysis, and the drafting of the manuscript. YZ and B-JY participated in the data analysis and interpretation. YZ, XH, W-HH, and N-HL participated in the critical revision and modification of the manuscript. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Wenhua He.

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All authors have read and approved the submitted manuscript, and the manuscript has not been submitted or published elsewhere either in whole or in part, except as an abstract. There are no ethical/legal conflicts associated with this article.

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Zheng, X., Li, L., Zhu, Y. et al. Superoxide Dismutase Predicts Persistent Circulation Failure and Mortality in the Early Stage of Acute Pancreatitis. Dig Dis Sci 65, 3551–3557 (2020). https://doi.org/10.1007/s10620-020-06069-w

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  • DOI: https://doi.org/10.1007/s10620-020-06069-w

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